N,N-difluorobenzenesulfonamide | 29690-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-difluorobenzenesulfonamide
• CAS: 29690-28-6
• 化学式: C₆H₅F₂NO₂S
• 分子量: 193.174
• InChiKey: YVTKKUGONPBSQM-UHFFFAOYSA-N

物化性质

• 沸点：
  265.2±23.0 °C(Predicted)
• 密度：
  1.454±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-difluorobenzenesulfonamide 在 2,2'-联吡啶 、 锰 、 水 、 nickel dichloride 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 生成 1-phenyl-2-(phenylsulfonyl)ethan-1-one oxime
  参考文献：
  名称：

  Difluoroaminosulfonylation of Styrenes with N,N-Difluorobenzenesulfonamide

  摘要：

  DOI：

  10.1016/j.jfluchem.2021.109823
• 作为产物：
  描述：

  N-氟苯磺酰胺 在 sodium hydroxide 、 Selectfluor 作用下， 以 丙酮 为溶剂， 反应 4.5h， 生成 N,N-difluorobenzenesulfonamide
  参考文献：
  名称：

  Difluoroaminosulfonylation of Styrenes with N,N-Difluorobenzenesulfonamide

  摘要：

  DOI：

  10.1016/j.jfluchem.2021.109823

文献信息

• Organic compound having functional groups different in elimination reactivity at both terminals, organic thin film, organic device and method of producing the same
  申请人：Imada Hiroshi

  公开号：US20070195576A1

  公开（公告）日：2007-08-23

  Provided are a single monomolecular film uniform in film thickness and highly ordered in molecule alignment and its multilayer film, an organic compound allowing production of such films at high reproducibility, an organic device superior in electroconductive properties and a method of producing the same. An organic compound represented by Formula: Si(A 1 )(A 2 )(A 3 )-B—Si(A 4 )(A 5 )(A 6 ) (A 1 to A 6 each represent a hydrogen atom, a halogen atom, an alkoxy group or an alkyl group and satisfy the relationship in elimination reactivity of: A 1 to A 3 >A 4 to A 6 ; and B represents a bivalent organic group), an organic thin film using the compound, and an organic device having the thin film; A method of producing an organic thin film and organic device, comprising a step of forming a single monomolecular film by allowing the silyl group having A 1 to A 3 in the organic compound to react with the substrate surface; a step of removing unreacted organic compounds by using a non-aqueous solvent; and a step of forming an additional monomolecular film of the organic compound by using the unreacted silyl groups present on the film surface side of the monomolecular film obtained as the sites for adsorption reaction.

  提供了一种在薄膜厚度上均匀且分子排列高度有序的单分子膜以及其多层膜，一种有机化合物可在高可重复性下制备这种膜，一种优越于导电性能的有机器件以及其生产方法。一种由化学式表示的有机化合物：Si(A1)(A2)(A3)-B—Si(A4)(A5)(A6)（其中A1到A6分别表示氢原子、卤素原子、烷氧基或烷基，并满足消除反应性的关系：A1到A3>A4到A6；B表示二价有机基），使用该化合物的有机薄膜，以及具有该薄膜的有机器件；一种制备有机薄膜和有机器件的方法，包括以下步骤：通过使具有A1到A3的硅基团与基底表面反应形成单分子膜；使用非水溶剂去除未反应的有机化合物；通过利用单分子膜表面上存在的未反应硅基团作为吸附反应位点形成有机化合物的额外单分子膜。
• Base-promoted radical decarboxylative coupling of N,N-Difluorobenzenesulfonamide and cinnamic acid
  作者：Fan Fei、Xianjin Yang

  DOI：10.1016/j.tet.2022.133169

  日期：2023.1

  A base-promoted decarboxylative sulfonylation of cinnamic acids with N,N-difluorobenzenesulfonamide (DFBSAs) is developed. This study offers a highly efficient metal and oxidant-free strategy for the preparation of (E)-vinyl sulfones. Moreover, the transformation is proposed to proceed via a radical process and exhibits broad substrate scopes and good functional group tolerance.

  开发了一种碱促进的肉桂酸与 N,N-二氟苯磺酰胺 (DFBSA) 的脱羧磺酰化反应。本研究为 ( E )-乙烯基砜的制备提供了一种高效的无金属和无氧化剂策略。此外，建议通过激进的过程进行转化，并表现出广泛的底物范围和良好的官能团耐受性。
• Methods for treatment of melanoma
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US10016402B2

  公开（公告）日：2018-07-10

  Embodiments of the present invention are directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods comprise screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma.

  本发明的实施方案涉及使用二氢烟酸脱氢酶(DHODH)抑制剂治疗黑色素瘤的方法，以及涉及向受试者施用致癌BRAF(例如BRAF(V600E))抑制剂以及二氢烟酸脱氢酶(DHODH)抑制剂的联合疗法。还提供了用于鉴定治疗黑色素瘤的化合物的检测方法。这些方法包括在黑色素瘤斑马鱼模型中筛选抑制神经嵴祖细胞形成的化合物或制剂。
• Use of BRaf inhibitors for treating cutaneous reactions
  申请人：Lutris Pharma Ltd.

  公开号：US10632123B2

  公开（公告）日：2020-04-28

  The invention discloses compositions comprising BRaf inhibitors and uses thereof for treating and/or preventing by topical or systemic administration cutaneous conditions caused by treatment with EGFR inhibitors and/or PI3K inhibitors.

  本发明公开了包含 BRaf 抑制剂的组合物及其用途，可通过局部或全身给药治疗和/或预防表皮生长因子受体抑制剂和/或 PI3K 抑制剂治疗引起的皮肤病。
• Methods of screening BRaf inhibitors for treating cutaneous reactions
  申请人：Lutris Pharma Ltd.

  公开号：US11197861B2

  公开（公告）日：2021-12-14

  The invention discloses methods for screening out of a BRaf inhibitor population, suitable BRaf inhibitors as candidates for clinical development of drugs for treating and/or preventing cutaneous reaction caused by treatment with EGFR inhibitor and/or PI3K inhibitors.

  本发明公开了从BRaf抑制剂群体中筛选出合适的BRaf抑制剂作为临床开发候选药物的方法，这些候选药物可用于治疗和/或预防表皮生长因子受体抑制剂和/或PI3K抑制剂治疗引起的皮肤反应。