1-methyl-2-(phenylacetamido)ethylamine | 53673-50-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-2-(phenylacetamido)ethylamine
• 英文别名: 2-amino-1-phenylacetamidopropane；1-methyl-2-phenylacetamidoethylamine；N-(2-aminopropyl)phenylacetamide；N-(2-Aminopropyl)-2-phenylacetamide
• CAS: 53673-50-0；83019-83-4；83019-84-5
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: WHCBCOGNYOBFIL-UHFFFAOYSA-N

物化性质

• 沸点：
  396.5±35.0 °C(Predicted)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-2-(phenylacetamido)ethylamine 、 苯基缩水甘油醚 在 sodium hydroxide 作用下， 以 丙醇 为溶剂， 反应 18.0h， 以22%的产率得到1-phenoxy-3-(α-methyl-β-phenylacetamidoethyl)amino-2-propanol
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols

  摘要：

  The synthesis of a series of 1-phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols is described. Many of the compounds are more potent than propanolol as beta blockers, while having cardioselectivity comparable to that of practolol, when given intravenously to anesthetized cats. The structure-activity relationships shown by this series of compounds provide further evidence that the addition of substituents to the alkylamino moeity of a beta blocker can confer cardioselectivity and that amidic substituents are remarkably effective.

  DOI：

  10.1021/jm00353a004
• 作为产物：
  描述：

  苯乙酸乙酯 、 1,2-丙二胺 生成 1-methyl-2-(phenylacetamido)ethylamine
  参考文献：
  名称：

  CH605666

  摘要：

  公开号：

文献信息

• .beta.-Adrenergic blocking agents. 19. 1-Phenyl-2-[[(substituted-amido)alkyl]amino]ethanols
  作者：M. S. Large、L. H. Smith

  DOI：10.1021/jm00176a002

  日期：1980.2

  series of derivatives of 1-phenyl-2-[[(substituted amido)alkyl]amino]ethanols is described. The compounds were investigated for beta-adrenoceptor blocking properties, and many showed a surprising degree of potency and beta 1-cardioselectivity when tested in vivo in anesthetized cats. The structure-activity relationships shown by this series of compounds are discussed and related to known beta-adrenergic

  描述了1-苯基-2-[[（取代的酰胺基烷基）氨基]氨基]乙醇的一系列衍生物的合成。研究了这些化合物的β-肾上腺素受体阻断特性，当在麻醉的猫体内进行测试时，许多化合物显示出令人惊讶的效力和β1-心脏选择性。讨论了这一系列化合物显示的结构活性关系，并与已知的β-肾上腺素能阻断剂有关。
• .beta.-Adrenergic blocking agents. 24. Heterocyclic substituted 1-(aryloxy)-3-[[(amido)alkyl]amino]propan-2-ols
  作者：M. S. Large、L. H. Smith

  DOI：10.1021/jm00354a005

  日期：1982.12

  The synthesis of a series of 1-(aryloxy)-3-[[(amido)alkyl]amino] propan-2-ols where either the aryl moiety is heterocyclic or the amidic group is substituted by a heterocyclic moiety is described. Several of the compounds were more potent than propranolol when given intravenously to anesthetized rats. In contrast to previous findings with beta-blockers based on heterocyclic moieties and with either

  描述了一系列1-（芳氧基）-3-[[（（酰胺基烷基）氨基]氨基]丙-2-醇的合成，其中芳基部分为杂环或酰胺基被杂环部分取代。静脉给予麻醉大鼠时，几种化合物比普萘洛尔更有效。与先前基于杂环基团的β受体阻滞剂以及侧链具有异丙基氨基或叔丁基氨基取代基的先前发现相反，当在麻醉的猫中进一步检查时，几种化合物被证明具有心脏选择性。讨论了该系列化合物显示的详细的构效关系。
• Alkanolamine derivatives and pharmaceutical compositions and uses thereof
  申请人：Imperial Chemical Industries Limited

  公开号：US04167581A1

  公开（公告）日：1979-09-11

  1-Aryloxy-3-aminoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-(2-cyanophenoxy)-3-.beta.(4-hydroxyphenylacetamido)ethylamino-2-propanol .

  1-芳氧基-3-氨基烷基胺基-2-丙醇衍生物，其制备方法，含有它们的药物组合物以及在治疗心脏疾病中使用它们的方法。这些化合物具有β-肾上腺素受体阻滞活性，其中一些还具有心脏刺激活性。所披露的化合物代表是1-(2-氰基苯氧基)-3-β-(4-羟基苯乙酰胺基)乙基胺基-2-丙醇。
• Ethanolamine derivatives
  申请人：Imperial Chemical Industries Limited

  公开号：US04085221A1

  公开（公告）日：1978-04-18

  Novel 1-aryl-2-amidoalkylaminoethanol derivatives which contain at least one heterocyclic substituent, processes for their manufacture, pharmaceutical compositions containing them and a method of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 2-.beta.-(2-methylthiazol-4-ylacetamido)ethylamino-1-.beta.-naphthylethano l.

  含有至少一个杂环取代基的新型1-芳基-2-酰胺烷基氨基乙醇衍生物，其制备方法，含有它们的制药组合物以及在治疗心脏疾病中使用它们的方法。这些化合物具有β-肾上腺素能阻滞活性。所披露的化合物代表是2-β-(2-甲基噻唑-4-基乙酰胺基)乙基氨基-1-β-萘乙醇。
• Alkanolamine derivatives
  申请人：Imperial Chemical Industries Limited

  公开号：US04034106A1

  公开（公告）日：1977-07-05

  Novel 1-heterocyclyloxy- or 1-aryloxy-3-amido-alkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-indolyloxy)-3-.beta.-isobutyramidoethylamino-2-propanol.

  1-杂环氧基-或1-芳氧基-3-酰胺基-烷基氨基-2-丙醇衍生物的小说，其制造方法，含有它们的药物组合物以及在治疗心脏疾病中使用它们的方法。这些化合物具有β-肾上腺素受体阻滞活性。所披露的化合物代表是1-(4-吲哚氧基)-3-β-异丁酰胺基乙基氨基-2-丙醇。