3-(9H-Xanthen-9-YL)propan-1-OL | 648928-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-(9H-Xanthen-9-YL)propan-1-OL
• CAS: 648928-44-3
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: LLJPQOXIZDQLIP-UHFFFAOYSA-N

物化性质

• 沸点：
  365.1±21.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(9H-Xanthen-9-YL)propan-1-OL 在 sodium tetrahydroborate 、 戴斯-马丁氧化剂 、 三乙胺 作用下， 以 甲醇 为溶剂， 生成 N-丁基-N-[3-(9H-黄嘌呤-9-基)丙基]氨基甲酸乙酯
  参考文献：
  名称：

  氨基甲酸酯的阴离子环酰化反应合成螺[吡咯烷或哌啶-3,9'-黄嘌呤]

  摘要：

  an吨螺吡咯烷和螺哌啶是通过以下方法合成的，其中关键步骤是通过位于相同位置的氨基甲酸酯侧链将黄原9-基阴离子分子内捕获。

  DOI：

  10.1016/j.tetlet.2003.10.065
• 作为产物：
  描述：

  (9H-氧杂蒽-9-基)-乙酸 在 lithium aluminium tetrahydride 、 氯化亚砜 、 silver benzoate 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 苯 为溶剂， 生成 3-(9H-Xanthen-9-YL)propan-1-OL
  参考文献：
  名称：

  Design, synthesis and preliminary evaluation of novel 3′-Substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors

  摘要：

  Two novel 3'-substituted carboxycylopropylglycines, (2S,1'S,2'S,3'R)-2-(3'- xanthenylmethyl-2'-carboxycyclopropyl)glycine (8a) and (2S,1'S,2'S,3'R)-2-(3'-xanthenylethyl-2'-carboxycyclopropyl)glycine (8b), were synthesized and evaluated as mGluR ligands. Compound 8b showed to be a potent group II antagonist with submicromolar activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00656-4

文献信息

• Conditioning detergent compositions
  申请人：LiBrizzi J. Joseph

  公开号：US20050019299A1

  公开（公告）日：2005-01-27

  A conditioning detergent composition comprised of a surfactant portion comprising at least one of anionic, amphoteric, and nonionic surfactants and a conditioner portion comprising at least one branched cationic polymers and a silicone which is different from said branched cationic polymer and which is matrix soluble. The conditioning detergent composition imparts cleansing, wet detangling, dry detangling and manageability to hair and which is relatively non-irritating and thus suitable for use by young children and adults having sensitive skin and eyes. The conditioning detergent composition is able to provide such benefits in an aesthetically pleasing formulation without the need for suspending agents, opacifiers, or pearlizing agents.

  一种护理洗涤剂组合物，由表面活性剂部分和护理剂部分组成，表面活性剂部分包括阴离子、两性离子和非离子表面活性剂中的至少一种，护理剂部分包括至少一种支链阳离子聚合物和一种不同于上述支链阳离子聚合物且可溶于基质的硅氧烷。这种护发洗涤剂组合物具有清洁、湿发顺发、干发顺发和头发易打理的功效，而且相对无刺激性，因此适合皮肤和眼睛敏感的幼儿和成人使用。这种护理洗涤剂组合物无需使用悬浮剂、不透明剂或珠光剂，就能以美观的配方提供上述优点。
• Synthesis of spiro[pyrrolidine or piperidine-3,9′-xanthenes] by anionic cycloacylation of carbamates
  作者：Domingo Quintás、Alberto Garcı́a、Domingo Domı́nguez

  DOI：10.1016/j.tetlet.2003.10.065

  日期：2003.12

  Xanthene spiropyrrolidines and spiropiperidines were synthesized by a process in which the key step was intramolecular trapping of a xanthen-9-yl anion by a carbamate side-chain situated at the same position.

  an吨螺吡咯烷和螺哌啶是通过以下方法合成的，其中关键步骤是通过位于相同位置的氨基甲酸酯侧链将黄原9-基阴离子分子内捕获。
• Design, synthesis and preliminary evaluation of novel 3′-Substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors
  作者：Roberto Pellicciari、Gabriele Costantino、Maura Marinozzi、Antonio Macchiarulo、Laura Amori、Peter Josef Flor、Fabrizio Gasparini、Rainer Kuhn、Stephan Urwyler

  DOI：10.1016/s0960-894x(01)00656-4

  日期：2001.12

  Two novel 3'-substituted carboxycylopropylglycines, (2S,1'S,2'S,3'R)-2-(3'- xanthenylmethyl-2'-carboxycyclopropyl)glycine (8a) and (2S,1'S,2'S,3'R)-2-(3'-xanthenylethyl-2'-carboxycyclopropyl)glycine (8b), were synthesized and evaluated as mGluR ligands. Compound 8b showed to be a potent group II antagonist with submicromolar activity. (C) 2001 Elsevier Science Ltd. All rights reserved.