N,N'-(biphenyl-4,4'-diyl)dibenzenesulfonamide | 52945-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(biphenyl-4,4'-diyl)dibenzenesulfonamide
• 英文别名: N,N'-biphenyl-4,4'-diyl-bis-benzenesulfonamide；4,4'-Bis-benzolsulfonylamino-biphenyl；N,N'-Biphenyl-4,4'-diyl-bis-benzolsulfonamid；N.N'-Dibenzolsulfonyl-benzidin；4',4'''-Bi[benzenesulfonanilide]；N-[4-[4-(benzenesulfonamido)phenyl]phenyl]benzenesulfonamide
• CAS: 52945-06-9
• 化学式: C₂₄H₂₀N₂O₄S₂
• 分子量: 464.566
• InChiKey: HVKQDNGNXSRNRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N'-(biphenyl-4,4'-diyl)dibenzenesulfonamide 在 lead(IV) acetate 、 盐酸 、 氯仿 作用下， 生成 N,N'-(3-chloro-biphenyl-4,4'-diyl)-bis-benzenesulfonamide
  参考文献：
  名称：

  Quinone Diimides. XV. Diphenoquinonediimides

  摘要：

  DOI：

  10.1021/ja01132a025
• 作为产物：
  描述：

  苯磺酰氯 、 联苯胺 在 吡啶 作用下， 生成 N,N'-(biphenyl-4,4'-diyl)dibenzenesulfonamide
  参考文献：
  名称：

  Quinone Diimides. XV. Diphenoquinonediimides

  摘要：

  DOI：

  10.1021/ja01132a025

文献信息

• Organophosphorus compounds—XIX
  作者：M.M. Sidky、M.R. Mahran、Y.O. El-Khoshnieh

  DOI：10.1016/s0040-4020(01)97215-1

  日期：1974.1

  4′-dihydroxydiphenyl 10; 4′-alkoxy-4-biphenylyl dialkyl phosphates 5, 4,4′-biphenylylene tetraalkyl bis(phosphates), 6, and 4′-hydroxy-4-biphenylyl dialkyl phosphates 9 are also isolated in minor yields. The effect of temperature on the reaction is studied. A mechanism for the reaction is presented which accounts for the experimental results. The reaction of trimethyl and triethyl phosphites with quinoneimines

  亚磷酸三甲酯和亚乙基三乙酯与联苯醌3反应，生成4,4'-二羟基联苯10；4'-烷氧基-4-联苯基二烷基磷酸盐5，4,4'-亚联苯基四烷基双（磷酸酯），6，和4'-羟基-4-联苯基二烷基磷酸盐9在次要的产率也分离。研究了温度对反应的影响。提出了反应的机理，其解释了实验结果。亚磷酸三甲酯和亚磷酸三乙酯与醌亚胺12的反应以定量收率得到了相应的氨基磷酸酯13。
• Novel biphenyl bis -sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies
  作者：Sadaf Mutahir、Jakub Jończyk、Marek Bajda、Islam Ullah Khan、Muhammad Asim Khan、Nisar Ullah、Muhammad Ashraf、Qurat-ul-Ain、Sadaf Riaz、Sajjad Hussain、Muhammad Yar

  DOI：10.1016/j.bioorg.2015.11.002

  日期：2016.2

  A series of new biphenyl bis-sulfonamide derivatives 2a-3p were synthesized in good to excellent yield (76-98%). The inhibitory potential of the synthesized compounds on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) was investigated. Most of the screened compounds showed modest in vitro inhibition for both AChE and BChE. Compared to the reference compound eserine (IC50 0.04 +/- 0.0001 mu M for AChE) and (IC50 0.85 +/- 0.0001 mu M for BChE), the IC50 values of these compounds were ranged from 2.27 +/- 0.01 to 123.11 +/- 0.04 mu M for AChE and 7.74 +/- 0.07 to < 400 mu M for BuChE. Among the tested compounds, 3p was found to be the most potent against AChE (IC50 2.27 +/- 0.01 mu M), whereas 3g exhibited the highest inhibition for BChE (IC50 7.74 +/- 0.07 mu M). Structure-activity relationship (SAR) of these compounds was developed and elaborated with the help of molecular docking studies. (C) 2015 Elsevier Inc. All rights reserved.
• Hinsberg, Justus Liebigs Annalen der Chemie, 1893, vol. 272, p. 232
  作者：Hinsberg

  DOI：——

  日期：——
• METHOD FOR PRODUCING OPTICAL MEMBER AND OPTICAL MEMBER FORMED BY THE PRODUCTION PROCESS
  申请人：Eiha Noriko

  公开号：US20100225013A1

  公开（公告）日：2010-09-09

  A method for producing an optical member from a nanocomposite material which includes a thermoplastic resin containing inorganic fine particles is provided. The method includes: a first step of preparing in a solution the thermoplastic resin containing the inorganic fine particles; a second step of drying and solidifying the solution containing the prepared thermoplastic resin to produce the nanocomposite material having a specific surface area (surface area/volume) of 15 mm −1 or more; and a third step of heat-compressing the produced nanocomposite material to form the optical member in a desired shape.
• Quinone Diimides. XV. Diphenoquinonediimides
  作者：Roger Adams、Richard R. Holmes

  DOI：10.1021/ja01132a025

  日期：1952.6