benzophenone-4-yl propionate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzophenone-4-yl propionate
• 英文别名: 4-propionyloxybenzophenone；Propionic acid 4-benzoyl-phenyl ester；(4-benzoylphenyl) propanoate
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: NHYDENVTRBMQIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzophenone-4-yl propionate 在 sodium tetrahydroborate 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以80%的产率得到benzhydrol-4-yl propionate
  参考文献：
  名称：

  Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28

  摘要：

  The recent discovery that an ERK signaling modulator [ACA-28 (2a)] preferentially kills human melanoma cell lines by inducing ERK-dependent apoptosis has generated significant interest in the field of anti-cancer therapy. In the first SAR study on 2a, here, we successfully developed candidates (2b, 2c) both of which induce more potent and selective apoptosis towards ERK-active melanoma cells than 2a, thus revealing the structural basis for inducing the ERK-dependent apoptosis and proposing the therapeutic prospect of these candidates against ERK-dependent cancers represented by melanoma.

  DOI：

  10.1016/j.bioorg.2020.104137
• 作为产物：
  描述：

  4-羟基-二苯甲酮 生成 benzophenone-4-yl propionate
  参考文献：
  名称：

  MIYANO, MASATERU;DEASON, JAMES R.

  摘要：

  DOI：

文献信息

• (Phenylethenyl) phenylpropionic acid and its ester, and method for producing (benzoylphenyl) propionic acid or its ester
  申请人：NIPPON PETROCHEMICALS COMPANY, LIMITED

  公开号：EP0282065A2

  公开（公告）日：1988-09-14

  New compounds, i.e.α-(3-(1-phenylethenyl)phenyl)­propionic acid and its esters and a method for producing α-(3-benzoylphenyl)propionic acid which is prepared by oxidizing the former compound as an intermediate. The method is characterized by the easiness in operation, the low cost and the high purity of the product.

  新化合物，即α-(3-(1-苯基乙烯基)苯基)丙酸及其酯类，以及生产α-(3-苯甲酰基苯基)丙酸的方法。 该方法的特点是操作简便、成本低、产品纯度高。
• (Phenylethenyl) phenylpropionaldehyde and method for producing (benzoylphenyl) propionic acid using the same
  申请人：NIPPON PETROCHEMICALS COMPANY, LIMITED

  公开号：EP0282066A2

  公开（公告）日：1988-09-14

  A novel compound of α-(3-(1-phenylethenyl)phenyl)­propionaldehyde and a method for producing α-(3-benzoyl­phenyl)propionic acid which is prepared by oxidizing the former compound as an intermediate. The method is characterized in the easiness in operation, the low cost and the high purity of the product.

  一种新型α-(3-(1-苯基乙烯基)苯基)丙醛化合物和一种生产α-(3-苯甲酰基苯基)丙酸的方法，该方法是以前者化合物为中间体，通过氧化制备α-(3-苯甲酰基苯基)丙酸。 该方法的特点是操作简便、成本低、产品纯度高。
• (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase
  作者：Masateru Miyano、James R. Deason、Akira Nakao、Michael A. Stealey、Clara I. Villamil、Daniel D. Sohn、Richard A. Mueller

  DOI：10.1021/jm00400a030

  日期：1988.5

  A series of 4-(acyloxy)- and 4,4'-bis(acyloxy)benzophenones were synthesized. Some of them, pivalates (trimethylacetates) and isobutyrates in particular, were found to be potent and selective inhibitors of human neutrophil (leukocyte) elastase. A series of 2-[(acyloxy)methyl]-5-(acyloxy)-4-pyrones were synthesized regioselectively from kojic acid. The 4-pyrones bearing a long chain acyl group at the 2-position and either pivaloyloxy or isobutyryloxy at the 5-position were potent and selective inhibitors of the human elastase. A number of analogues and derivatives in both series were synthesized in order to study the structure-activity relationship as summarized in Tables I-VI and in Tables IX and X. The inhibition was selective to human neutrophil elastase. No inhibition of porcine pancreatic elastase or bovine pancreatic chymotrypsin (Tables VII and XI) was observed. The most likely mechanism of inhibition is discussed. The implication of these findings for the treatment of rheumatoid arthritis and emphysema is outlined.
• MIYANO, MASATERU;DEASON, JAMES R.;NAKAO, AKIRA;STEALEY, MICHAEL A.;VILLAM+, J. MED. CHEM., 31,(1988) N 5, 1052-1061
  作者：MIYANO, MASATERU、DEASON, JAMES R.、NAKAO, AKIRA、STEALEY, MICHAEL A.、VILLAM+

  DOI：——

  日期：——
• US4683241A
  申请人：——

  公开号：US4683241A

  公开（公告）日：1987-07-28