2-(bromomethyl)-1,3-dioxepane | 57626-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧环庚烷
• 英文名称: 2-(bromomethyl)-1,3-dioxepane
• CAS: 57626-95-6
• 化学式: C₆H₁₁BrO₂
• mdl: MFCD00457563
• 分子量: 195.056
• InChiKey: ROMIFTSWMNAXQS-UHFFFAOYSA-N

物化性质

• 沸点：
  225.9±25.0 °C(Predicted)
• 密度：
  1.388±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(bromomethyl)-1,3-dioxepane 在 potassium tert-butylate 、 水 、 溶剂黄146 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 4.0h， 生成 4-acetoxy-1-butanol
  参考文献：
  名称：

  Preparation of monoacetylated diols via cyclic ketene acetals

  摘要：

  DOI：

  10.1021/jo00122a075
• 作为产物：
  描述：

  二氧杂环庚烷 在 di-tert-butyldicyclohexano-18-crown-18 溴 作用下， 以 苯 为溶剂， 反应 0.17h， 以95%的产率得到2-(bromomethyl)-1,3-dioxepane
  参考文献：
  名称：

  Kotlyar; Pluzhnik-Gladyr', Russian Journal of General Chemistry, 1998, vol. 68, # 6, p. 914 - 916

  摘要：

  DOI：

文献信息

• IMPLANTABLE SWELLABLE BIO-RESORBABLE POLYMER
  申请人：Moine Laurence

  公开号：US20130344159A1

  公开（公告）日：2013-12-26

  The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH 2 ═CR 1 )CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR 2 R 3 )m-CH 3 , (CH 2 —CH 2 —O)m-H, (CH 2 —CH 2 —O)m-CH 3 , (CH 2 )m-NR 4 R 5 with m representing an integer from 1 to 30; R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

  本发明涉及一种聚合物，其由以下单体的聚合而得：(i)至少一种化学式(I) (CH2═CR1)CO—K (1)的单体，其中：K代表O—Z或NH—Z，Z代表(CR2R3)m-CH3，( — —O)m-H，( — —O)m- ，( )m-NR4R5，其中m代表1到30之间的整数；R1、R2、R3、R4和R5独立地代表H或C1-C6烷基；(ii)至少在0.1到50%摩尔之间，优选在1到30%摩尔之间，更优选在1到20摩尔%之间的含有化学式(II)的环状单体的聚合物，其中：R6、R7、R8和R9独立地代表H或C5-C7芳基，或R6和R9不存在且R7和R8与它们键合的碳原子一起形成C5-C7芳基；i和j独立地代表0到2之间的整数；X代表O或X不存在，在后一种情况下，CR6R7和CR8R9通过单键C—C连接；(iii)至少一种生物可吸收的嵌段共聚物交联剂。
• Preparation of Racemic and Enantiomerically Pure Cyclic Ketene Acetals
  作者：A. Díaz-Ortiz、E. Díez-Barra、A. de la Hoz、P. Prieto

  DOI：10.1080/00397919308009850

  日期：1993.7

  Abstract Cyclic ketene acetals have been prepared from a-haloaldehyde dimethylacetals by transacetalization and subsequent elimination in PTC without solvent conditions. No racemization has been observed when an enantiomerically pure diol has been used. Stability and storage conditions have been studied.

  摘要 环烯酮缩醛已由α-卤代醛二甲基缩醛通过乙缩醛转移和随后在无溶剂条件下的PTC中消除来制备。当使用对映体纯二醇时，没有观察到外消旋化。已经研究了稳定性和储存条件。
• A short and efficient synthesis of ketene O,O- and S,S-acetals under focused microwave irradiation and solvent-free conditions
  作者：Angel Díaz-Ortiz、Pilar Prieto、André Loupy、David Abenhaïm

  DOI：10.1016/0040-4039(96)00110-4

  日期：1996.3

  A new methodology leading to ketene O,O- and S,S-acetals is reported. The title compounds were prepared from the corresponding halogenated precursors under microwave irradiation in the absence of solvent within 5–25 minutes with excellent yields. Yields obtained under microwaves are by far the best when compared to those obtained by ultrasound or classical heating in the same conditions of time and

  报道了导致烯酮O，O-和S，S-乙缩醛的新方法。标题化合物是由相应的卤代前体在无溶剂下于5-25分钟内在微波辐射下制备的，具有优异的收率。与在相同的时间和温度条件下通过超声或经典加热获得的产率相比，在微波下获得的产率迄今为止是最好的。
• Character of the products of bromination of 1,3-dioxacyclanes with N-bromosuccinimide
  作者：S. A. Kotlyar、G. L. Kamalov

  DOI：10.1007/bf00507238

  日期：1981.2
• Kotlyar; Pluzhnik-Gladyr'; Zlotskii, Russian Journal of General Chemistry, 1998, vol. 68, # 2, p. 283 - 284
  作者：Kotlyar、Pluzhnik-Gladyr'、Zlotskii

  DOI：——

  日期：——