1-(but-2-enyloxy)-2,4-dimethoxybenzene | 181356-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(but-2-enyloxy)-2,4-dimethoxybenzene
• 英文别名: 1-But-2-enoxy-2,4-dimethoxybenzene；1-but-2-enoxy-2,4-dimethoxybenzene
• CAS: 181356-74-1
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: CULAQAYUCIOWRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(but-2-enyloxy)-2,4-dimethoxybenzene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) copper diacetate 、 氧气 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 23.0h， 生成 6,8-dimethoxy-4-methyl-4H-chromene
  参考文献：
  名称：

  Ring-closing metathesis for the synthesis of 2H- and 4H-chromenes

  摘要：

  Six 4H-chromenes were synthesized from substituted phenols using vinylstannylation and ring-closing metathesis (RCM) as key steps. In addition, a different approach involving amongst other steps, an aryl allyl isomerization and RCM afforded a set of seven 2H-chromenes from phenolic precursors. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.020
• 作为产物：
  描述：

  1-溴-2-丁烯 、 2,4-二甲氧基苯酚 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 1-(but-2-enyloxy)-2,4-dimethoxybenzene
  参考文献：
  名称：

  Ring-closing metathesis for the synthesis of 2H- and 4H-chromenes

  摘要：

  Six 4H-chromenes were synthesized from substituted phenols using vinylstannylation and ring-closing metathesis (RCM) as key steps. In addition, a different approach involving amongst other steps, an aryl allyl isomerization and RCM afforded a set of seven 2H-chromenes from phenolic precursors. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.020

文献信息

• Ring-closing metathesis for the synthesis of 2H- and 4H-chromenes
  作者：Willem A.L. van Otterlo、E. Lindani Ngidi、Samuel Kuzvidza、Garreth L. Morgans、Simon S. Moleele、Charles B. de Koning

  DOI：10.1016/j.tet.2005.08.020

  日期：2005.10

  Six 4H-chromenes were synthesized from substituted phenols using vinylstannylation and ring-closing metathesis (RCM) as key steps. In addition, a different approach involving amongst other steps, an aryl allyl isomerization and RCM afforded a set of seven 2H-chromenes from phenolic precursors. (c) 2005 Elsevier Ltd. All rights reserved.