5,5'-dichloro-2,2'-dimethoxy-biphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5'-dichloro-2,2'-dimethoxy-biphenyl
• 英文别名: 5,5'-dichloro-2,2'-dimethoxybiphenyl；5,5'-Dichlor-2,2'-dimethoxy-biphenyl；4-chloro-2-(5-chloro-2-methoxyphenyl)-1-methoxybenzene
• 化学式: C₁₄H₁₂Cl₂O₂
• 分子量: 283.154
• InChiKey: XDBYLBIYPIXAAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯苯甲醚 在 chloroauric acid 碘苯二乙酸 作用下， 以 溶剂黄146 为溶剂， 反应 17.0h， 以68%的产率得到5,5'-dichloro-2,2'-dimethoxy-biphenyl
  参考文献：
  名称：

  非活化芳烃的一般金催化的直接氧化偶联。

  摘要：

  描述了使用PhI（OAc）2作为氧化剂的芳烃金催化的轻度和一般氧化均质偶联（13个实例，收率31-81％）。

  DOI：

  10.1039/b714928j

文献信息

• Gold-catalyzed direct oxidative coupling reactions of non-activated arenes
  作者：Anirban Kar、Naveenkumar Mangu、Hanns Martin Kaiser、Man Kin Tse

  DOI：10.1016/j.jorganchem.2008.11.016

  日期：2009.2

  A general gold-catalyzed oxidative homo- and hetero-coupling of arenes in mild conditions is described. This reaction gives moderate to excellent yield using PhI(OAc)2 as an oxidant. The effects of temperature, solvent, oxidant and concentration of substrate in this process have also been studied in detail. The product identity and distribution as well as the substrate limitation give us insights into

  描述了在温和条件下一般的金催化的芳烃的氧化均质和异质偶联。使用PhI（OAc）2作为氧化剂，该反应可获得中等至极好的收率。还详细研究了温度，溶剂，氧化剂和底物浓度在此过程中的影响。产品的特性和分布以及底物的限制使我们对这种类型的金催化剂有了更深入的了解。取决于反应条件，金催化剂表现为简单的路易斯酸，其使用DIAD作为胺化试剂从芳烃中生成胺。
• Verfahren zur Herstellung von Hydrogelen in Form kugelförmiger Perlen grösseren Durchmessers
  申请人：CIBA-GEIGY AG

  公开号：EP0000507A1

  公开（公告）日：1979-02-07

  Die vorliegende Erfindung betrifft ein verbessertes Verfahren zur Herstellung einheitlicher, kugelförmiger Perlen mit einem Durchmesser bis zu 5 mm, weiche aus einem vernetzten, wasserunlöslichen Hydrogel bestehen. Hydrogele dieser Art werden mittels suspendierter Polymerisation in konzentrierten Lösungen eines Salzes, in denen monoolefinische Monomere und endständig diolefinische Macromere enthalten sind, in Gegenwart eines wasserunlöslichen, gallertartigen, stark wasserbindenden anorganischen Metallhydroxids als Suspensionsmittel in Abwesenheit von überschüssigem Alkali hergestellt. Hydrogele dieser Art können in vielfacher Weise für pharmazeutische und industrielle Zwecke verwendet werden.

  本发明涉及一种改良工艺，用于生产直径不超过 5 毫米的均匀球形珠子，这种珠子由交联的不溶于水的水凝胶组成。这种水凝胶的制备方法是：在不含过量碱的情况下，在含有单烯烃单体和末端二烯烃大分子的盐的浓溶液中，以不溶于水、胶状、强水结合的无机金属氢氧化物为悬浮剂，进行悬浮聚合。这种类型的水凝胶可用于多种制药和工业用途。
• Inhibition of Enterococcus faecalis biofilm formation by highly active lactones and lactams analogues of rubrolides
  作者：Ulisses A. Pereira、Luiz C.A. Barbosa、Célia R.A. Maltha、Antônio J. Demuner、Mohammed A. Masood、Andréa L. Pimenta

  DOI：10.1016/j.ejmech.2014.05.035

  日期：2014.7

  Seven beta-aryl substituted gamma-alkylidene-gamma-lactones analogues of rubrolides were synthesized from mucobromic acid and converted through a lactamization with isobutylamine into their corresponding gamma-hydroxy-gamma-lactams (76-85%). These lactams were converted into (Z)- and (E)-gamma-alkylidene-gamma-lactams (23 -45%). All compounds were fully characterized by IR, NMR (H-1 and C-13), COSY and HETCOR bidimensional experiments, and NOE difference spectroscopy experiments when necessary. Evaluation of these three different classes of compounds against Enterococcus faecalis biofilm formation showed that all classes are active and the highest biofilm inhibition activity was caused by lactam 13f (IC50 = 0.76 mu g/mL). Moreover, in almost all cases at least one of the lactams is more active than its correspondent gamma-alkylidene-gamma-lactone. The use of rubrolides as a lead structure has proven successful for the identification of new compounds displaying novel antibacterial activities, namely biofilm inhibition, which have the potential for the development of antimicrobial drugs targeted to inhibition of the initial stages of bacterial infections, rather than bacterial viability. Such drugs are less prompt to induce bacterial resistance, being therefore a more cost-effective investment for pharmaceutical research. (C) 2014 Elsevier Masson SAS. All rights reserved.
• STEREOCHEMISTRY OF DIPHENYLS.¹ XXVI. THE EFFECT OF SUBSTITUTION ON THE RATE OF RACEMIZATION OF CERTAIN OPTICALLY ACTIVE DIPHENYLS
  作者：H. C. Yuan、Roger Adams

  DOI：10.1021/ja01350a047

  日期：1932.11
• Aver'yanov, S. F.; Rudenko, A. P., Russian Journal of Organic Chemistry, 1995, vol. 31, # 8, p. 1089 - 1098
  作者：Aver'yanov, S. F.、Rudenko, A. P.

  DOI：——

  日期：——