tert-butyl N-[[2-hydroxy-3-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]methyl]carbamate | 481633-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: tert-butyl N-[[2-hydroxy-3-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]methyl]carbamate
• CAS: 481633-15-2
• 化学式: C₁₈H₂₈N₂O₅
• 分子量: 352.431
• InChiKey: FEFONKCUACZWTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  96.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[[2-hydroxy-3-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]methyl]carbamate 在 TEA 、 苯甲醚 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-Butyl-3-{3-[(3-butyl-thioureido)-methyl]-2-hydroxy-benzyl}-thiourea
  参考文献：
  名称：

  Anion sensor based on the indoaniline–thiourea system

  摘要：

  A new chromogenic indoaniline-thiourea-based sensor was designed to recognize anions in an organic solvent through complementary intermolecular hydrogen bonding. Complexed anions cause significant disturbance to the intramolecular hydrogen-bonded structure of the sensor, which then induces color and UV-vis spectral changes. This sensor allows for selective colorimetric detection of tetrahedral oxoanions (HSO4- and H2PO4-). (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01455-7
• 作为产物：
  描述：

  Acetic acid 2,6-bis-azidomethyl-phenyl ester 在 lithium aluminium tetrahydride 、 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 tert-butyl N-[[2-hydroxy-3-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]methyl]carbamate
  参考文献：
  名称：

  Selective anion sensing based on a dual-chromophore approach

  摘要：

  新型阴离子传感器 1 以偶氮苯酚和对硝基苯基为发色团，可以轻松比色区分碱度相似的 F-、H2PO4- 和 AcO-。

  DOI：

  10.1039/b102187g

文献信息

• Muche, Marc-Steffen; Goebel, Michael W., Angewandte Chemie, 1996, vol. 108, # 18, p. 2263 - 2265
  作者：Muche, Marc-Steffen、Goebel, Michael W.

  DOI：——

  日期：——
• An Azophenol-Based Chromogenic Anion Sensor
  作者：Dong Hoon Lee、Kwan Hee Lee、Jong-In Hong

  DOI：10.1021/ol006690t

  日期：2001.1.1

  [GRAPHICS]A new chromogenic azophenol-thiourea based anion sensor, 2, has been developed. This system allows for the selective colorimetric detection of F-, H2PO4-, and AcO-. Selectivity trends turned out to be dependent upon guest basicity and conformational complementarity between 2 and the guest.
• Selective anion sensing based on a dual-chromophore approach
  作者：Dong Hoon Lee、Ho Yong Lee、Kwan Hee Lee、Jong-In Hong

  DOI：10.1039/b102187g

  日期：——

  A new anion sensor 1 with an azophenol and p-nitrophenyl moieties as chromophores allows for easy colorimetric differentiation of F−, H2PO4− and AcO− with similar basicity.

  新型阴离子传感器 1 以偶氮苯酚和对硝基苯基为发色团，可以轻松比色区分碱度相似的 F-、H2PO4- 和 AcO-。
• Anion sensor based on the indoaniline–thiourea system
  作者：Dong Hoon Lee、Ho Yong Lee、Jong-In Hong

  DOI：10.1016/s0040-4039(02)01455-7

  日期：2002.9

  A new chromogenic indoaniline-thiourea-based sensor was designed to recognize anions in an organic solvent through complementary intermolecular hydrogen bonding. Complexed anions cause significant disturbance to the intramolecular hydrogen-bonded structure of the sensor, which then induces color and UV-vis spectral changes. This sensor allows for selective colorimetric detection of tetrahedral oxoanions (HSO4- and H2PO4-). (C) 2002 Elsevier Science Ltd. All rights reserved.