4-(methyleneamino)phenyl(dimethyl)amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(methyleneamino)phenyl(dimethyl)amine
• 英文别名: 4-(methyleneamino)phenyldimethylamine；N,N-dimethyl-4-(methylideneamino)aniline
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: LXXLGKIWIXMQLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(methyleneamino)phenyl(dimethyl)amine 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 3.0h， 生成 N,N,N'-三甲基苯-1,4-二胺
  参考文献：
  名称：

  Direct condensation of functionalized sp³ carbons with formanilides for enamine synthesis using an in situ generated HMDS amide catalyst

  摘要：

  使用在场生成的HMDS酰胺碱通过氨基硅烷和氟化盐的组合合成了包括β-烯胺酯在内的官能化恩酰胺。

  DOI：

  10.1039/c4cc02228a
• 作为产物：
  描述：

  4-硝基苯胺 在 Pd(1,10-phenanthroline)2(OTf)2 1,10-菲罗啉 作用下， 135.0~155.0 ℃ 、6.0 MPa 条件下， 反应 5.0h， 生成 4-(methyleneamino)phenyl(dimethyl)amine
  参考文献：
  名称：

  Wchman, Petra; Borst, Leo; Kamer, Paul C. J., Chemische Berichte, 1997, vol. 130, # 1, p. 13 - 21

  摘要：

  DOI：

文献信息

• Photocatalytic reaction of arylamines/alcohols on TiO2 nano-particles
  作者：Azarmidokht Hosseinnia、Mohammad Pazouki、Ketauon Karimian

  DOI：10.1007/s11164-010-0147-0

  日期：2010.6

  In this article, the photocatalytic reaction of aniline and 4-amino N,N-dimethyl aniline with methanol, ethanol and isopropanol on anatase TiO2 nano-particles under UV (365-nm wavelength) irradiation was examined. The concentration of unreacted arylamines and products was measured by gas chromatography picks integration, and then the products were identified by mass spectroscopy analysis. By making a comparison within the rates of photocatalysis of each arylamine in different alcohols under various irradiation times, it was revealed that, in all cases, the sequence of photocatalysis rate was methanol > ethanol > isopropanol. In reactions where the concentrations of arylamine were lower than 10 mmol/l, imines were the main products and the alkylation of amines was not observed. In the higher concentration of arylamines, oxidation and dimerization was occurred.

  在这篇文章中，考察了在紫外光（365纳米波长）照射下，苯胺和4-氨基N,N-二甲基苯胺与甲醇、乙醇和异丙醇在锐钛矿TiO2纳米颗粒上的光催化反应。通过气相色谱法积分测定未反应的芳胺和产物的浓度，然后通过质谱分析鉴定产物。通过比较不同醇中各芳胺的光催化速率在不同照射时间下的变化，结果显示，在所有情况下，光催化速率的顺序为甲醇 > 乙醇 > 异丙醇。在芳胺浓度低于10 mmol/l的反应中，亚胺是主要产物，未观察到胺的烷基化。在芳胺浓度较高时，则发生了氧化和二聚反应。
• New approaches to photocatalytic reaction of low concentrations of arylamines in alcohols
  作者：Azarmidokht Hosseinnia、Mansoor Keyanpour-Rad

  DOI：10.1007/s11164-011-0472-y

  日期：2012.9

  Photocatalytic interactions of a series of arylamines, for example 1,4-phenylenediamine, 1,2-phenylenediamine, 4-aminophenol, and 2-aminophenol, at low concentrations in typical primary alcohols have been investigated in the presence of anatase TiO2 nanopowder. GC–MS analysis of the irradiated solutions showed that, except for 1,2-phenylenediamine, 10 mmol/l alcoholic solutions of the arylamines gave predominately the corresponding imines. Irradiation of 2-aminophenol under these conditions, led to oxidation and dimerization to 2-amino-3H-phenoxazin-3-one.

  在存在锐钛矿型TiO2纳米粉末的情况下，研究了一系列芳香胺（例如1,4-苯二胺、1,2-苯二胺、4-氨基苯酚和2-氨基苯酚）在典型的初级醇中低浓度的光催化相互作用。GC–MS分析照射后的溶液显示，除了1,2-苯二胺外，芳香胺的10 mmol/L醇溶液主要生成了相应的亚胺。在这些条件下照射2-氨基苯酚，导致其氧化和二聚为2-氨基-3H-苯并噁唑-3-酮。
• Photocatalytic reaction of aryl amines/alcohols on TiO2 nanoparticles
  作者：Azarmidokht Hosseinnia、Mohammad Pazouki、Ketauon Karimian

  DOI：10.1007/s11164-010-0206-6

  日期：2010.11

  In this article, the photocatalytic reaction of aniline and 4-amino N, N dimethyl aniline with methanol, ethanol and isopropanol on anatase TiO2 nano-particles under UV (365 nm wavelength) irradiation was examined. The concentration of unreacted aryl amines and products was measured by gas chromatography picks integration, and then the products were identified by mass spectroscopy analysis. By making a comparison within the rates of photocatalysis of each aryl amine in different alcohols under various irradiation times, it was revealed that, in all cases, the sequence of photocatalysis rate was methanol > ethanol > isopropanol. In reactions where the concentrations of aryl amine were lower than 10 mmol/L, imines were the main products and alkylation of amines was not observed. In the higher concentration of aryl amines, oxidation and dimerization occurred.

  本文研究了在紫外（365 nm 波长）照射下，苯胺和 4-氨基 N,N 二甲基苯胺与甲醇、乙醇和异丙醇在锐钛矿型 TiO2 纳米粒子上的光催化反应。采用气相色谱积分仪测定未反应的芳胺和产物的浓度，然后通过质谱分析鉴定产物。通过比较各芳胺在不同醇类中在不同照射时间下的光催化速率，发现在所有情况下，光催化速率的顺序都是甲醇>乙醇>异丙醇。在芳胺浓度低于10 mmol/L的反应中，亚胺是主要产物，没有观察到胺的烷基化。在较高浓度的芳胺中，发生氧化和二聚。
• 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases
  申请人：Fink Anne Cynthia

  公开号：US20070060582A1

  公开（公告）日：2007-03-15

  This invention relates to compounds of the formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.

  本发明涉及公式（I）中变量取代基的化合物，所述的化合物可用于治疗由异常MAP激酶信号通路引起的疾病和症状，例如癌症。
• Giumanini, Angelo G.; Verardo, Giancarlo; Zangrando, Ennio, Journal fur praktische Chemie (Leipzig 1954), 1987, vol. 329, # 6, p. 1087 - 1103
  作者：Giumanini, Angelo G.、Verardo, Giancarlo、Zangrando, Ennio、Lassiani, Lucia

  DOI：——

  日期：——