The present invention relates to a compound of the formula:
wherein R1 is hydrogen or a lower alkyl; R2 is methyl which is substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group or C2-15 chain-like hydrocarbon residue having no lower alkyl at the a-position which may be substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group; R3 is a lower alkyl; R4 is hydrogen or acyl; and R5 and R6 each is a lower alkyl or lower alkoxy, or R5 and R6 combinedly are butadienylene or a salt thereof.
The compound (I) of the present invention has a strong 5- and 12-lipoxygenase inhibiting action, is of high safety and is useful as, among others, an agent for ameliorating circulatory system, an anti-allergic agent and a pharmaceutical agent for central nervous system
本发明涉及一种式化合物:
其中 R1 是氢或低级烷基;R2 是被羧基、烷氧羰基、
氰基、卤素、芳基或杂环基取代的甲基或在 a 位没有低级烷基的 C2-15 链状烃残基,该残基可被羧基、烷氧羰基、
氰基、卤素、芳基或杂环基取代;R3 是低级烷基;R4 是氢或酰基;R5 和 R6 各自是低级烷基或低级烷氧基,或 R5 和 R6 合在一起是
丁二烯或其盐。
本发明的化合物(I)具有很强的 5-和 12-脂氧合酶抑制作用,安全性高,可用作改善循环系统的药物、抗过敏药物和治疗中枢神经系统的药物等。