cis-[bis(triphenylphosphane)bis(acetato)platinul(II)] | 656813-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-[bis(triphenylphosphane)bis(acetato)platinul(II)]
• 英文别名: cis-bis(triphenylphosphine)diacetatoplatinum(II)；cis-[Pt(CH3COO)2(PPh3)2]；cis-[Pt(AcO)2(PPh3)2]；cis-[Pt(OAc)2(PPh3)2]；platinum(2+);triphenylphosphane;diacetate
• CAS: 656813-25-1
• 化学式: C₄₀H₃₆O₄P₂Pt
• 分子量: 837.751
• InChiKey: BCGILGBSMBJGOE-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  47
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cis-[bis(triphenylphosphane)bis(acetato)platinul(II)] 在 CO 、 MeOH 作用下， 以 甲醇 为溶剂， 以45%的产率得到trans-[(Ph3P)2Pt(CO2CH3)2]
  参考文献：
  名称：

  Synthesis and reactivity of N-acetylamino acidate(2–) and related complexes of platinum(II)

  摘要：

  Treatment of the complexes [PtCl2L2](L = P-donor ligand) with the N-acetyl derivatives of the amino acids glycine, DL-alanine, DL-methionine or L-phenylalanine in the presence of an excess of silver(I) oxide in refluxing dichloromethane affords [Pt{N(COMe)CHRC(O)O}L2] (R = H, Me, CH2CH2SMe or CH2Ph) respectively, and with L-proline the complexes [Pt{NCH2CH2CH2CHC(O)O}L2] are produced, Similar treatment with the N-formyl or N-trifluoroacetyl derivatives of glycine gave the complexes [Pt{N(R)CH2C(O)}2] (R = CHO or COCF3) respectively. An X-ray crystal structure study on the N-acetylglycinato(2-)-N,O complex [Pt{N(COMe)CH2C(O)O}(dppe)] (dppe = Ph2PCH2CH2PPh2) indicated the presence of an almost planar five-membered ring with substantial electron delocalisation within the carboxylate and amide functionalities. Treatment of the complexes [PtCl2L2] with DL-mandelic (alpha-hydroxybenzeneacetic) acid, 2-acetamidophenol, pyrrole-2-carboxylic acid, mercaptoacetic acid or oxamic acid in the presence of an excess of Ag2O in refluxing dichloromethane afforded the complexes [Pt{OC(H)PhC(O)O}L2], [Pt{o-N(COMe)C6H4O}L2], [Pt{NCH = C(H)CH = CC(O)O}L2], [Pt{SCH2C(O)O}L2], [Pt{N(H)C(O)C(O)O}L2] respectively. The cycloocta-1,5-diene (cod) ligand of [Pt{N(COMe)CH2C(O)O}(cod)] and [Pt{N(COMe)CH(CH2Ph)C(O)O}(cod)] is readily displaced by tertiary phosphines. One mole equivalent of Bu(t)NC stereospecifically displaces the PPh3 ligand opposite oxygen in the complex [Pt{N(COMe)CH(CH2Ph)C(O)P}(PPh3)2]. Treatment of [Pt{N(COMe)CH2C(O)O}(PPh3)2] in refluxing ethanol with an excess of either diphenylacetylene or PPh3 leads to the formation of [Pt(PhC = CPh)(PPh3)2] or [Pt(PPh3)4] respectively, in good yield. Treatment of the same metal complex in ethanol at room temperature with either SO2 or CO led to the formation of the bis(ethanesulfonate) or bis(ethoxycarbonyl) complexes respectively. The complex [Pt{NCHCH2CH2CHC(O)O}(PPh3)2] induces the polymerisation of hexaflurobut-2-yne.

