2-(2-氧代-1,3-苯并噻唑-3(2H)-基)乙酰胺 | 881-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: 2-(2-氧代-1,3-苯并噻唑-3(2H)-基)乙酰胺
• 英文名称: 2-oxo-3(2H)-benzothiazolineacetamide
• 英文别名: 2-(2-oxo-benzothiazol-3-yl)-acetamide；2-(2-oxo-1,3-benzothiazol-3(2H)-yl)acetamide；2-oxo-3-benzothiazoline acetamide；Benzothiazol-2-on-3-yl-acetamid；(2-Oxo-2,3-dihydrobenzothiazol-3-yl)acetamid；2-(2-oxo-1,3-benzothiazol-3-yl)acetamide
• CAS: 881-11-8
• 化学式: C₉H₈N₂O₂S
• 分子量: 208.241
• InChiKey: MRHAAMBNOQKMMW-UHFFFAOYSA-N

物化性质

• 熔点：
  245-247 °C
• 沸点：
  469.8±47.0 °C(Predicted)
• 密度：
  1.446±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  88.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-氧代-1,3-苯并噻唑-3(2H)-基)乙酰胺 在 1,2,3,4-四氢萘 、 phosphorus pentoxide 作用下， 以98%的产率得到2-(2-氧代-1,3-苯并噻唑-3-基)乙腈
  参考文献：
  名称：

  D'Amico, John J.; Marvel, John T.; Bollinger, Frederic G., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1375 - 1378

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-氧代-1,3-苯并噻唑-3-基)乙腈 在 硫酸 作用下， 反应 48.0h， 以64%的产率得到2-(2-氧代-1,3-苯并噻唑-3(2H)-基)乙酰胺
  参考文献：
  名称：

  D'Amico, John J.; Bollinger, Frederick G., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1183 - 1190

  摘要：

  DOI：

文献信息

• N-Hydrazides of 2-benzothiazolinone and their use as plant growth regulants
  申请人：MONSANTO COMPANY

  公开号：EP0002613A1

  公开（公告）日：1979-06-27

  N-Hydrazides of 2-benzothiazolinone have been found to be effective in regulating the growth of leguminous plants. rhese N-hydrazides are characterised by the formula wherein R, is hydroxy lower alkyl or 2-benzothiazolyl; R2 is hydrogen; or R, and R2 when taken together with the adjacent nitrogen form a heterocyclic having up to six carbon atoms, inclusive, and n is an integer from one to four. This invention relates to these N-hydrazides and their use in a method of regulating the growth of leguminous plants as well as to plant growth regulant compositions comprising these N-hydrazides.

  已发现 2-苯并噻唑啉酮的 N-酰肼可有效地调节豆科植物的生长。这些 N-酰肼的特征为：式中 R，为羟基低级烷基或 2-苯并噻唑基；R2 为氢；或 R，和 R2 与邻近的氮一起形成具有最多六个碳原子（含六个碳原子）的杂环；n 为一至四的整数。 本发明涉及这些 N-酰肼及其在豆科植物生长调节方法中的用途，以及包含这些 N-酰肼的植物生长调节剂组合物。
• N-Amides of 2-benzothiazolinone and their use as plant growth regulants
  申请人：MONSANTO COMPANY

  公开号：EP0003075A1

  公开（公告）日：1979-07-25

  N-Amides of 2-benzothiazolinone have been found to be effective in regulating the growth of leguminous plants. The invention relates to a method of regulating the growth of leguminous plants characterised by applying to the plant locus an effective plant growth regulating amount of an N-amide of 2-benzothiazolinone having the formula wherein T is trifluoromethyl and halo, n is 0 or 1; m is an integer from one to four; and R is selected from the group consisting of wherein X and Y are independently selected from the group consisting of hydrogen, halogen, lower alkyl and trifluoromethyl; R1 is hydrogen or lower alkyl; and (II) heterocyclics selected from the group consisting of morpholino, cis- and trans-2,6-dimethylmorpholino, cis- and trans-2,5-dimethylpyrrolidino, 3-azabicycio (3.2.2) nonyl, and ethyl - N-piperazinocarboxylate. The invention also relates to a plant growth regulating composition characterised that said composition comprises from about 5 to 95 parts by weight of a 2-oxo-3-benzothiazoline-acetamide as defined above. Novel 2-oxo-3-benzothiazoline-acetamides are also part of the invention.

