methyl 6-methoxy-2',4',6'-trimethylbiphenyl-3-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 6-methoxy-2',4',6'-trimethylbiphenyl-3-carboxylate
• 英文别名: Methyl 4-methoxy-3-(2,4,6-trimethylphenyl)benzoate
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: SZWWPDJODVHTRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4,6-三甲基苯硼酸 在 四(三苯基膦)钯 silver carbonate 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 6.0h， 生成 methyl 6-methoxy-2',4',6'-trimethylbiphenyl-3-carboxylate
  参考文献：
  名称：

  Suzuki Cross-Coupling Reaction of Sterically Hindered Aryl Boronates with 3-Iodo-4-methoxybenzoic Acid Methylester

  摘要：

  The cross-coupling reaction of 3-iodo-4-methoxybenzoic acid methylester with sterically hindered arylboronic esters and especially 5,5-dimethyl-2-mesityl-1,3,2-dioxaborinane, is reported. The optimisation of the process in order to obtain biaryls in good yield by using anhydrous benzene at reflux and sodium phenoxide in the presence of 0.06 equiv. of Pd(PPh3)(4) is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00928-5

文献信息

• Suzuki Cross-Coupling Reaction of Sterically Hindered Aryl Boronates with 3-Iodo-4-methoxybenzoic Acid Methylester
  作者：H. Chaumeil、S. Signorella、C. Le Drian

  DOI：10.1016/s0040-4020(00)00928-5

  日期：2000.12

  The cross-coupling reaction of 3-iodo-4-methoxybenzoic acid methylester with sterically hindered arylboronic esters and especially 5,5-dimethyl-2-mesityl-1,3,2-dioxaborinane, is reported. The optimisation of the process in order to obtain biaryls in good yield by using anhydrous benzene at reflux and sodium phenoxide in the presence of 0.06 equiv. of Pd(PPh3)(4) is described. (C) 2000 Elsevier Science Ltd. All rights reserved.