2-(2-hydroxyethyl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione | 77967-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2-hydroxyethyl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione
• 英文别名: 2-(2-hydroxyethyl)-4,5,6,7-tetrahydroisoindole-1,3-dione
• CAS: 77967-47-6
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: RJZLGFKMSYCZDD-UHFFFAOYSA-N

物化性质

• 熔点：
  50-52 °C
• 沸点：
  382.5±25.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxyethyl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-[2-[[(diphenyl)(2-propenyloxy)silyl]oxy]ethyl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione
  参考文献：
  名称：

  四氢邻苯二甲酰亚胺衍生物的分子内[2 + 2]光环加成反应中的临时束缚的使用：一种复杂的三环内酯的新方法。

  摘要：

  一系列与醇胺，1-（+）-缬氨酸和R -（-）-2-苯基甘氨醇束缚的烯醇通过碳酸盐或硅形成的分子内[2 + 2]光环加成反应链接已被检查。这些[2 + 2]光环加成反应可在所有情况下以完全的内位控制和高非对映选择性（手性系链高达8：1）高产率提供相应的环丁烷。通过去甲硅烷基化或水解来裂解临时系链提供了内二醇。通过还原/水解裂解乙醇胺键沉淀了酸催化的断裂/环扩展序列，以生成复杂的三环内酯。

  DOI：

  10.1016/j.tet.2007.02.064
• 作为产物：
  描述：

  3,4,5,6-四氢苯酐 、 C.I.酸性橙108 以 甲苯 为溶剂， 反应 3.0h， 以98%的产率得到2-(2-hydroxyethyl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione
  参考文献：
  名称：

  四氢邻苯二甲酰亚胺衍生物的分子内[2 + 2]光环加成反应中的临时束缚的使用：一种复杂的三环内酯的新方法。

  摘要：

  一系列与醇胺，1-（+）-缬氨酸和R -（-）-2-苯基甘氨醇束缚的烯醇通过碳酸盐或硅形成的分子内[2 + 2]光环加成反应链接已被检查。这些[2 + 2]光环加成反应可在所有情况下以完全的内位控制和高非对映选择性（手性系链高达8：1）高产率提供相应的环丁烷。通过去甲硅烷基化或水解来裂解临时系链提供了内二醇。通过还原/水解裂解乙醇胺键沉淀了酸催化的断裂/环扩展序列，以生成复杂的三环内酯。

  DOI：

  10.1016/j.tet.2007.02.064

文献信息

• Diastereoselective intramolecular photochemical [2 + 2] cycloaddition reactions of tethered l-(+)-valinol derived tetrahydrophthalimides
  作者：Kevin I. Booker-Milburn、Sirin Gulten、Andrew Sharpe

  DOI：10.1039/a702386c

  日期：——

  Intramolecular photochemical [2 + 2] cycloaddition of allyl alcohol linked to amino acid derived 3,4,5,6-tetrahydrophthalimides, either via a carbonate or silicon tether, gives the corresponding cyclobutanes in excellent yield with diastereoselectivities as high as 8:1.

  丙烯醇与氨基酸衍生的3,4,5,6-四氢邻苯二甲酰亚胺通过碳酸酯或硅连接的分子内光化学[2 + 2]环加成，优异产率下生成相应的环丁烷，非对映选择性高达8:1。
• Gel particles, photosensitive composition, ink composition, method of producing water dispersion of gel particles, and image forming method
  申请人：FUJIFILM CORPORATION

  公开号：US10358568B2

  公开（公告）日：2019-07-23

  Provided are gel particles each having a three-dimensional crosslinked structure having at least one bond selected from a urethane bond and a urea bond, the gel particles each including: a maleimide group represented by Formula 1 below, a photosensitive composition, an ink composition, a method of producing water dispersion of gel particles, and an image forming method. In Formula 1, R1 and R2 each independently represent a hydrogen atom or an alkyl group, R1 and R2 may be bonded to each other to form a ring, and * represents a bonding site.

  本发明提供了具有三维交联结构的凝胶微粒，每种凝胶微粒都具有至少一个选自聚氨酯键和脲键的键，每种凝胶微粒都包括：由下式 1 表示的马来酰亚胺基团、感光组合物、油墨组合物、凝胶微粒水分散体的生产方法以及图像形成方法。在式 1 中，R1 和 R2 各自独立地代表氢原子或烷基，R1 和 R2 可以相互键合形成环，* 代表键合部位。
• Active energy radiation hardenable skin plaster composition and skin plaster
  申请人：Ito Kenji

  公开号：US20070004896A1

  公开（公告）日：2007-01-04

  [Problems] A composition curable with active energy beams for use in skin patches is provided, which is liquid at ordinary temperature, has a practical crosslinking property or curability in the absence of photopolymerization initiators even when irradiated with visible or ultraviolet light, and provides cured films that are not discolored and excellent in various pressure-sensitive adhesive performances and have appropriate pressure-sensitive adhesiveness so as not to cause pain or damage to the horny layer in the patch-applied area even when patches are repeatedly applied and peeled off, as well as excellent water resistance. [Means for solving problems] The composition curable with active energy beams for use in skin patches is liquid at ordinary temperature and comprises (A) a compound having two or more maleimide groups and (B) an oil component, or water or a water-soluble compound.
• Photoradical polymerization initiator, radical generator, photosensitive compound and photosensitive resin composition containing these materials and product or its accessory portions using the composition
  申请人：SAKAYORI Katsuya

  公开号：US20080275154A1

  公开（公告）日：2008-11-06

  The present invention provides a radical generator having a naphthalimide structure or a crosslinking agent and a photosensitive compound having a function as a radical generator. A photoradical polymerization initiator of the present invention comprises a compound (a) having only one naphthalimide structure-containing group in one molecule. The radial generator of the present invention comprises a compound (c) having two or more naphthalimide structure-containing groups in one molecule and also functions as a crosslinking agent. A first photosensitive compound of the present invention comprises a compound (d) having a naphthalimide structure-containing group and an ethylenic unsaturated group in one molecule. A second photosensitive compound of the present invention comprises a polymer (e) of one or more radical polymerizable compounds containing the compound (d). A photosensitive resin composition according to the present invention contains, as an essential component, the above compound (a), compound (c), compound (d) or polymer (e).
• GEL PARTICLES, PHOTOSENSITIVE COMPOSITION, INK COMPOSITION, METHOD OF PRODUCING WATER DISPERSION OF GEL PARTICLES, AND IMAGE FORMING METHOD
  申请人：FUJIFILM CORPORATION

  公开号：US20170166766A1

  公开（公告）日：2017-06-15

  Provided are gel particles each having a three-dimensional crosslinked structure having at least one bond selected from a urethane bond and a urea bond, the gel particles each including: a maleimide group represented by Formula 1 below, a photosensitive composition, an ink composition, a method of producing water dispersion of gel particles, and an image forming method. In Formula 1, R 1 and R 2 each independently represent a hydrogen atom or an alkyl group, R 1 and R 2 may be bonded to each other to form a ring, and * represents a bonding site.