2,3-dichlorobutanenitrile | 34362-22-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,3-dichlorobutanenitrile
• 英文别名: 2,3-dichloro-butyronitrile；2,3-Dichlor-butyronitril；α,β-Dichlor-butyronitril
• CAS: 34362-22-6
• 化学式: C₄H₅Cl₂N
• mdl: MFCD01317554
• 分子量: 137.996
• InChiKey: MTDNUACQNXDFAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  123-124 °C
• 密度：
  1.238±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-dichlorobutanenitrile 在 sodium hydroxide 作用下， 生成 (Z)-2-Chloro-but-2-enoic acid
  参考文献：
  名称：

  Streambank and vegetation response to simulated cattle grazing

  摘要：

  Simulated grazing techniques were used to investigate livestock impacts on structural and vegetation characteristics of streambanks in central Idaho, USA. The treatments, continued over two years, consisted of no grazing, simulated moderate early summer grazing, simulated moderate mid-summer grazing, and simulated heavy season-long grazing. The moderate treatments depressed the streambank surface about 3 cm, while the heavy season-long treatment resulted in an 11.5-cm depression. There were no differences between the no-grazing and moderate-grazing treatments for change in stream width, bank angle, bank retreat, or root biomass. The heavy season-long treatment, however, produced significant changes in these variables. The amount of foliage biomass (i.e., kg ha(-1)) removed by treatment was similar between the two years of study for the moderate treatments. The foliage removed from the heavy season-long treatment plots greatly decreased in the second year as plant growth decreased. Ten months after the last treatment application, the average spring foliage growth was 20-43% lower on the moderate treatment plots and 51-87% lower on the heavy season-long treatment plots than on the untreated control plots.

  DOI：

  10.1672/0277-5212(2002)022[0139:savrts]2.0.co;2
• 作为产物：
  描述：

  2-羟基-3-丁烯腈 在 氯化亚砜 作用下， 生成 2,3-dichlorobutanenitrile
  参考文献：
  名称：

  Streambank and vegetation response to simulated cattle grazing

  摘要：

  Simulated grazing techniques were used to investigate livestock impacts on structural and vegetation characteristics of streambanks in central Idaho, USA. The treatments, continued over two years, consisted of no grazing, simulated moderate early summer grazing, simulated moderate mid-summer grazing, and simulated heavy season-long grazing. The moderate treatments depressed the streambank surface about 3 cm, while the heavy season-long treatment resulted in an 11.5-cm depression. There were no differences between the no-grazing and moderate-grazing treatments for change in stream width, bank angle, bank retreat, or root biomass. The heavy season-long treatment, however, produced significant changes in these variables. The amount of foliage biomass (i.e., kg ha(-1)) removed by treatment was similar between the two years of study for the moderate treatments. The foliage removed from the heavy season-long treatment plots greatly decreased in the second year as plant growth decreased. Ten months after the last treatment application, the average spring foliage growth was 20-43% lower on the moderate treatment plots and 51-87% lower on the heavy season-long treatment plots than on the untreated control plots.

  DOI：

  10.1672/0277-5212(2002)022[0139:savrts]2.0.co;2

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDINE COMPOUNDS AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS PYRIDINE SUBSTITUÉS ET DE LEURS INTERMÉDIAIRES
  申请人：PI INDUSTRIES LTD

  公开号：WO2022053994A1

  公开（公告）日：2022-03-17

  The present invention discloses a process for the preparation of substituted pyridine compounds of formula (I), comprises a step in which vinylogous nitriles of formula (II), are obtained from substituted α,β-unsaturated nitrile compounds of formula (III), and a further step of converting the vinylogous nitrile compounds of formula (II) into substituted pyridines of formula (I); wherein R1, R2, R3, R4 and LG are as defined in the description.

