2-氯-N,N-二乙基-2-苯乙酰胺 | 65117-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-N,N-二乙基-2-苯乙酰胺
• 英文名称: 2-chloro-N,N-diethyl-2-phenylacetamide
• 英文别名: NN-diethyl-2-chlorophenylacetamide；(+/-)-chloro-phenyl-acetic acid diethylamide；(+/-)-Chlor-phenyl-essigsaeure-diaethylamid；2-chloro-N,N-diethyl-2-phenyl-acetamide；α-Chlor-phenylessigsaeure-diethylamid；N,N-Diethyl-α-chlor-phenylacetamid
• CAS: 65117-31-9
• 化学式: C₁₂H₁₆ClNO
• mdl: MFCD00544109
• 分子量: 225.718
• InChiKey: XGCSCGPEXJYFRH-UHFFFAOYSA-N

物化性质

• 熔点：
  50-51 °C
• 沸点：
  129-133 °C(Press: 0.5 Torr)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-氯-N,N-二乙基-2-苯乙酰胺 在 sodium disulfide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以5%的产率得到NNN'N'-tetraethyl-2,2'-dithiodiphenylacetamide
  参考文献：
  名称：

  Aoyama, Hiromu; Suzuki, Shin-ichi; Hasegawa, Tadashi, Journal of the Chemical Society. Perkin transactions I, 1982, p. 247 - 248

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-dichloro-2-phenylacetyl chloride 在 三丁基膦 、 水 作用下， 以 苯 为溶剂， 生成 2-氯-N,N-二乙基-2-苯乙酰胺
  参考文献：
  名称：

  Reaction of Phosphorus Compounds. IV. Haloenamines and Imidoyl Chlorides from Reaction of Phosphines with Haloamides

  摘要：

  DOI：

  10.1021/ja00869a021

文献信息

• SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
  申请人：Bonaventure Pascal

  公开号：US20070100141A1

  公开（公告）日：2007-05-03

  The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.

  这项发明提供了新型的非肽类NPY Y2受体抑制剂，可用于治疗或预防：抗焦虑障碍或抑郁症；受损的哺乳动物神经组织；通过给予神经营养因子进行治疗的疾病；神经系统疾病；骨质流失；与物质相关的障碍；睡眠/清醒障碍；心血管疾病；肥胖症；或与肥胖相关的疾病。该发明的化合物还可用于调节内分泌功能，特别是垂体和下丘脑腺控制的内分泌功能，并因此可用于治疗或预防排卵障碍和不孕症。
• Synthesis of Aliphatic (E)-α,β-Unsaturated Amides with High Diastereoselectivity fromα,β-Epoxyamides Promoted by SmI2/HMPA
  作者：José M. Concellón、Eva Bardales

  DOI：10.1002/ejoc.200300641

  日期：2004.4

  Synthesis of aliphatic (E)-α,β-unsaturated amides 2, in which the C=C bond is di- or trisubstituted, is achieved by using samarium diiodide and HMPA. The starting compounds 1 were easily prepared by the reaction of the corresponding lithium or potassium enolates of α-chloroamides with aldehydes. A mechanism to explain this process is proposed. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany

  通过使用二碘化钐和 HMPA 合成脂肪族 (E)-α,β-不饱和酰胺 2，其中 C=C 键被二或三取代。起始化合物 1 很容易通过相应的 α-氯酰胺的烯醇锂或烯醇钾与醛反应来制备。提出了一种解释这一过程的机制。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
• Epoxysilane Rearrangement Induced by a Carbanion Generated by Conjugate Addition of Enolates of Chloroacetate and α-Chloroacetamides:  Formation of Functionalized Cyclopropane Derivatives
  作者：Noriko Okamoto、Michiko Sasaki、Masatoshi Kawahata、Kentaro Yamaguchi、Kei Takeda

  DOI：10.1021/ol060469k

  日期：2006.4.1

  moiety at the alpha-position with lithium enolate of 2-chloroacetamide afforded highly functionalized cyclopropane derivatives via a tandem process that involves Michael addition, ring opening of the epoxide, Brook rearrangement, and intramolecular alkylation.

  [反应：参见正文]通过串联反应，包括迈克尔加成，环氧化物的开环，布鲁克重排和分子内烷基化。
• [EN] PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR<br/>[FR] DÉRIVÉS PIPÉRAZINYLE UTILES COMME MODULATEURS DU RÉCEPTEUR DU NEUROPEPTIDE Y2
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009079593A1

  公开（公告）日：2009-06-25

  The present invention is directed to piperidinyl and piperazinyl derivatives of formula (I) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and / or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

  本发明涉及式（I）的哌啶基和哌嗪基衍生物，其作为NPY Y2受体的抑制剂，包含该化合物的药物组合物，制备该化合物的过程以及利用该化合物治疗和/或预防由NPY Y2受体介导的疾病、疾病和病况。
• Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor
  申请人：Janssen Pharmaceutica NV

  公开号：US08183239B2

  公开（公告）日：2012-05-22

  The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility. The compounds of the present invention are of the formula where Ring T is a heterocycloalkyl ring selected from the group consisting of:

  该发明提供了一种新型的非肽类NPY Y2受体抑制剂，可用于治疗或预防：抗焦虑障碍或抑郁症；受损哺乳动物神经组织；通过神经营养因子的给药治疗反应性疾病；神经系统疾病；骨质流失；与物质相关的疾病；睡眠/清醒障碍；心血管疾病；肥胖症；或肥胖相关疾病。本发明的化合物还可用于调节内分泌功能，尤其是垂体和下丘脑腺体控制的内分泌功能，并因此可用于治疗或预防无排卵和不孕症。本发明的化合物的结构式如下：其中Ring T是从以下群组中选择的杂环烷基环：