2-hydroxymethyl-1-(N-phthaloylalanyl)aziridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-hydroxymethyl-1-(N-phthaloylalanyl)aziridine
• 英文别名: 2-[1-[2-(Hydroxymethyl)aziridin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione
• 化学式: C₁₄H₁₄N₂O₄
• 分子量: 274.276
• InChiKey: DJOLKHJSOVXZPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  77.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-苯二甲酰亚氨基丙酸 在 氯化亚砜 、 sodium hydride 、 N,N-二甲基甲酰胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 2-hydroxymethyl-1-(N-phthaloylalanyl)aziridine
  参考文献：
  名称：

  The synthesis of N -acyl-2-hydroxymethyl aziridines of biological interest

  摘要：

  A practical synthesis of the title compounds from protected amino acylazides is described. All the compounds might be considered as a novel class of dipeptide isostere precursors; they all induce lymphocyte proliferation and protein production as observed from preliminary biological tests. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.136

文献信息

• The synthesis of N -acyl-2-hydroxymethyl aziridines of biological interest
  作者：W. Medjahed、A. Tabet Zatla、J. Kajima Mulengi、F.Z. Baba Ahmed、H. Merzouk

  DOI：10.1016/j.tetlet.2003.11.136

  日期：2004.2

  A practical synthesis of the title compounds from protected amino acylazides is described. All the compounds might be considered as a novel class of dipeptide isostere precursors; they all induce lymphocyte proliferation and protein production as observed from preliminary biological tests. (C) 2003 Elsevier Ltd. All rights reserved.