8-benzoylnaphthalene-1-carbaldehyde | 126614-37-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-benzoylnaphthalene-1-carbaldehyde
• 英文别名: 1-benzoyl-8-formylnaphthalene
• CAS: 126614-37-7
• 化学式: C₁₈H₁₂O₂
• 分子量: 260.292
• InChiKey: MEOHVULJHNHWBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-benzoylnaphthalene-1-carbaldehyde 在 臭氧 作用下， 以 甲醇 、 二氯甲烷 、 苯 为溶剂， 反应 3.0h， 生成 1-phenyl-1-methoxy-3-hydroxyperoxy-1H,3H-naphtho<1.8-cd>pyran
  参考文献：
  名称：

  Ozonolysis of acenaphthylene and 1-substituted acenaphthylenes

  摘要：

  DOI：

  10.1021/jo00299a024
• 作为产物：
  描述：

  ethyl 5-(8-benzoylnaphthalen-1-yl)-1,2,4-trioxolane-3-carboxylate 在 silica gel 作用下， 以80%的产率得到8-benzoylnaphthalene-1-carbaldehyde
  参考文献：
  名称：

  Ozonolysis of acenaphthylene and 1-substituted acenaphthylenes

  摘要：

  DOI：

  10.1021/jo00299a024

文献信息

• Syntheses, structure analyses, and reactions of 1,3,5-trioxepanes and related compounds
  作者：Kevin J. McCullough、Araki Masuyama、Keith M. Morgan、Masatomo Nojima、Yuji Okada、Syuzo Satake、Shin-ya Takeda

  DOI：10.1039/a802928h

  日期：——

  Acid-catalysed condensations of 1,5- or 1,6-dicarbonyl compounds with ethylene glycol give 1,3,5-trioxepane derivatives as a result of neighbouring participation by the adjacent carbonyl group during the acetalization process. With trimethylene glycol, the related 1,3,5-trioxocanes have also been obtained. Reaction of the 1,3,5-trioxepanes with (a) Grignard reagents gives dialkyl-substituted cyclic

  1，5-或1，6-二羰基化合物与乙二醇的酸催化缩合产生1,3,5-三氧杂环丁烷衍生物，这是由于缩醛化过程中相邻羰基的相邻参与。使用三亚甲基二醇，也已经获得了相关的1,3,5-三氧杂环丁烷。1,3,5-三氧杂环丁烷与（a）格氏试剂反应生成二烷基取代的环状醚，（b）四氯化钛-烯丙基三丁基锡生成二烯丙基取代的环状醚，（c）在三氟甲磺酸三甲基甲硅烷基酯存在下的三乙基硅烷提供了相应的环醚。
• Ozonide compounds with inhibitory activity for urokinase production and angiogenesis
  申请人：Taiho Pharmaceutical Company Ltd.

  公开号：US06365610B1

  公开（公告）日：2002-04-02

  The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor wherein A is an oxygen atom or N—R (wherein R is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom); B is an oxo group or —R4; and (1) when A is an oxygen atom, R1 is a hydrogen atom, etc., R2 is phenyl, etc., R3 is a hydrogen atom, etc., B is an oxo group or —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.; (2) when A is N—R, R1 is a hydrogen atom, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., B is —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.

  该发明提供了一种尿激酶产生抑制剂或血管生成抑制剂，其包括作为活性成分的一种由式（1）表示的臭氧化物衍生物，以及使用该抑制剂的预防或治疗方法，其中A是氧原子或N—R（其中R是苯基或苯基，其取代基为1至6个碳原子的较低烷基，1至6个碳原子的较低烷氧基或卤原子）；B是羰基或—R4；当A是氧原子时，R1是氢原子等，R2是苯基等，R3是氢原子等，B是羰基或—R4，R4是氢原子等，R5是氢原子等；当A是N—R时，R1是氢原子等，R2是氢原子等，R3是氢原子等，B是—R4，R4是氢原子等，R5是氢原子等。
• UROKINASE PRODUCTION INHIBITORS, ANGIOGENESIS INHIBITORS AND METHODS OF PREVENTION OR TREATMENT WITH BOTH
  申请人：TAIHO PHARMACEUTICAL COMPANY LIMITED

  公开号：EP1033130A1

  公开（公告）日：2000-09-06

  The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor wherein A is an oxygen atom or N-R (wherein R is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom); B is an oxo group or -R4; and (1) when A is an oxygen atom, R1 is a hydrogen atom, etc., R2 is phenyl, etc., R3 is a hydrogen atom, etc., B is an oxo group or -R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.; (2) when A is N-R, R1 is a hydrogen atom, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., B is -R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.

  本发明提供了一种尿激酶生成抑制剂或血管生成抑制剂，其活性成分包括由式(1)表示的臭氧衍生物，以及使用该抑制剂进行预防或治疗的方法 其中 A 是氧原子或 N-R(其中 R 是苯基或具有 1 至 6 个碳原子的低级烷基、具有 1 至 6 个碳原子的低级烷氧基或卤原子作为取代基的苯基)；B 是氧代基团或 -R4；以及 (1) 当 A 是氧原子时，R1 是氢原子等，R2 是苯基等、R3 是氢原子等，B 是氧代基团或-R4，R4 是氢原子等，R5 是氢原子等；(2) 当 A 是 N-R，R1 是氢原子等，R2 是氢原子等，R3 是氢原子等，B 是-R4，R4 是氢原子等，R5 是氢原子等。
• McCullough, Kevin J.; Sugimoto, Toshiya; Tanaka, Shogo, Journal of the Chemical Society. Perkin transactions I, 1994, # 6, p. 643 - 652
  作者：McCullough, Kevin J.、Sugimoto, Toshiya、Tanaka, Shogo、Kusabayashi, Shigekazu、Nojima, Masatomo

  DOI：——

  日期：——
• Sugimoto, Toshiya; Nojima, Masatomo; Kusabayashi, Shigekazu, Journal of the American Chemical Society, 1990, vol. 112, # 9, p. 3690 - 3692
  作者：Sugimoto, Toshiya、Nojima, Masatomo、Kusabayashi, Shigekazu、McCullough, Kevin J.

  DOI：——

  日期：——