1-(4-chlorophenoxy)-3-(4-chlorophenylamino)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4-chlorophenoxy)-3-(4-chlorophenylamino)propan-2-ol
• 英文别名: 1-(4-Chloroanilino)-3-(4-chlorophenoxy)propan-2-ol
• 化学式: C₁₅H₁₅Cl₂NO₂
• 分子量: 312.196
• InChiKey: WSKVAGSQCTWBBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯苯基缩水甘油醚 、 对氯苯胺 反应 0.17h， 以67%的产率得到1-(4-chlorophenoxy)-3-(4-chlorophenylamino)propan-2-ol
  参考文献：
  名称：

  环氧化物在无溶剂条件下的微波辅助开环

  摘要：

  摘要 芳氧基甲基环氧化物与苯胺在无溶剂条件和微波辐射下反应可得到高产率的 1-芳基氨基-3-芳氧基丙-2-醇。反应迅速且完全具有区域选择性。

  DOI：

  10.1080/00397910500522025

文献信息

• Microwave‐Assisted Ring Opening of Epoxides in Solvent‐Free Conditions
  作者：Wei Tan、Bao‐Xiang Zhao、Lei Sha、Pei‐Fu Jiao、Mao‐Sheng Wan、Lei Su、Dong‐Soo Shin

  DOI：10.1080/00397910500522025

  日期：2006.6.1

  Abstract The reaction of aryloxymethyl epoxide with anilines under solvent‐free conditions and microwave irradiation affords high yields of 1‐arylamino‐3‐aryloxypropan‐2‐ols. The reaction was rapid and completely regioselective.

  摘要 芳氧基甲基环氧化物与苯胺在无溶剂条件和微波辐射下反应可得到高产率的 1-芳基氨基-3-芳氧基丙-2-醇。反应迅速且完全具有区域选择性。
• Fe(OH)3 nano solid material: An efficient catalyst for regioselective ring opening of aryloxy epoxide with amines under solvent free condition
  作者：Arpan K. Shah、K. Jeya Prathap、Manish Kumar、Sayed H.R. Abdi、Rukhsana I. Kureshy、Noor-ul H. Khan、Hari C. Bajaj

  DOI：10.1016/j.apcata.2013.10.003

  日期：2014.1

  Iron hydroxide-Fe(OH)(3) and iron oxides (Fe3O4 and Fe2O3) were successfully prepared and characterized. These materials were employed as efficient and environmentally benign heterogeneous catalysts for the epoxide ring opening reaction of various alyloxy, terminal and meso epoxides with aromatic and aliphatic amines under solvent free condition at room temperature. Out of these, nano-sized Fe(OH)(3) (IH-1) showed better catalytic activity to give the product beta-amino alcohols in excellent yield (up to similar to 96%) and high regioselectivity in 10-360 min. The catalyst was successfully recycled and reused eight times with no loss in catalytic activity. (C) 2013 Published by Elsevier B.V.