1-(2,3-dithienylquinoxalin-6-yl)-3-phenylurea | 1023460-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(2,3-dithienylquinoxalin-6-yl)-3-phenylurea
• 英文别名: 1-(2,3-Dithiophen-2-ylquinoxalin-6-yl)-3-phenylurea
• CAS: 1023460-91-4
• 化学式: C₂₃H₁₆N₄OS₂
• 分子量: 428.538
• InChiKey: BHHKGIJJMIHMAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  噻吩偶姻 在 5% Pd(II)/C(eggshell) 、 氢气 、 N,N-二异丙基乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 1-(2,3-dithienylquinoxalin-6-yl)-3-phenylurea
  参考文献：
  名称：

  2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure–activity relationship study

  摘要：

  The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure-activity relationship (SAR). This resulted in the identification of a bisfuranylquinoxalineurea analog (7c) that has low micromolar potency against the panel of cancer cell lines. We also show that cells treated with quinoxalineurea 7c results in caspase 3/7 activation, PARP cleavage and Mcl-1 dependent apoptosis. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.02.055

文献信息

• [EN] COMPOSITIONS AND METHODS FOR INHIBITING ACSS2<br/>[FR] COMPOSITIONS ET MÉTHODES POUR INHIBER ACSS2
  申请人：UNIV PENNSYLVANIA

  公开号：WO2019067528A1

  公开（公告）日：2019-04-04

  The present invention provides compositions and methods for inhibiting ACSS2 for modulating histone acetylation or for treating or preventing a neurological disease or disorder.

  本发明提供了抑制ACSS2以调节组蛋白乙酰化或用于治疗或预防神经系统疾病或紊乱的组合物和方法。
• QUINOXALINE COMPOUNDS AND USES THEREOF
  申请人：Natarajan Amarnath

  公开号：US20130289041A1

  公开（公告）日：2013-10-31

  Disclosed herein are compounds of formula (I) and methods of inhibiting IKKβ and the NF-κB signaling and mTOR pathways.

  本文披露了式(I)化合物以及抑制IKKβ、NF-κB信号通路和mTOR途径的方法。
• COMPOSITIONS AND METHODS FOR INHIBITING ACSS2
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20200291005A1

  公开（公告）日：2020-09-17

  The present invention provides compositions and methods for inhibiting ACSS2 for modulating histone acetylation or for treating or preventing a neurological disease or disorder.
• CANNABIDIOL DERIVATIVES AS INHIBITORS OF THE HIF PROLYL HYDROXYLASES ACTIVITY
  申请人：Emerald Health Pharmaceuticals Inc.

  公开号：US20210317070A1

  公开（公告）日：2021-10-14

  Cannabidiol quinol derivatives of Formula (I) and compositions comprising the same for use in the treatment of conditions that benefit from the inhibition of the HIF prolyl hydroxylases (PHDs) activity are described. Said cannabidiol quinol derivatives of Formula (I), and compositions comprising the same, show thus capacity to inhibit PHD activities and, as a result, stabilize the HIF-1α and HIF-2α levels, activate the HIF pathway in different cell types, induce angiogenesis in human endothelial vascular cell, regulate HIF-dependent gene expression in different cell types and induce collagen contraction. Said cannabidiol quinol derivatives of Formula (I) are useful in the treatment of conditions that benefit from the inhibition of the HIF prolyl hydroxylases (PHDs) activity such as stroke, traumatic injuries anemia, myocardial ischaemia-reperfusion injury, acute lung injury, infectious diseases, diabetic and chronic wounds, organ transplantation, acute kidney injury or arterial diseases.
• US8993758B2
  申请人：——

  公开号：US8993758B2

  公开（公告）日：2015-03-31