tert-butyl(2-iodoethoxy)diphenylsilane | 126822-71-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl(2-iodoethoxy)diphenylsilane
• 英文别名: 1-iodo-2-tert-butyldiphenylsilyloxy ethane；tert-butyl-(2-iodoethoxy)-diphenylsilane
• CAS: 126822-71-7
• 化学式: C₁₈H₂₃IOSi
• 分子量: 410.37
• InChiKey: XRGRXPFJGNTEAB-UHFFFAOYSA-N

物化性质

• 沸点：
  383.2±34.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.0
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  tert-butyl(2-iodoethoxy)diphenylsilane 在 lithium aluminium tetrahydride 、 lipase AK from Pseudomonas fluorescens 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醚 、 异丙醚 、 mineral oil 为溶剂， 反应 13.5h， 生成 (R)-4-(tert-butyldiphenylsilyloxy)-2-(hydroxymethyl)butyl acetate
  参考文献：
  名称：

  Asymmetric total synthesis of (−)-rasfonin

  摘要：

  An efficient chemoenzymatic asymmetric synthesis of pyranone containing natural product (-)-rasfonin is presented here. Enantioselective enzymatic desymmetrization (EED) and a unique Gluconobacter oxydans mediated oxidative kinetic resolution (OKR) have been successfully employed to install three stereocenters (C-6', C-7, and C-9) of the target molecule. Stereoselective Achmatowicz reaction of a properly decorated furyl nucleus led to the core pyranone structure of rasfonin. At the late stage of the synthesis Negishi coupling has been used to complete the synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.051
• 作为产物：
  描述：

  叔丁基二苯基氯硅烷 在 咪唑 、 碘 、 sodium hydride 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl(2-iodoethoxy)diphenylsilane
  参考文献：
  名称：

  The furan approach to oxacycles: synthesis of medium-size 2,3-disubstituted oxacycles

  摘要：

  We describe an efficient new approach for the synthesis of medium-size oxacycles that is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular Michael addition. This present study enlarges the scope of the furan approach strategy for the synthesis of oxepanes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.035

文献信息

• The asymmetric synthesis of α-substituted α-methyl and α-phenyl phosphonic acids: Design, carbanion geometry, reactivity and preparative aspects of chiral alkyl bicyclic phosphonamides
  作者：Youssef L. Bennani、Stephen Hanessian

  DOI：10.1016/0040-4020(96)00829-0

  日期：1996.10

  The design, preparation, structural and spectroscopic analyses of topologically unique and enantiomerically pure alkyl phosphonamides are described. In the case of α-ethyl and α-benzyl phosphonamides, the geometry of both the secondary and tertiary carbanions was determined to be planar through deprotonation/deuteration/alkylation experiments. Stereoselective alkylations of such systems proceeded in

  描述了拓扑独特和对映体纯的烷基膦酰胺的设计，制备，结构和光谱分析。在α-乙基和α-苄基膦酰胺的情况下，通过去质子化/氘代/烷基化实验，确定了仲和叔碳负离子的几何形状均为平面。这种系统的立体选择性烷基化以高收率和高非对映选择性进行。水解所得的α，α-烷基膦酰胺，得到具有高对映体纯度的相应的α，α-烷基膦酸。
• Concise Synthesis of the<i>Erythrina</i>Alkaloid 3-Demethoxyerythratidinone via Combined Rhodium Catalysis
  作者：Jung Min Joo、Ramoncito A. David、Yu Yuan、Chulbom Lee

  DOI：10.1021/ol102535u

  日期：2010.12.17

  The total synthesis of the erythrina alkaloid 3-demethoxyerythratidinone has been achieved via a strategy based on combined rhodium catalysis. The catalytic tandem cyclization effected by the interplay of alkynyl and vinylidene rhodium species allows for efficient access to the A and B rings of the tetracyclic erythrinane skeleton in a single step. The synthesis also features rapid preparation of the

  通过基于联合铑催化的策略，已经实现了赤藓类生物碱 3-脱甲氧基赤藓酮酮的全合成。由炔基和亚乙烯基铑物种相互作用实现的催化串联环化允许在一个步骤中有效地进入四环赤藓烷骨架的 A 和 B 环。该合成还具有快速制备双环闭合所需前体的特点，因此仅在 7 个总步骤中完成，总产率为 41%。
• Preparation of C-4 Alkylated Dideoxyribosides: Potential Precursors to a Novel Series of Nucleosides
  作者：Bruce H. Lipshutz、Sunaina Sharma、Stuart H. Dimock、James R. Behling

  DOI：10.1055/s-1992-34158

  日期：——

  Methallyl alcohol can be converted in five simple operations (alkylation, epoxidation, alkynyl-coupling, hydroboration/oxidation, cyclization) to C-5 protected, chiral, non-racemic dideoxyribosides containing an alkyl appendage at the C-4 site.

  甲基烯丙醇通过五个简单的步骤（烷基化、环氧化、炔基偶联、氢硼化/氧化、环合反应）可以转化为在C-4位带有烷基侧链的C-5保护、手性、非外消旋的双脱氧核苷。
• Furan derivatives, method of synthesis and uses thereof
  申请人：Neuropharma S.A.

  公开号：EP1939191A1

  公开（公告）日：2008-07-02

  The present invention relates to furan derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

  本发明涉及式(I)的呋喃衍生物，其合成方法及用途。具体来说，所披露的化合物已被证明是糖原合成酶激酶3β（GSK-3β）的抑制剂，GSK-3β已知参与不同疾病和病况，如阿尔茨海默病或非胰岛素依赖型糖尿病。本发明还涉及包含这些化合物的药物组合物。此外，本发明旨在将这些化合物用于制造治疗和/或预防GSK-3介导的疾病或病况的药物。
• RAS INHIBITORS
  申请人：Revolution Medicines, Inc.

  公开号：US20210130326A1

  公开（公告）日：2021-05-06

  The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

  该披露涉及大环化合物，以及能够抑制Ras蛋白质的药物组合物和蛋白质复合物，以及它们在治疗癌症中的用途。