R-PhS(O)Me | 1193-82-4

• 物质功能分类: 化学试剂 - 有机试剂 - 硫醇/硫酚
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: R-PhS(O)Me
• 英文别名: (R)-(Methylsulfinyl)benzene；[(R)-methylsulfinyl]benzene
• CAS: 1193-82-4
• 化学式: C₇H₈OS
• 分子量: 140.206
• InChiKey: JXTGICXCHWMCPM-SECBINFHSA-N

物化性质

• 熔点：
  26-29 °C (lit.)
• 沸点：
  139-140 °C/14 mmHg (lit.)
• 密度：
  1.1182 (rough estimate)
• 闪点：
  187 °F

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S22,S24/25
• 危险类别码：
  R37/38,R41
• WGK Germany：
  3
• 海关编码：
  2930909090
• 危险标志：
  GHS05,GHS07
• 危险性描述：
  H315,H318,H335
• 危险性防范说明：
  P261,P280,P305 + P351 + P338
• 包装等级：
  III
• 危险类别：
  8
• 危险品运输编号：
  1760

反应信息

• 作为产物：
  描述：

  茴香硫醚 在 μ-Oxido-bis({R(-)-2-[(1-oxido-2-phenylethyl)iminomethyl]-4-bromophenolato-κ³N,O,O'}oxidovanadium(V)) 、 双氧水 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.5h， 以92%的产率得到R-PhS(O)Me
  参考文献：
  名称：

  Oxidovanadium(V) complexes with chiral tridentate Schiff bases derived from R(−)-phenylglycinol: Synthesis, spectroscopic characterization and catalytic activity in the oxidation of sulfides and styrene

  摘要：

  A series of vanadium(V) complexes with chiral tridentate Schiff base ligands, obtained by the single condensation of R(-)-phenylglycinol with salicylaldehyde and its derivatives, were prepared. The complexes were characterized by elemental analysis and by their ESI-MS, IR, CD, UV-Vis, 1D (H-1, V-51) and 2D (COSY, gHSQC) NMR spectra. The vanadium(V) complexes have the ability to catalyze the oxidation of sulfides [PhSR (R = Me, Bz)] in excellent yields and enantiomeric excesses (over 90%), utilizing aqueous 30% H2O2 or cumene hydroperoxide (CHP) as the oxidant. These complexes are also catalytically active in the oxidation of styrene, using aqueous 30% H2O2 or tert-butyl hydroperoxide (TBHP) as the oxidant, to styrene oxide, benzaldehyde, benzoic acid, phenylacetaldehyde and 1-phenylethane-1,2-diol. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.12.038

文献信息

• ONIUM SALT COMPOUND, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20210179554A1

  公开（公告）日：2021-06-17

  An onium salt having formula (1) serving as an acid diffusion inhibitor and a chemically amplified resist composition comprising the acid diffusion inhibitor are provided. When processed by lithography, the resist composition exhibits a high sensitivity, and excellent lithography performance factors such as CDU and LWR.

  提供一种具有化学式（1）的醇铵盐，用作酸扩散抑制剂，以及包括该酸扩散抑制剂的化学增强型抗蚀剂组合物。当通过光刻加工时，该抗蚀剂组合物表现出高灵敏度和优异的光刻性能因素，例如CDU和LWR。
• Chiral Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex
  申请人：HORMANN Robert Eugene

  公开号：US20120116090A1

  公开（公告）日：2012-05-10

  The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.

  本发明提供了用于基于蜕皮激素受体的诱导基因表达系统的二酰肼配体和手性二酰肼配体。因此，本发明适用于基因治疗、大规模蛋白质和抗体生产、基于细胞的筛选分析、功能基因组学、蛋白质组学、代谢组学和转基因生物特征调控等应用中，其中需要控制基因表达水平。本发明的优点在于提供了一种调节基因表达并根据用户要求定制表达水平的手段。
• Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
  申请人：Hormann Robert Eugene

  公开号：US20090163592A1

  公开（公告）日：2009-06-25

  The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.

  本发明提供了用于基于蜕皮激素受体诱导基因表达系统的二酰肼配体和手性二酰肼配体。因此，本发明可用于基因治疗、大规模蛋白质和抗体生产、细胞筛选分析、功能基因组学、蛋白质组学、代谢组学和转基因生物特征调控等应用中，其中需要控制基因表达水平。本发明的优点是提供了一种调节基因表达并根据用户要求调整表达水平的手段。
• Synthesis of isotopically labeled R- or S-[13C, 2H] glycerols
  申请人：Martinez A. Rodolfo

  公开号：US20050027146A1

  公开（公告）日：2005-02-03

  The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two 13 C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S)[1,2- 13 C 2 ]glycerol and (2R)[1,2- 13 C 2 ]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.

  本发明涉及不对称手性标记甘油，包括至少一个手性原子，从一个到两个13C原子和从零到四个氘原子直接连接到碳原子，例如(2S)[1,2-13C2]甘油和(2R)[1,2-13C2]甘油，以及在制备标记氨基酸时使用这种手性甘油的方法。
• Process for the asymmetric oxidation of organic compounds with peroxides in the presence of a chiral acid catalyst
  申请人：Studiengesellschaft Kohle mbH

  公开号：EP2615083A1

  公开（公告）日：2013-07-17

  The present invention relates to a process for the asymmetric oxidation of organic compounds, particularly metal-free, with peroxide compounds in the presence of a chiral Brønsted acid catalyst. In one detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral imidodiphosphate catalyst. In another detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral phosphoric acid catalyst.

  本发明涉及一种在手性勃氏酸催化剂存在下用过氧化物化合物对有机化合物，特别是无金属化合物进行不对称氧化的工艺。在一个细节中，本发明涉及一种在手性亚胺二磷酸盐催化剂存在下用过氧化物化合物对硫代化合物进行对映选择性硫氧化的工艺。在另一个细节中，本发明涉及一种硫代化合物与过氧化物在手性磷酸催化剂存在下进行对映选择性硫氧化的工艺。