N-(2-aminoethyl)-2-(2-chlorophenyl)acetamide | 58027-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-aminoethyl)-2-(2-chlorophenyl)acetamide
• CAS: 58027-16-0
• 化学式: C₁₀H₁₃ClN₂O
• 分子量: 212.679
• InChiKey: IPQULDXQMKOLKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-aminoethyl)-2-(2-chlorophenyl)acetamide 、 苯基缩水甘油醚 在 sodium hydroxide 作用下， 以 丙醇 为溶剂， 反应 18.0h， 以33%的产率得到2-(2-chlorophenyl)-N-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl]acetamide
  参考文献：
  名称：

  .beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols

  摘要：

  The synthesis of a series of 1-phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols is described. Many of the compounds are more potent than propanolol as beta blockers, while having cardioselectivity comparable to that of practolol, when given intravenously to anesthetized cats. The structure-activity relationships shown by this series of compounds provide further evidence that the addition of substituents to the alkylamino moeity of a beta blocker can confer cardioselectivity and that amidic substituents are remarkably effective.

  DOI：

  10.1021/jm00353a004
• 作为产物：
  描述：

  乙二胺 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N-(2-aminoethyl)-2-(2-chlorophenyl)acetamide
  参考文献：
  名称：

  CH605666

  摘要：

  公开号：

文献信息

• .beta.-Adrenergic blocking agents. 23. 1-(Substituted-amido)phenoxy-3-[[(substituted-amido)alkyl]amino]propan-2-ols
  作者：M. S. Large、L. H. Smith

  DOI：10.1021/jm00357a008

  日期：1983.3

  The synthesis of a series of 1-phenoxy-3-[(amidoalkyl)amino]propan-2-ols, in which the phenoxy ring is variously substituted with ortho and para amidic moieties, is described. Several of the compounds have beta-blocking potency comparable to that of propranolol and cardioselectivity similar to that of practolol, when given intravenously to anesthetized cats. In contrast to previous findings with cardioselective beta blockers, both ortho and para substitution give variable degrees of cardioselectivity. Potency, however, is favored by ortho substitution.
• CH614925
  申请人：——

  公开号：——

  公开（公告）日：——
• LARGE, M. S.;SMITH, L. H., J. MED. CHEM., 1982, 25, N 11, 1286-1292
  作者：LARGE, M. S.、SMITH, L. H.

  DOI：——

  日期：——
• LARGE, M. S.;SMITH, L. H., J. MED. CHEM., 1983, 26, N 3, 352-357
  作者：LARGE, M. S.、SMITH, L. H.

  DOI：——

  日期：——
• CH605666
  申请人：——

  公开号：——

  公开（公告）日：——