benzyl (4-hydroxyphenoxy)acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (4-hydroxyphenoxy)acetate
• 英文别名: Benzyl 4-hydroxyphenoxyacetate；benzyl 2-(4-hydroxyphenoxy)acetate
• 化学式: C₁₅H₁₄O₄
• mdl: MFCD26384553
• 分子量: 258.274
• InChiKey: WLNOIOUGLBDZHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl (4-hydroxyphenoxy)acetate 、 Chlorooxalyl-methyl-carbamic acid 2,2-dimethyl-2,3-dihydro-benzofuran-7-yl ester 在 三乙胺 作用下， 以 乙醚 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel N-Oxalyl-N-methylcarbamates

  摘要：

  A series of novel 2,3-dihydro-2,2-dimethyl-7-benzofuranyl N-oxalyl-N-methylcarbamate insecticides (N-oxalyl derivatives of carbofuran) containing carboxylic acid or carboxylate substituent were prepared. N-Oxalyl derivatives of carbofuran were examined for toxicity to white mice and a wide variety of economically important pests and for systemic activity in plants. Compared to the parent insecticide, carbofuran, the derivatives displayed significantly reduced toxicity to the white mouse. Two of the derivatives [oxamic acid, carboxymethyl-, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl) ester, ester with methyl salicylate, compound 1; and oxamic acid, carboxymethyl-, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl) ester, ester with methyl p-hydroxybenzoate, compound 8] showed 700-1000 times less toxicity to the mouse than the nonderivatized carbofuran on a weight basis. All of the derivatives were highly effective insecticides against a wide variety of insects. The derivatives also displayed a wide spectrum of systemic pesticide activity comparable or superior to carbofuran in the cut stem, soil, and foliar applications.

  DOI：

  10.1021/jf00040a035
• 作为产物：
  描述：

  草酰氯 、 4-羟基苯氧乙酸 在 白碳黑 苯甲醇 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 以25%的产率得到benzyl (4-hydroxyphenoxy)acetate
  参考文献：
  名称：

  Water-soluble derivatives of epipodophyllotoxin, process for their

  摘要：

  表达为中文：依托草酮的水溶性衍生物，其制备方法及其用于治疗类风湿性关节炎、人类乳头瘤病毒引起的疾病和癌症的用途。

  公开号：

  US06107284A1

文献信息

• 5-membered heterocycles, medicaments containing these compounds, their
  申请人：Dr. Karl Thomae GmbH

  公开号：US05817677A1

  公开（公告）日：1998-10-06

  5-Membered heterocyclic compounds, of which the following compounds are exemplary: (a) 4-\x9b\x9btrans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imida zole, (b) 5-\x9b\x9btrans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperi dyl)-1,3-thiazole, (c) 5-\x9b\x9b4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-t hiazole, (d) 5-\x9b\x9btrans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3, 4-thiadiazole, (e) 5-\x9b\x9b4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiaz ole, (f) 5-\x9b\x9btrans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3- thiazole, (g) 5-\x9b\x9b4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (h) 5-\x9b\x9btrans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3- thiazole, and (i) 4-\x9b\x9btrans-4-carboxycyclohexyl!aminocarbonyl!-1-\x9b2-(4-piperidyl)ethyl!imida zole. These are useful for the treatment or prevention of illnesses in which relatively small or relatively large cell aggregates occur or cell-matrix interactions play a part.

  五元杂环化合物，以下化合物为示例：(a) 4-反式-4-(2-羧乙基)环己基氨基甲酰-1-(4-哌啶基)咪唑，(b) 5-反式-4-(2-羧乙基)环己基氨基甲酰-4-甲基-2-(4-哌啶基)-1,3-噻唑，(c) 5-4-(羧甲氧基)苯基氨基甲酰-4-甲基-2-(4-哌啶基)-1,3-噻唑，(d) 5-反式-4-(2-羧乙基)环己基氨基甲酰-2-(4-哌啶基)-1,3,4-噻二唑，(e) 5-4-(羧甲氧基)苯基氨基甲酰-2-(4-哌啶基)-1,3,4-噻二唑，(f) 5-反式-4-(羧甲氧基)环己基氨基甲酰-2-(4-哌啶基)-1,3-噻唑，(g) 5-4-(羧甲氧基)苯基氨基甲酰-2-(4-哌啶基)-1,3-噻唑，(h) 5-反式-4-(2-羧乙基)环己基氨基甲酰-2-(4-哌啶基)-1,3-噻唑，和(i) 4-反式-4-羧基环己基氨基甲酰-1-2-(4-哌啶基)乙基咪唑。这些化合物对治疗或预防相对较小或相对较大的细胞聚集或细胞-基质相互作用起作用的疾病是有用的。
• US6107284A
  申请人：——

  公开号：US6107284A

  公开（公告）日：2000-08-22