  DOI：

  10.1039/dt9920001165
• 作为产物：
  描述：

  triacetatoargento(I)triphenylphosphineplatinum(II) 在 PPh₃ 、 Re(CO)5Br 作用下， 以 溶剂黄146 为溶剂， 生成 cis-[bis(triphenylphosphane)bis(acetato)platinul(II)]
  参考文献：
  名称：

  Re(III) complexes in the synthesis of platinum acetate complexes and the structure of [PPh3Pt(OAc)2]2

  摘要：

  DOI：

  10.1007/bf00956965
• 作为试剂：
  描述：

  (Z)-3-benzyloxymethyl-3,5,5-trimethyl-6-octen-1-yne 在 cis-[bis(triphenylphosphane)bis(acetato)platinul(II)] 三氟乙酸 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 5-benzyloxymethyl-1-<(Z)-1-propenyl>-3,5,5-trimethylcyclopentene 、 5-benzyloxymethyl-1-<(E)-1-propenyl>-3,3,5-trimethylcyclopentene
  参考文献：
  名称：

  An Approach to Botrydianes: On the Steric Demands of a Metal Catalyzed Enyne Metathesis

  摘要：

  测试了过渡金属催化的炔烃偏析作为 1-烯基环烷烃合成的合成范围。由于过渡金属催化反应对立体效应非常敏感，因此与通常的预期相反，严重的立体拥塞会增强反应的效果。虽然钯基催化剂通常更受青睐，但铂催化剂也会影响这些新型环排列。

  DOI：

  10.1055/s-1993-25950

文献信息

• Insertion of carbon dioxide, of Co₂-like molecules, and of other unsaturated compounds into the platinum–nitrogen bond of [Pt(PPh₃)₂(PhNO)]
  作者：Sergio Cenini、Francesca Porta、Maddalena Pizzotti、Corrado Crotti

  DOI：10.1039/dt9850000163

  日期：——

  omitted]}(PPh3)2](5), respectively have been obtained. Compound (2) is an isomer of the insertion product (6), [[graphic omitted]}(PPh3)2], obtained from the reaction of [Pt(PPh3)2(O2)] with PhNCO. A labile insertion product, [[graphic omitted]}(PPh3)2], (7), was obtained by reaction of (1) with PhCHO, while no reaction was observed between (1) and acetone or diethyl carbonate. However, compound (1) reacts

  化合物[Pt（PPh 3）2（PhNO）]（1）与二氧化碳可逆反应，得到[[省略图示]}（PPh 3）2 ]（2）。其他类似CO 2的分子容易且不可逆地插入（1）的铂-氮键中；与CS 2，PhNCO和PhNCS对应的1：1加合物[[省略图示]}（PPh 3）2 ]（3），[[省略图示]}（PPh 3）2 ]（4）和[[图示省略]}（PPh 3）2 ]（5），分别已获得。化合物（2）是由[Pt（PPh 3）2（O 2）]与PhNCO反应获得的插入产物（6）的异构体[[省略图示]}（PPh 3）2 ] 。不稳定的插入产品，[[图形省略]}（PPH 3）2 ]，（7通过的（反应获得），1与苯甲醛），而在（之间没有观察到反应1）和丙酮或碳酸二乙酯。但是，化合物（1）与EtO 2 C–N N–CO 2反应等式给出取代产物（8），[[省略图示]}（PPh 3）2 ]。已经研究了化合物（2）对无机酸，有
• cis Influence in trans-Pt(PPh₃)₂complexes
  作者：Luca Rigamonti、Carlo Manassero、Michele Rusconi、Mario Manassero、Alessandro Pasini

  DOI：10.1039/b813125b

  日期：——

  The cis influence of a series of anionic ligands X and Y has been evaluated through the magnitude of the Pt–P coupling constants for compounds of formula trans-[PtXY(PPh3)2]. The order of decreasing cis influence was found to be I > Cl > SePh ∼ SPh ∼ SEt > NO3 > AcO ∼ NO2 > H > Me > Ph > mtc (mtc = N,N-dimethylmonothiocarbamato-S); moreover, the cis influences of the various ligands was found to be additive. The X-ray structures of three representative compounds (t-4: X = Cl, Y = NO3; t-5: X = Cl, Y = AcO and t-12: X = Y = NO2) have also been determined.

