N-propyl-4-phenyl-2-butylamine | 68164-01-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-propyl-4-phenyl-2-butylamine
• 英文别名: α-methyl-N-propyl-benzenepropanamine；N-Propyl-1-methyl-3-phenylpropylamin；4-phenyl-N-propylbutan-2-amine
• CAS: 68164-01-2
• 化学式: C₁₃H₂₁N
• 分子量: 191.316
• InChiKey: QLKUQHFCOVJVTH-UHFFFAOYSA-N

物化性质

• 沸点：
  92-94 °C(Press: 1 Torr)
• 密度：
  0.9017 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-methylene-2-phenylcyclopropane 在 palladium on activated charcoal (pentamethylcyclopentadienyl)2SmCH(TMS)2 、 氢气 作用下， 以 四氢呋喃 、 氘代苯 为溶剂， 20.0~60.0 ℃ 、101.33 kPa 条件下， 反应 72.0h， 生成 N-propyl-4-phenyl-2-butylamine
  参考文献：
  名称：

  烯烃、炔烃、乙烯基芳烃、二乙烯基芳烃和三乙烯基芳烃以及亚甲基环丙烷的有机乙醇催化区域选择性分子间加氢胺化。分子内环氢胺化的范围和机理比较

  摘要：

  Cp'(2)LnCH(SiMe(3))(2) (Cp' = eta(5)-Me(5)C(5); Ln = La, Nd, Sm, Lu) 和 Me 类型的有机镧系元素配合物(2)SiCp' '(2)LnCH(SiMe(3))(2) (Cp' ' = eta(5)-Me(4)C(5); Ln = Nd, Sm, Lu) 作为有效的预催化剂用于炔烃 R'Ctbd1;CMe (R' = SiMe(3), C(6)H(5), Me) 的区域选择性分子间加氢胺化，烯烃 RCH=CH(2) (R = SiMe(3), CH( 3)CH(2)CH(2)), 丁二烯, 乙烯基芳烃 ArCH=CH(2) (Ar = 苯基, 4-甲基苯, 萘基, 4-氟苯, 4-(三氟甲基)苯, 4-甲氧基苯, 4-(二甲氨基)苯、4-(甲硫基)苯)、二-和三乙烯基芳烃，以及具有伯胺R''NH(2)的亚甲基环丙烷(R''=正

  DOI：

  10.1021/ja035867m

文献信息

• The reductive amination of aldehydes and ketones by catalytic use of dibutylchlorotin hydride complex
  作者：Hirofumi Kato、Ikuya Shibata、Yuta Yasaka、Shinji Tsunoi、Makoto Yasuda、Akio Baba

  DOI：10.1039/b610614e

  日期：——

  The reductive amination of aldehydes or ketones using Ph(2)SiH(2) or PhSiH(3) has been effectively promoted by the direct use of Bu(2)SnClH-pyridine N-oxide as a catalyst; this method has advantages in terms of its mild conditions and wide application to various carbonyls and amines, including aliphatic examples.

  通过直接使用Bu（2）SnClH-吡啶N-氧化物作为催化剂有效地促进了使用Ph（2）SiH（2）或PhSiH（3）进行醛或酮的还原胺化；该方法在温和条件和广泛应用于各种羰基和胺（包括脂肪族实例）方面具有优势。
• Amine derivative with potassium channel regulatory function, its preparation and use
  申请人：——

  公开号：US20040266822A1

  公开（公告）日：2004-12-30

  The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression. 1

  本发明提供了由式I表示的胺衍生物，其异构体、拉克酸盐或光学异构体，其酰胺或酯，以及含有该化合物的制药组合物及其制备方法。本发明还涉及上述化合物在预防或治疗心血管疾病、糖尿病、支气管和尿道平滑肌痉挛以及缺血性和缺氧性神经损伤的药物制剂中的应用。上述化合物可用于治疗高血压、心绞痛、心肌梗死、充血性心力衰竭、心律失常、糖尿病、痉挛性支气管疾病、痉挛性膀胱或输尿管疾病以及抑郁症。
• AMINE DERIVATIVE WITH POTASSIUM CHANNEL REGULATORY FUNCTION, ITS PREPARATION AND USE
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A.

  公开号：EP1386908A1

  公开（公告）日：2004-02-04

  The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

  本发明提供了式 I 所代表的胺衍生物、其异构体、外消旋体或光学异构体、其药用盐、其酰胺或酯、含有上述化合物的药物组合物及其制备方法。本发明还涉及上述化合物在制备预防或治疗心血管疾病、糖尿病、支气管和泌尿道平滑肌痉挛以及缺血和缺氧性神经损伤的药物中的用途。上述化合物可用于治疗高血压、膈心绞痛、心肌梗塞、充血性心力衰竭、心律失常、糖尿病、痉挛性支气管疾病、痉挛性膀胱或输尿管疾病以及抑郁症。
• KOZLOV, N. S.;MOJSEENOK, L. I.;GLADKIX, N. N.;KOZINTSEV, S. I.;GLADKIX, L+, DOKL. AN BSSR, 1983, 27, N 6, 532-535
  作者：KOZLOV, N. S.、MOJSEENOK, L. I.、GLADKIX, N. N.、KOZINTSEV, S. I.、GLADKIX, L+

  DOI：——

  日期：——
• US7560473B2
  申请人：——

  公开号：US7560473B2

  公开（公告）日：2009-07-14