2'-methoxy-6'-methyl-2-chloroacetanilide | 64125-10-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-methoxy-6'-methyl-2-chloroacetanilide
• 英文别名: chloro-acetic acid-(2-methoxy-6-methyl-anilide)；Chlor-essigsaeure-(2-methoxy-6-methyl-anilid)；2'-methyl-6'-methoxy-2-chloroacetanilide；2'-methoxy-6'-methyl-2-chloracetanilide；2-chloro-N-(2-methoxy-6-methylphenyl)acetamide
• CAS: 64125-10-6
• 化学式: C₁₀H₁₂ClNO₂
• 分子量: 213.664
• InChiKey: HHRZBYFCNZFYAB-UHFFFAOYSA-N

物化性质

• 熔点：
  128-129 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 沸点：
  334.0±32.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2'-methoxy-6'-methyl-2-chloroacetanilide 生成 (3-tert-butyl-2-oxo-2λ⁴-[1,2,3]oxathiazolidin-5-ylidene)-(2-methoxy-6-methyl-phenyl)-amine
  参考文献：
  名称：

  Arya,V.P. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1977, vol. 15, p. 133 - 140

  摘要：

  DOI：
• 作为产物：
  描述：

  氯乙酰氯 、 2-甲氧基-6-甲基苯胺 生成 2'-methoxy-6'-methyl-2-chloroacetanilide
  参考文献：
  名称：

  Some New 2,6-Disubstituted-ι-dialkylaminoacetanilides

  摘要：

  DOI：

  10.1021/ja01634a029

文献信息

• Process for the production of tertiary 2-haloacetamides
  申请人：Monsanto Company

  公开号：US04258196A1

  公开（公告）日：1981-03-24

  The disclosure herein relates to a novel process for producing tertiary 2-haloacetamides by reacting primary or secondary 2-haloacetamides with an agent capable of generating an anion of the primary or secondary 2-haloacetamide under base conditions and alkylating the anion of the 2-haloamide with an alkylating agent; said anion is generated, for example, by electrolysis or by metals, metal hydrides, fluorides, oxides, hydroxides, carbonates, phosphates, or alkoxides.

  本公开涉及一种通过将一次或二次2-卤代乙酰胺与能够在碱性条件下生成一次或二次2-卤代乙酰胺的负离子的试剂反应，并用烷基化试剂烷基化2-卤代酰胺的新型生产三级2-卤代乙酰胺的方法；例如，通过电解或金属、金属氢化物、氟化物、氧化物、氢氧化物、碳酸盐、磷酸盐或烷氧基生成所述负离子。
• Process for the in-solvent, in-situ generation of haloalkyl alkyl ethers
  申请人：Monsanto Company

  公开号：US04284564A1

  公开（公告）日：1981-08-18

  The present invention is directed to a process for the preparation of certain N-substituted-2-haloacetanilides via the reaction of a secondary 2-haloacetanilide with a haloalkyl ether, particularly, halomethyl ethers, which comprises forming the ether in situ by the in-solvent reaction of an alcohol, formaldehyde or other aldehyde and an acid halide to produce high purity haloalkyl ethers, while decreasing the concentration of undesirable bis by products, as for example bis(chloromethyl) ether. The ether formed in situ thereafter reacts with the secondary 2-haloacetanilide in the presence of a phase transfer catalyst and base to form the N-substituted-2-haloacetanilide.

  本发明涉及一种通过将二级2-卤代乙酰苯胺与卤代烷醚，特别是卤代甲基醚反应，制备特定N-取代-2-卤代乙酰苯胺的方法。该方法包括通过在溶剂中将醇、甲醛或其他醛和酸卤化物进行反应以产生高纯度的卤代烷醚，同时降低不良的双卤代烷醚，例如双(氯甲基)醚的浓度。随后在位生成的醚在相转移催化剂和碱的存在下与二级2-卤代乙酰苯胺发生反应，形成N-取代-2-卤代乙酰苯胺。
• Process for producing N-(halomethyl) acyl-amides
  申请人：Monsanto Company

  公开号：US04311858A1

  公开（公告）日：1982-01-19

  The disclosure herein relates to a new process for the preparation of N-(halomethyl) acylamides by reacting the corresponding N-(alkoxymethyl) acetamide with a hydrogen halide.

  本公开涉及一种通过将相应的N-(烷氧甲基)乙酰胺与氢卤酸反应制备N-(卤甲基)酰胺的新工艺。
• A process for the in-solvent, in-situ generation of N-substituted-2-haloacetanilides
  申请人：MONSANTO COMPANY

  公开号：EP0037656A1

  公开（公告）日：1981-10-14

  The present invention is directed to a process for the preparation of certain N-substituted -2-haloacetanilides via the reaction of a secondary 2-haloacetanilide with a haloalkyl ether, particularly, halomethyl ethers, which comprises forming the ether in situ by the in-solvent reaction of an alcohol, formaldehyde or other aldehyde and an acid halide to produce high purity haloalkyl ethers, while decreasing the concentration of undesirable bis by products, as for example bis(chloromethyl) ether. The ether formed in situ thereafter reacts with the secondary 2-haloacetanilide in the presence of a phase transfer catalyst and base to form the N-substituted-2-haloacetanilide.

  本发明涉及一种通过仲2-卤乙酰苯胺与卤代烷基醚，特别是卤代甲基醚反应制备某些N-取代-2-卤乙酰苯胺的工艺，该工艺包括通过醇、甲醛或其他醛与酸卤化物的溶剂内反应原位形成醚，以生成高纯度的卤代烷基醚，同时降低不良双副产物，如双（氯甲基）醚的浓度。随后，原位形成的醚在相转移催化剂和碱的作用下与仲基 2-卤代乙酰苯胺反应，形成 N-取代的 2-卤代乙酰苯胺。
• Process for producing N-(halomethyl) acylamides
  申请人：MONSANTO COMPANY

  公开号：EP0053495A1

  公开（公告）日：1982-06-09

  The disclosure herein relates to a new process for the preparation of N-(halomethyl) acylamides by reacting the corresponding N-(alkoxy-methyl) acetamide with a hydrogen halide.

  本公开涉及一种通过相应的 N-(烷氧基甲基)乙酰胺与卤化氢反应制备 N-(卤代甲基)酰酰胺的新工艺。