α-ethyl-α-(2-methoxyphenyl)-4-hydroxy-benzylalcohol | 92814-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-ethyl-α-(2-methoxyphenyl)-4-hydroxy-benzylalcohol
• 英文别名: 2-methoxy-4'-hydroxy-α-ethyl-benzhydrol；1-(2-methoxyphenyl)-1-(4-hydroxyphenyl)-propan-1-ol；alpha-Ethyl-alpha-(2-methoxyphenyl)-4-hydroxy-benzylalcohol；4-[1-hydroxy-1-(2-methoxyphenyl)propyl]phenol
• CAS: 92814-13-6
• 化学式: C₁₆H₁₈O₃
• 分子量: 258.317
• InChiKey: MTSRNQSEYAUFGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-ethyl-α-(2-methoxyphenyl)-4-hydroxy-benzylalcohol 、 1-溴-3-苯基丙烷 在 sodium hydroxide 、 potassium iodide 、 potassium carbonate 作用下， 以 水 、 丙酮 为溶剂， 生成 1-(2-methoxyphenyl)-1-[4-(3-phenylpropoxy)-phenyl]-propan-1-ol
  参考文献：
  名称：

  1,1-diphenylpropanol derivatives, process for their preparation and

  摘要：

  本发明涉及新的1,1-二苯基丙醇衍生物，其化学式为（I） 其中，R1和R2独立地表示氢、卤素、三卤甲基、具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基，R3表示卤素、三卤甲基、具有1至5个碳原子的烷基或具有1至5个碳原子的烷氧基，R4为苯基，可以选择性地被一个或多个相同或不同的取代基所取代，所述取代基从卤素、三卤甲基、烷基、烷氧基、氰基、硝基、氨基、烷基氨基、二烷基氨基、羟基、羧基或取代羧基的群中选择；二烷基氨基甲酰基或烷氧基甲酰基，所述烷基和烷氧基中分别含有1至4个碳原子，n为1、2、3、4或5。根据本发明的另一方面，提供了制备化合物（I）的方法。新化合物诱导肝脏的多底物单加氧酶酶系统，不具有其他药理动力学效应。含有化合物（I）作为活性成分的制药组合物也在本发明的范围内。

  公开号：

  US04605785A1

文献信息

• Certain-2-methyl-6-{4-[1-phenyl-1-hydroxypropyl]-phenoxymethyl}pyridines
  申请人：Richter Gedeon Vegyeszeti Gyar Rt

  公开号：US04598080A1

  公开（公告）日：1986-07-01

  The invention relates to new pyridine derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

  该发明涉及新的吡啶衍生物，其化学式为（I）其中R.sub.1和R.sub.2独立地代表氢、卤素、三卤甲基、具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基，以及它们的酸盐和季铵盐。根据该发明的另一个方面，提供了制备这些化合物的方法。化学式（I）的化合物具有药理活性，特别是它们抑制了肝脏的微粒体单氧酶酶系统。含有它们作为活性成分的药物组合物也属于该发明的范围内。
• 1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation
  申请人：Richter Gedeon Vegyeszeti Gyar Rt

  公开号：US04618611A1

  公开（公告）日：1986-10-21

  The invention relates to new aminopropanol derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkoxy having from one to 3 carbon atoms or alkyl having from one to 3 carbon atoms, R.sub.2 is alkyl having from one to 3 carbon atoms, and R.sub.3 is cycloalkyl having from 3 to 6 carbon atoms, or R.sub.2 and R.sub.3 together with the nitrogen they are attached to form an up to 8 membered ring optionally containing oxygen or a further nitrogen as an additional hetero atom, and optionally substituted with alkyl having from one to 4 carbon atoms or benzyl, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The new compounds are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them are also within the scope of the invention.

  该发明涉及具有以下式（I）的新的氨丙醇衍生物##STR1##其中R.sub.1是卤素、三卤甲基、具有一至三个碳原子的烷氧基或具有一至三个碳原子的烷基，R.sub.2是具有一至三个碳原子的烷基，R.sub.3是具有三至六个碳原子的环烷基，或者R.sub.2和R.sub.3连同它们附着的氮原子形成一个最多有8个成员的环，该环可以含有氧或另一氮原子作为额外的杂原子，并且可以用具有一至四个碳原子的烷基或苄基取代，以及其酸盐和季铵盐。根据该发明的另一方面，提供了制备这些化合物的方法。新化合物适用于治疗急性乙醇中毒。含有这些化合物的药物组合物也属于该发明的范围。
• Piperidine derivatives and pharmaceutical compositions containing them
  申请人：Richter Gedeon Vegyeszeti Gyar Rt.

  公开号：US04551465A1

  公开（公告）日：1985-11-05

  The invention relates to new piperidine derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms; and R.sub.2 is hydrogen or alkyl having from one to 4 carbon atoms, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

  该发明涉及具有以下结构的新哌啶衍生物（I）其中R.sub.1是卤素、三卤甲基、含有1至4个碳原子的烷基或含有1至4个碳原子的烷氧基；R.sub.2是氢或含有1至4个碳原子的烷基，以及它们的酸加合物和季铵盐。根据该发明的另一个方面，提供了制备这些化合物的方法。具有结构（I）的化合物具有药理活性。特别地，它们抑制了肝脏微粒体单加氧酶酶系统。含有它们作为活性成分的药物组合物也属于该发明的范围内。
• Diethylaminoalkoxybenzhydrol derivatives, process for their preparation
  申请人：Richter Gedeon Vegyeszeti Gyar Rt.

  公开号：US04605672A1

  公开（公告）日：1986-08-12

  The invention relates to the preparation of new diethylaminoalkoxybenzhydrol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, R.sub.2 is halogen, trihalomethyl, or alkoxy having from one to 4 carbon atoms, and n is 1, 2, 3 or 4, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention, there are provided new compounds of the formula (I), and acid addition and quaternary salts thereof. The compounds can be used for the treatment of acute ethanolic intoxication and depression syndromes. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

  本发明涉及制备新的二乙氨基烷氧基苯甲醇衍生物的方法，其化学式为(I) ##STR1##其中R.sub.1为氢、卤素、三卤甲基、1至4个碳原子的烷基或1至4个碳原子的烷氧基，R.sub.2为卤素、三卤甲基或1至4个碳原子的烷氧基，n为1、2、3或4，以及其酸加成物和季铵盐。根据本发明的另一方面，提供了化学式(I)的新化合物及其酸加成物和季铵盐。这些化合物可用于治疗急性乙醇中毒和抑郁综合症。含有它们作为活性成分的药物组合物也在本发明的范围内。
• Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
  申请人：Richter Gedeon Vegyészeti Gyár R.T.

  公开号：EP0113587A1

  公开（公告）日：1984-07-18

  The invention relates to new pyridine derivatives of the formula (I) wherein R1 and R2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

  本发明涉及式（I）的新吡啶衍生物，其中 R1 和 R2 独立地代表氢、卤素、三卤甲基、具有 1 至 4 个碳原子的烷基或具有 1 至 4 个碳原子的烷氧基，以及它们的酸加成盐和季铵盐。 根据本发明的另一方面，提供了制备这些化合物的工艺。 式（I）化合物具有药理活性，特别是它们能抑制肝脏微粒体单氧化酶系统。 含有它们作为活性成分的药物组合物也属于本发明的范围。