(2,4-dichlorobenzylidene)furan-2-carbohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,4-dichlorobenzylidene)furan-2-carbohydrazide
• 英文别名: N-[(2,4-dichlorophenyl)methylideneamino]furan-2-carboxamide
• 化学式: C₁₂H₈Cl₂N₂O₂
• 分子量: 283.114
• InChiKey: SISNXEYHQJTARM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2,4-dichlorobenzylidene)furan-2-carbohydrazide 、 三苄基氯化锡 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以75%的产率得到[(2,4-dichlorobenzylidene)furan-2-carbohydrazide] tribenzyltin(IV)
  参考文献：
  名称：

  Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues

  摘要：

  A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogues (I-a-I-c) have been synthesized and then complexed with organotin(IV) moiety having general formula [R'(3) SnL] to get the target compounds(1-9), where L = C4H3OCONHN=CHR, R = C6H5O(I-a), C4H5O(I-b), C6H3Cl2(I-c) and R' = -CH3(1-3), -CH2Ph(4-6), -Ph(7-9). They were fully characterized using FT-IR, NMR(H-1, C-13 and Sn-119) spectroscopy, along with elemental analysis and melting point. One of the precursor (I-b) has been analyzed by single crystal XRD to further authenticate the structure. The Sn-119 NMR data suggest the molecular geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, alpha-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.

  DOI：

  10.1016/j.ica.2018.10.009
• 作为产物：
  描述：

  2-呋喃甲酰肼 、 2,4-二氯苯甲醛 以 乙醇 为溶剂， 以80%的产率得到(2,4-dichlorobenzylidene)furan-2-carbohydrazide
  参考文献：
  名称：

  Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues

  摘要：

  A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogues (I-a-I-c) have been synthesized and then complexed with organotin(IV) moiety having general formula [R'(3) SnL] to get the target compounds(1-9), where L = C4H3OCONHN=CHR, R = C6H5O(I-a), C4H5O(I-b), C6H3Cl2(I-c) and R' = -CH3(1-3), -CH2Ph(4-6), -Ph(7-9). They were fully characterized using FT-IR, NMR(H-1, C-13 and Sn-119) spectroscopy, along with elemental analysis and melting point. One of the precursor (I-b) has been analyzed by single crystal XRD to further authenticate the structure. The Sn-119 NMR data suggest the molecular geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, alpha-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.

  DOI：

  10.1016/j.ica.2018.10.009

文献信息

• Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues
  作者：Mehwish Mehmood、Imtiaz-ud-Din、Muhammad Nawaz Tahir、Ihsan-ul Haq、Syeda Saniya Zahra

  DOI：10.1016/j.ica.2018.10.009

  日期：2019.2

  A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogues (I-a-I-c) have been synthesized and then complexed with organotin(IV) moiety having general formula [R'(3) SnL] to get the target compounds(1-9), where L = C4H3OCONHN=CHR, R = C6H5O(I-a), C4H5O(I-b), C6H3Cl2(I-c) and R' = -CH3(1-3), -CH2Ph(4-6), -Ph(7-9). They were fully characterized using FT-IR, NMR(H-1, C-13 and Sn-119) spectroscopy, along with elemental analysis and melting point. One of the precursor (I-b) has been analyzed by single crystal XRD to further authenticate the structure. The Sn-119 NMR data suggest the molecular geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, alpha-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.