  本发明揭示了一种制备式(I)的取代吡啶化合物的方法，包括以下步骤：从式(III)的取代α，β-不饱和腈化合物中获得式(II)的藤黄烷腈，以及将式(II)的藤黄烷腈化合物转化为式(I)的取代吡啶的进一步步骤；其中R1，R2，R3，R4和LG如描述中所定义。
• A method for the preparation of an optically active 2-substituted carboxylic acid
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0356912A2

  公开（公告）日：1990-03-07

  An efficient microbiological or biochemical method is proposed for the preparation of an optically active 2- substituted carboxylic acid, e.g., 2-chloropropionic acid, 2-methyl butyric acid and the like, from the corresponding 2-substituted nitrile compound, e.g., 2-chloropropionitrile, 2-methyl butyronitrile and the like, in the form of a racemic body as the starting material. The method comprises bringing the starting nitrile compound into contact with a microorganism, such as Pseudomonas sp. MY-1 (FERM BP-2541), Fusarium sp. MY-2 (FERM BP-2542) and the like, capable of converting the nitrile compound into the carboxylic acid in a buffered aqueous medium in which the microbial cells of the microorganism are suspended.

  本发明提出了一种高效的微生物学或生物化学方法，用于以相应的 2-取代腈化合物，如 2-氯丙腈、2-甲基丁腈等外消旋体形式的 2-取代羧酸为起始原料制备光学活性 2-取代羧酸。该方法包括使起始腈化合物与微生物接触，如假单胞菌 MY-1（FERM BP-2541）、镰刀菌 MY-2（FERM BP-2542）等，这些微生物能够在缓冲水介质中将腈化合物转化为羧酸，该介质中悬浮着微生物的微生物细胞。
• PROCESS FOR PRODUCING 5-AMINO-3-METHYLPYRAZOLE
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0559909A1

  公开（公告）日：1993-09-15

  A process for producing 5-amino-3-methylpyrazole which comprises reacting hydrazine with a reaction intermediate prepared from 2,3-dichloropropene and hydrocyanic acid and containing at least one compound selected from the group consisting of 3-chloro-3-butenonitrile and 2,3-butadienonitrile. A process for producing 5-amino-4-chloro-3-methylpyrazole which comprises chlorinating the 5-amino-3-methylpyrazole obtained above in the presence of hydrochloric acid.

  一种生产 5-氨基-3-甲基吡唑的工艺，包括使肼与由 2,3-二氯丙烯和氢氰酸制备的反应中间体反应，该反应中间体含有至少一种选自由 3-氯-3-丁烯腈和 2,3-丁二烯腈组成的组的化合物。一种生产 5-氨基-4-氯-3-甲基吡唑的工艺，包括在盐酸存在下对上述得到的 5-氨基-3-甲基吡唑进行氯化处理。
• Alteration of hydrolase genes and screening of the resulting libraries for the ability to catalyze specific reactions
  申请人：——

  公开号：US20020042055A1

  公开（公告）日：2002-04-11

  The present invention relates to halocarbon and halohydrocarbon chemistry, including methods of dehalogenating halocarbons and halohydrocarbons to provide, inter alia, alcohols, polyols, and epoxides. In general, the methods involve reaction pathways catalyzed by altered hydrolase enzymes that can provide stereoselective or stereospecific reaction products. The invention also includes methods of providing altered nucleic acids that encode altered dehalogenase or other hydrolase enzymes. Additionally, the invention includes various reaction formats and kits.

  本发明涉及卤化碳和卤代烃化学，包括卤化碳和卤代烃以提供醇、多元醇和环氧化物等的脱卤方法。一般来说，这些方法涉及由可提供立体选择性或立体特异性反应产物的改变水解酶催化的反应途径。本发明还包括提供编码改变的脱卤酶或其他水解酶的改变的核酸的方法。此外，本发明还包括各种反应形式和试剂盒。
• Hasserodt,U., Chemische Berichte, 1967, vol. 100, # 5, p. 1482 - 1490
  作者：Hasserodt,U.

  DOI：——

  日期：——