在此,我们报告Cp * Co III催化的C H活化方法是创建高度有价值的异喹诺酮和吡啶酮的重要步骤,这些异喹啉酮和吡啶酮可以轻松地用于各种芳香族素,原小ber碱和tylophora生物碱的总合成。这种特殊的CH活化/环化反应是通过多个末端以及内部炔烃偶联伙伴实现的,具有广泛的应用范围和出色的官能团耐受性。本文报道的该方案的合成适用性已在两个Topo-I-抑制剂和两个8-氧代小ber碱核心的合成中得到了证明,这些核心可进一步制成四氢小ber碱和原小ber碱生物碱。此外,这些构件也以方便的方式转化为六种不同的tylophora生物碱。
Rhodium(III)-Catalyzed Intramolecular Annulation through CH Activation: Total Synthesis of (±)-Antofine, (±)-Septicine, (±)-Tylophorine, and Rosettacin
作者:Xianxiu Xu、Yu Liu、Cheol-Min Park
DOI:10.1002/anie.201204970
日期:2012.9.10
Annulation: The efficient synthesis of 3‐hydroxyalkyl isoquinolones and 6‐hydroxyalkyl 2‐pyridones is enabled through the intramolecular annulation of alkyne‐tethered hydroxamic esters (see scheme, Cp*=pentamethylcyclopentadienyl). The reaction features high regioselectivity, broad substrate scope, and excellent functional‐group tolerance, proceeds under mild reaction conditions with low catalyst loading
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include an aminooxy linkage. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
Aminooxy functionalized oligomers, oligomer arrays and methods of using them
申请人:——
公开号:US20030113769A1
公开(公告)日:2003-06-19
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include an aminooxy linkage. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
Enantioselective cyanation of propargylic C–H bonds <i>via</i> cooperative photoredox and copper catalysis
作者:Yunshun Deng、Ronghua Lu、Pinhong Chen、Guosheng Liu
DOI:10.1039/d3cc00410d
日期:——
Herein, we report an enantioselectivecyanation of propargylic C–H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile compounds under mild conditions.