2,3-epoxypropyl-4-methoxybenzyl ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-epoxypropyl-4-methoxybenzyl ether
• 英文别名: 2-[[5-Methoxy-2-[[4-methoxy-2-(oxiran-2-ylmethyl)phenyl]methoxymethyl]phenyl]methyl]oxirane；2-[[5-methoxy-2-[[4-methoxy-2-(oxiran-2-ylmethyl)phenyl]methoxymethyl]phenyl]methyl]oxirane
• 化学式: C₂₂H₂₆O₅
• 分子量: 370.445
• InChiKey: NXQTVWZUIUBMTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  52.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲氧基苄醇 、 环氧溴丙烷 以 四氢呋喃 为溶剂， 生成 2,3-epoxypropyl-4-methoxybenzyl ether
  参考文献：
  名称：

  Substituted alkylidene imidazoles

  摘要：

  这项披露涉及一类新型的取代烷基亚胺唑衍生物及其药用盐。该披露进一步描述了含有这种化合物的药物组合物，并描述了将这些化合物和组合物用作选择性抑制酶血栓素合酶活性的药剂的用途。

  公开号：

  US04837333A1

文献信息

• Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having
  申请人：G. D. Searle & Co.

  公开号：US04579862A1

  公开（公告）日：1986-04-01

  Compounds of the general formula ##STR1## and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]he xanoic acid.

  通式为##STR1##的化合物及其药用盐具有抗血栓活性。Het代表1-[1H-咪唑基]，1-N-吗啉基或吡啶基。代表性化合物是6-[2-(1H-咪唑-1-基)-1-基-1-[[(4-甲氧基苯基)甲氧基]甲基]乙氧基]己酸。
• Imidazole derivatives used in antithrombotic method
  申请人：G. D. Searle & Co.

  公开号：US04567189A1

  公开（公告）日：1986-01-28

  Compounds of the general formula: ##STR1## and acid addition salts thereof; in which Ar and Ar.sup.1 which may be the same or different, each represent an aromatic radical which may be substituted one or more times by substituents selected from the following: halogen; lower alkyl; lower alkoxy; alkylenedioxy; aralkoxy; aryloxy; trihalomethyl; carboxy; carboxyalkyl; cyano; carboxamido; di-lower alkylamino; nitro; and lower alkyl sulphonyl provided that one of the groups Ar and Ar.sup.1 carries at least one alkoxy, alkylenedioxy, carboxy or carboxyalkyl substituent; and Alk.sup.1 and Alk.sup.2, which may be the same or different, each represent an alkylene group containing from 1 to 8 carbon atoms which may be substituted one or more times by lower alkyl; X and Y which may be the same or different represent oxygen, nitrogen or sulphur; and in which the imidazole ring may be substituted by one or more lower alkyl substituents have antithrombotic activitiy. A representative compound is 1-[2-[(4-methoxyphenyl)methoxy]-3-[(4-methoxyphenyl)methoxy]propyl]-1H-imi dazole.

  通式为：##STR1##的化合物及其酸盐；其中Ar和Ar.sup.1可能相同也可能不同，每个代表一个芳香基团，可以被以下取代基取代一次或多次：卤素；低烷基；低烷氧基；烷二氧基；芳基氧基；三卤甲基；羧基；羧基烷基；氰基；羧酰胺基；二低烷胺基；硝基；和低烷基磺酰基，前提是Ar和Ar.sup.1中的一个至少携带一个烷氧基、烷二氧基、羧基或羧基烷基取代基；Alk.sup.1和Alk.sup.2，可能相同也可能不同，每个代表含有1至8个碳原子的烷基基团，可以被低烷基取代一次或多次；X和Y可能相同也可能不同，代表氧、氮或硫；咪唑环可能被一次或多次低烷基取代基取代，具有抗血栓活性。代表性化合物是1-[2-[(4-甲氧基苯基)甲氧基]-3-[(4-甲氧基苯基)甲氧基]丙基]-1H-咪唑。
• Imidazole derivatives
  申请人：G.D. Searle & Co.

  公开号：EP0062918A2

  公开（公告）日：1982-10-20

  Compounds of the general formula: and acid addition salts thereof; in which Ar and Ar1 which may be the same or different, each represent an aromatic radical which may be substituted one or more times by substituents selected from the following: provided that one of the groups Ar and Ar1 carries at least one alkoxy, alkylenedioxy, carboxy or carboxyalkyl substituent; and Alk1 and Alk2, which may be the same or different, each represent an alkylene group containing from 1 to 8 carbon atoms which may be substituted one or more times by lower alkyl; X and Y which may be the same or different represent oxygen, nitrogen or sulphur; and in which the imidazole ring may be substituted by one or more lower alkyl substituents have antithrombotic activity. A representative compound is 1-(2-((4-methoxyphenyl)methoxy]-3-((4-methoxyphenyl)methoxypropyl]-1 H-imidazole.

  通式如下的化合物及其酸加成盐 及其酸加成盐；其中 Ar 和 Ar1 可以相同或不同，各自代表一个芳香基，该芳香基可被选自以下的取代基一次或多次取代： 条件是 Ar 和 Ar1 基团之一带有至少一个烷氧基、烷二氧基、羧基或羧烷基取代基；以及 Alk1 和 Alk2（可以相同或不同）分别代表含有 1 至 8 个碳原子的亚烷基，可被低级烷基取代一次或多次； 可相同或不同的 X 和 Y 代表氧、氮或硫；其中咪唑环可被一个或多个低级烷基取代基取代 具有抗血栓活性。具有代表性的化合物是 1-(2-((4-甲氧基苯基)甲氧基]-3-((4-甲氧基苯基)甲氧基丙基]-1 H-咪唑。
• 1-(1H-imidazolyl), 1-N-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them
  申请人：G.D. Searle & Co.

  公开号：EP0105575A1

  公开（公告）日：1984-04-18

  Compounds of the general formula and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-([(4-methoxyphenyl)methoxy]-methyl]ethoxy]hexanoic acid.

  通式为 及其药学上可接受的盐类具有抗血栓活性。Het 代表 1-[1H-咪唑基]、1-N-吗啉基或吡啶基。具有代表性的化合物是 6-[2-(1H-咪唑-1-基)-1-基-1-([(4-甲氧基苯基)甲氧基]-甲基]乙氧基]己酸。
• US4567189A
  申请人：——

  公开号：US4567189A

  公开（公告）日：1986-01-28