3-(methylthio)-4-nitroveratrole | 30058-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(methylthio)-4-nitroveratrole
• 英文别名: methyl 4,5-dimethoxy-2-nitrophenyl sulfide；(4,5-dimethoxy-2-nitrophenyl)(methyl)sulfane；3-Methylthio-4-nitroveratrol；1,2-dimethoxy-4-methylsulfanyl-5-nitrobenzene
• CAS: 30058-45-8
• 化学式: C₉H₁₁NO₄S
• 分子量: 229.257
• InChiKey: GUVWCCLWWZOVNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  89.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(methylthio)-4-nitroveratrole 在 盐酸 、 tin 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-Diethylamino-ethyl)-N-(4,5-dimethoxy-2-methylsulfanyl-phenyl)-N',N'-diethyl-ethane-1,2-diamine
  参考文献：
  名称：

  抗疟疾2-溴-N，N-双（二乙基氨基乙基）-4,5-二甲氧基苯胺的类似物。2位置变化。

  摘要：

  DOI：

  10.1021/jm00300a021
• 作为产物：
  描述：

  甲硫醇 、 4-溴-5-硝基藜芦醚 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以78.6%的产率得到3-(methylthio)-4-nitroveratrole
  参考文献：
  名称：

  Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadiazine 1-oxide derivatives

  摘要：

  A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piperazinyl]-6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine 1-oxide hydrochloride. This compound in animal tests was equipotent to the known antihypertensive Prazosin.

  DOI：

  10.1021/jm00181a003

文献信息

• Palladium-Catalyzed Decarboxylative Methylthiolation of Aromatic Carboxylic Acids by Using DMSO as the Sulfurizing Reagent
  作者：Zhengjiang Fu、Zhaojie Li、Qiheng Xiong、Hu Cai

  DOI：10.1002/ejoc.201403147

  日期：2014.12

  By using simple and readily available DMSO as a convenient and environmentally friendly source of sulfur, a practical approach for the Pd-catalyzed decarboxylative methylthiolation of 2-nitrobenzoic acids was developed. A range of substituents on the aryl group of the ortho-nitrobenzoic acid were compatible with this process.

  通过使用简单易得的 DMSO 作为一种方便且环保的硫源，开发了一种用于 Pd 催化的 2-硝基苯甲酸脱羧甲硫基化的实用方法。邻硝基苯甲酸的芳基上的一系列取代基与该过程相容。
• Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO
  作者：Liang Hu、Dadian Wang、Xiang Chen、Lin Yu、Yongqi Yu、Ze Tan、Gangguo Zhu

  DOI：10.1039/c7ob01315a

  日期：——

  A novel copper-catalyzed decarboxylative methylthiolation of arenecarboxylate salts has been realized using DMSO as the methylthiolation source. Various potassium aryl carboxylates underwent decarboxylative methylthiolation under air to furnish the corresponding aryl methyl thioethers in moderate to excellent yields. The reaction tolerated a wide variety of functional groups. Notably, the synthesis

  使用DMSO作为甲基硫醇化来源，已经实现了芳族羧酸盐的新型铜催化的脱羧甲基硫醇化。各种芳基羧酸钾在空气中进行了脱羧甲基硫醇化反应，以中等至优异的产率提供了相应的芳基甲基硫醚。该反应可耐受多种官能团。值得注意的是，在相似的反应条件下，也可以直接由二乙基亚砜直接成功地完成乙基硫醚的合成。
• DILLARD R. D.; YEN T. T.; STARK P.; PAVEY D. E., J. MED. CHEM., 1980, 23, NO 7, 717-722
  作者：DILLARD R. D.、 YEN T. T.、 STARK P.、 PAVEY D. E.

  DOI：——

  日期：——
• Analogs of the antimalarial 2-bromo-N,N-bis(diethylaminoethyl)-4,5-dimethoxyaniline. 2-Position variations
  作者：Eugene L. Stogryn

  DOI：10.1021/jm00300a021

  日期：1970.11
• Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadiazine 1-oxide derivatives
  作者：Robert D. Dillard、Terence T. Yen、Paul Stark、Donald E. Pavey

  DOI：10.1021/jm00181a003

  日期：1980.7

  A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piperazinyl]-6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine 1-oxide hydrochloride. This compound in animal tests was equipotent to the known antihypertensive Prazosin.