尼海屈腙 | 67-28-7

• 物质功能分类: 化学试剂 - 有机试剂 - 腙
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 中文名称: 尼海屈腙
• 中文别名: 乙酸,2-[(5-硝基-2-呋喃基)亚甲基](酰)肼
• 英文名称: N’-((5-nitrofuran-2-yl)methylene)acetohydrazide
• 英文别名: N'-((5-nitrofuran-2-yl)methylene)acetohydrazide；n'-[(5-Nitrofuran-2-yl)methylidene]acetohydrazide；N-[(5-nitrofuran-2-yl)methylideneamino]acetamide
• CAS: 67-28-7
• 化学式: C₇H₇N₃O₄
• 分子量: 197.15
• InChiKey: ACFHHZJOAUZSJU-UHFFFAOYSA-N

物化性质

• 沸点：
  334.23°C (rough estimate)
• 密度：
  1.5115 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  尼海屈腙 、 silver nitrate 以 甲醇 、 水 为溶剂， 反应 72.0h， 生成 bis[N'-((5-nitrofuran-2-yl)methylene)acetohydrazide silver(I)]nitrate
  参考文献：
  名称：

  Structural studies and investigation on the antifungal activity of silver(I) complexes with 5-nitrofuran-derived hydrazones

  摘要：

  Silver(I) complexes [Ag(HL1)(2)]NO3 (1), with N'-((5-nitrofuran-2-yl)methylene)acetohydrazide (HL1), and [Ag(HL2)(2)NO3] (2) with N'-((5-nitrofuran-2-yl)methylene)benzohydrazide (HL2) were synthesized. The crystal structures of HL1 and complexes (1) and (2) were determined. The ligands showed no or poor antifungal activity against Candida spp. The silver(I) complexes demonstrated themselves to be more active than silver nitrate and, in some cases, more active than miconazole nitrate and nystatin. (C) 2019 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2019.06.033
• 作为产物：
  描述：

  5-硝基糠醛 、 乙酰肼 以 乙醇 为溶剂， 以78%的产率得到尼海屈腙
  参考文献：
  名称：

  Designing and exploring active N′-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients

  摘要：

  Chagas disease affects around 8 million people worldwide and its treatment depends on only two nitroheterocyclic drugs, benznidazole (BZD) and nifurtimox (NFX). Both drugs have limited curative power in chronic phase of disease. Nifuroxazide (NF), a nitroheterocyclic drug, was used as lead to design a set of twenty one compounds in order to improve the anti-Trypanosoma cruzi activity. Lipinski's rules were considered in order to support drug-likeness designing. The set of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides was assayed against three T. cruzi strains, which represent the discrete typing units more prevalent in human patients: Y (TcII), Silvio X10 cl1 (TcI), and Bug 2149 cl10 (TcV). All the derivatives, except one, showed enhanced trypanocidal activity against the three strains as compared to BZD. In the Y strain 62% of the compounds were more active than NFX. The most active compound was N'((5-nitrofuran-2-yl) methylene)biphenyl-4-carbohydrazide (C20), which showed IC50 values of 1.17 +/- 0.12 mu M; 3.17 +/- 0.32 mu M; and 1.81 +/- 0.18 mu M for Y, Silvio X10 cl1, and Bug 2149 cl10 strains, respectively. Cytotoxicity assays with human fibroblast cells have demonstrated high selectivity indices for several compounds. Exploratory data analysis indicated that primarily topological, steric/geometric, and electronic properties have contributed to the discrimination of the set of investigated compounds. The findings can be helpful to drive the designing, and subsequently, the synthesis of additional promising drugs against Chagas disease. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.03.066

文献信息

• MEDICAL ADHESIVE FOR SURGERY
  申请人：Heckroth Heike

  公开号：US20110245351A1

  公开（公告）日：2011-10-06

  The invention relates to novel rapidly-curing adhesives made from hydrophilic polyisocyanate prepolymers for application in surgery.

  该发明涉及一种用于手术中的新型快速固化胶粘剂，该胶粘剂由亲水性聚异氰酸酯预聚物制成。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Immunogenic composition comprising live encysted protozoa
  申请人：UNILEVER N.V.

  公开号：EP0134703A1

  公开（公告）日：1985-03-20

  An oral vaccine against parasitic protozoa, such as coccidia, comprises live encysted protozoa embedded in a firm gel matrix from which the protozoa are released following ingestion by a host. The gel matrix helps to maintain the essential viability of the protozoa without seriously hindering the natural mechanism by which they infect their host. Preferably the gel matrix is based on alginate. Alginate beadlets containing viable sporulated coccidia oocysts, for administration to poultry, are a preferred feature.

  针对寄生原生动物（如球虫）的口服疫苗由嵌入坚固凝胶基质中的活包囊原生动物组成，宿主摄入后原生动物会从凝胶基质中释放出来。凝胶基质有助于保持原生动物的基本活力，而不会严重妨碍它们感染宿主的自然机制。凝胶基质最好以藻酸盐为基础。藻酸盐微珠含有可存活的孢子化球虫卵囊，可用于家禽饲养。
• Protection of live encysted protozoa
  申请人：UNILEVER PLC

  公开号：EP0294941A1

  公开（公告）日：1988-12-14

  A composition useful in oral immunisation of animals such as poultry comprises dry free-flowing particles each consisting of a solid beadlet of lipid-continuous emulsion containing from about 25% to about 50% by weight water in a lipid, such as hardened palm kernel oil, having a slip point in the range 35 to 45°C, each beadlet having an average diameter of about 2 to 3 millimetres and containing at least 1 viable encysted protozoan, such as a sporulated oocyst of a species of coccidium infective to poultry, each beadlet having a protective coating of animal feed, cement and/or gypsum, the protective coating having an average thickness of about 0.2 to 2mm.

  一种用于家禽等动物口服免疫接种的组合物包括干的自由流动颗粒，每个颗粒由固体微珠组成，微珠为脂质连续乳液，含水量约为 25%至 50%（按重量计），含在脂质（如硬化棕榈仁油）中，滑点在 35 至 45°C 范围内、每个微珠的平均直径约为 2 至 3 毫米，并含有至少 1 个可存活的包囊原生动物，例如可感染家禽的球虫孢子卵囊，每个微珠都有一层动物饲料、水泥和/或石膏保护层，保护层的平均厚度约为 0.2 至 2 毫米。
• Fertilizer composition containing calcium phosphite
  申请人：Baigro Western Sales Inc.

  公开号：EP1655275A2

  公开（公告）日：2006-05-10

  Calcium phosphite containing fertilizers, as well as methods of making and methods of using these fertilizers, are disclosed.

  本文公开了含亚磷酸钙的肥料，以及制造和使用这些肥料的方法。