  一系列阴离子配体X和Y的顺式影响通过化合物trans-[PtXY(PPh3)2]的Pt–P耦合常数的大小进行了评估。顺式影响的递减顺序为I > Cl > SEPh ∼ SPh ∼ SEt > NO3 > AcO ∼ NO2 > H > Me > Ph > mtc（mtc = N,N-二甲基单硫氨基甲酸盐-S）；此外，各种配体的顺式影响被发现是可相加的。三种代表性化合物的X射线结构（t-4: X = Cl, Y = ；t-5: X = Cl, Y = AcO；t-12: X = Y = ）也已被确定。
• The Role of Anions in Addressing the Outcome of the Reaction of Tetramethylthiourea with <i>cis</i> ‐Pt ^II (phos) ₂ Moieties (phos = PPh ₃ or ${1 \over 2}$dppe), Cyclometallation vs. Hydrolysis to Monothiocarbamato, and the Crystal Structure of <i>trans</i> ‐Bis( <i>N</i> ‐dimethylmonothiocarbamato)bis(triphenylphosphane)platinum( <scp>II</scp> )
  作者：Maria Alesi、Serena Fantasia、Mario Manassero、Alessandro Pasini

  DOI：10.1002/ejic.200500892

  日期：2006.4

  The product of the reaction between tetramethylthiourea (tmtu) and cis-PtII(phos)2 moieties (phos = PPh3, or dppe)depends on the anionic species present. With NO3–, CF3CO2–,CF3SO3– and BF4–, the cyclometallate cationic complex [Pt(phos)2(tmtu*-C,S)]+ is obtained (tmtu* is tmtu deprotonated at one methyl group). The acetato and malonato complexes are inactive towards such deprotonation, but, in the

  四甲基硫脲 (tmtu) 和顺式 PtII(phos)2 部分（phos = PPh3 或 dppe）之间的反应产物取决于存在的阴离子物质。使用 NO3–、CF3CO2–、CF3SO3– 和 BF4–，得到环金属阳离子络合物 [Pt(phos)2(tmtu*-C,S)]+（tmtu* 是在一个甲基上去质子化的 tmtu）。乙酰基和丙二酸根络合物对这种去质子化无活性，但在水的存在下，促进 tmtu 水解，形成 N-二甲基单硫代氨基甲酸 (mtc) 络合物，其中 mtc 是 S 配位的。顺式-[Pt(PPh3)2(mtc)2] 异构化为反式异构体，其晶体结构已报告。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
• PLATINUM COMPLEX, ITS PREPARATION AND THERAPEUTIC USE
  申请人：City University

  公开号：US20210371441A1

  公开（公告）日：2021-12-02

  A platinum complex comprises a chemical structure of Structure I: where L 1 and L 2 are independently selected from electron donor ligands, including but not limited to halogen ligands, hydroxo ligands, carboxylato ligands, and alkoxido ligands; R 1 , R 2 and R 3 are each independently selected from a hydrogen atom, hydrocarbon group, or heterocyclic group; wherein the hydrocarbon group is selected from: alkyl, alkenyl, cycloalkyl, phenyl, and naphthyl which may optionally be substituted by at least one functional group selected from the group consisting of: hydroxy, halogen, alkoxy, alkoxycarbonyl, carboxy, amido, amino, nitro, cyano, carbamate, urea, sulfonyl, sulfenyl, phosphenyl, phosphinyl, sulfide, thioether, thioester, sugar moiety, cyclodextrin, or porphyrin ring; and the heterocyclic group is selected from: pyridyl, piperidyl, azino, azolyl, imidazolyl, triazinyl, furyl or carbozolyl; or two adjacent R 1 , R 2 and R 3 groups form a heterocycle or a carbocycle with or without an intermediary hetero atom or intermediary hetero atoms.

  一种铂配合物包括化学结构I，其中L1和L2是独立选择的电子给体配体，包括但不限于卤素配体、羟基配体、羧基配体和烷氧基配体；R1、R2和R3分别是独立选择的氢原子、烃基或杂环基；其中烃基选自：烷基、烯基、环烷基、苯基和萘基，可选择地被至少一个官能团取代，所述官能团选自羟基、卤素、烷氧基、烷氧羰基、羧基、酰胺基、氨基、硝基、氰基、氨基甲酸酯、脲、磺酰基、烷基硫基、膦基、硫醚、硫酯、糖基、环糊精或卟啉环；所述杂环基选自：吡啶基、哌啶基、咪唑基、三嗪基、呋喃基或卡波佐基；或者相邻的R1、R2和R3基与中间的杂原子或杂原子形成杂环或碳环。
• Synthesis of a platinum(0) ethylene complex by the hydrazine method
  作者：V. V. Bashilov、V. I. Sokolov

  DOI：10.1007/bf00955386

  日期：1986.5