  已发现 2-苯并噻唑啉酮的 N-酰胺可有效调节豆科植物的生长。 本发明涉及一种调节豆科植物生长的方法，其特征在于将有效的植物生长调节量的 2-苯并噻唑啉酮的 N-酰胺施用到植物部位，其式为 其中 T 为三氟甲基和卤代，n 为 0 或 1，m 为 1 至 4 的整数，R 选自以下组成的组 其中 X 和 Y 独立地选自氢、卤素、低级烷基和三氟甲基组成的组；R1 是氢或低级烷基；以及 (II) 选自吗啉基、顺式和反式-2,6-二甲基吗啉基、顺式和反式-2,5-二甲基吡咯烷基、3-氮杂双环(3.2.2)壬基和 N-哌嗪甲酸乙酯组成的组的杂环化合物。 本发明还涉及一种植物生长调节组合物，其特征在于所述组合物包含约 5 至 95 重量份的如上定义的 2-氧代-3-苯并噻唑啉-乙酰胺。新型 2-氧代-3-苯并噻唑啉-乙酰胺也是本发明的一部分。
• LEVETIRACETAM FOR IMPROVING COGNITIVE FUNCTION
  申请人：The Johns Hopkins University

  公开号：EP3400934A1

  公开（公告）日：2018-11-14

  This invention relates to methods and compositions for treating central nervous system (CNS) disorders with cognitive impairment. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating central nervous system (CNS) disorders with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease(AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrphic lateral sclerosis and cancer-therapy-related cognitive impairment.

  本发明涉及治疗伴有认知障碍的中枢神经系统（CNS）疾病的方法和组合物。特别是，本发明涉及突触小泡糖蛋白 2A (SV2A)抑制剂单独或与丙戊酸钠联合用于治疗有需要或有风险的受试者（包括但不限于有年龄相关认知障碍或有年龄相关认知障碍风险的受试者）的伴有认知障碍的中枢神经系统 (CNS) 疾病、轻度认知功能障碍（MCI）、失忆性 MCI（aMCI）、年龄相关记忆障碍（AAMI）、年龄相关认知功能衰退（ARCD）、痴呆、阿尔茨海默病（AD）、前驱 AD、创伤后应激障碍（PTSD）、精神分裂症、肌萎缩侧索硬化症和癌症治疗相关认知功能障碍。
• BRIVARACETAM FOR IMPROVING COGNITIVE FUNCTION
  申请人：The Johns Hopkins University

  公开号：EP3827820A1

  公开（公告）日：2021-06-02

  This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease(AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism, compulsive behavior, and substance addiction.

  本发明涉及治疗与中枢神经系统（CNS）疾病相关的认知障碍的方法和组合物。特别是，本发明涉及突触小泡糖蛋白 2A (SV2A)抑制剂单独或与丙戊酸钠联合用于治疗与中枢神经系统 (CNS) 疾病相关的认知功能损害，需要治疗或有治疗风险的受试者包括但不限于有年龄相关认知功能损害、轻度认知功能损害 (MCI) 或有此风险的受试者、老年痴呆症、阿尔茨海默病（AD）、前驱 AD、创伤后应激障碍（PTSD）、精神分裂症、双相情感障碍、肌萎缩性脊髓侧索硬化症、癌症治疗相关认知障碍、智力迟钝、帕金森病、自闭症、强迫行为和药物成瘾。
• Methods and compositions for treating schizophrenia
  申请人：The Johns Hopkins University

  公开号：US10154988B2

  公开（公告）日：2018-12-18

  The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an antipsychotic or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs, and prodrugs thereof. The methods and the compositions can be used for treating one or more positive and/or negative symptoms, as well as cognitive impairment, associated with schizophrenia or bipolar disorder (in particular, mania).

  本发明涉及通过使用突触小泡蛋白2A（SV2A）抑制剂和抗精神病药或其药学上可接受的盐、水合物、溶解物、多晶型物和原药的组合来治疗精神分裂症或躁狂症（尤其是狂躁症）的方法和组合物。这些方法和组合物可用于治疗与精神分裂症或双相情感障碍（尤其是躁狂症）相关的一种或多种阳性和/或阴性症状以及认知障碍。