2-phenylaminomethyl-prop-2-en-1-ol | 1024043-62-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-phenylaminomethyl-prop-2-en-1-ol
• 英文别名: 2-(Anilinomethyl)prop-2-en-1-ol；2-(anilinomethyl)prop-2-en-1-ol
• CAS: 1024043-62-6
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: ZWTCJHCELOKUSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenylaminomethyl-prop-2-en-1-ol 在 palladium on activated charcoal 氢气 作用下， 反应 24.0h， 以30%的产率得到2-methyl-3-phenylamino-propan-1-ol
  参考文献：
  名称：

  Behaviour of enaminomalonates and enamidomalonates under various reductive conditions: a novel synthetic approach to N-acetyl-N-aryl β-amino acids

  摘要：

  The behaviour of enaminomalonates and their deprotection to amines under various reductive conditions is described. A new synthetic approach to N-aryl-N-acetyl-beta-amino acids using heterogeneous catalytic hydrogenation has been discovered. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.078
• 作为产物：
  描述：

  dimethyl 2-((phenylamino)methylene)malonate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以52%的产率得到2-phenylaminomethyl-prop-2-en-1-ol
  参考文献：
  名称：

  Behaviour of enaminomalonates and enamidomalonates under various reductive conditions: a novel synthetic approach to N-acetyl-N-aryl β-amino acids

  摘要：

  The behaviour of enaminomalonates and their deprotection to amines under various reductive conditions is described. A new synthetic approach to N-aryl-N-acetyl-beta-amino acids using heterogeneous catalytic hydrogenation has been discovered. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.078

文献信息

• Fe-catalyzed synthesis of substituted N-aryl oxazolidines
  作者：Siva Murru、Charles Seth Lott、Brandon McGough、Dakota M. Bernard、Radhey S. Srivastava

  DOI：10.1039/c6ob00185h

  日期：——

  synthesis of substituted N-aryl oxazolidines was developed via C–N bond formation and methylenation. The reaction of aryl hydroxylamines with allyl alcohols, in the presence of formaldehyde or its equivalents, afforded variety of oxazolidine heterocycles in very good yields. This catalytic method is most effective for para-substituted aryl hydroxylamines and 3-methyl allyl alcohols. Furthermore, acid catalyzed

  通过C–N键的形成和亚甲基化，开发了一种新型的铁催化的取代N-芳基恶唑烷的合成方法。在甲醛或其等价物的存在下，芳基羟胺与烯丙醇的反应以非常好的收率提供了各种恶唑烷杂环。该催化方法对于对位取代的芳基羟胺和3-甲基烯丙醇最有效。此外，恶唑烷的酸催化的脱甲基化允许以良好的产率获得N-芳基氨基醇。
• Behaviour of enaminomalonates and enamidomalonates under various reductive conditions: a novel synthetic approach to N-acetyl-N-aryl β-amino acids
  作者：Tomáš Solčan、Pavol Jakubec、Nadežda Prónayová、Viktor Milata

  DOI：10.1016/j.tetlet.2008.02.078

  日期：2008.4

  The behaviour of enaminomalonates and their deprotection to amines under various reductive conditions is described. A new synthetic approach to N-aryl-N-acetyl-beta-amino acids using heterogeneous catalytic hydrogenation has been discovered. (C) 2008 Elsevier Ltd. All rights reserved.