3-(2'-hydroxy-3'-phenoxypropyl)-5,5-dimethylimidazolidine-2,4-dione | 301160-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(2'-hydroxy-3'-phenoxypropyl)-5,5-dimethylimidazolidine-2,4-dione
• 英文别名: 3-(2-hydroxy-3-phenoxypropyl)-5,5-dimethylhydantoin；3-(2-Hydroxy-3-phenoxypropyl)-5,5-dimethylimidazolidine-2,4-dione
• CAS: 301160-84-9
• 化学式: C₁₄H₁₈N₂O₄
• 分子量: 278.308
• InChiKey: ZFKVSVOSTZLPQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯酚 在 吡啶 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 16.0h， 生成 3-(2'-hydroxy-3'-phenoxypropyl)-5,5-dimethylimidazolidine-2,4-dione
  参考文献：
  名称：

  Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

  摘要：

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.099

文献信息

• Reaction of phenyl glycidyl ether with some heterocycles
  作者：E. G. Mesropyan、G. B. Ambartsumyan、A. A. Avetisyan、A. S. Galstyan

  DOI：10.1007/s10593-008-0093-6

  日期：2008.6

  The respective hydroxypropyl phenyl ethers were obtained by the reaction of 5,5-dimethylhydantoin, morpholine, benzotriazole, benzimidazole, pyrrolidone, and phthalimide with phenyl glycidyl ether. 8-(2-Hydroxy-3-phenoxy) quinoline was synthesized by O-alkylation.