MitoBADY | 1644119-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: MitoBADY
• 英文别名: triphenyl-[[4-(4-phenylbuta-1,3-diynyl)phenyl]methyl]phosphanium;iodide
• CAS: 1644119-76-5
• 化学式: C₃₅H₂₆P*I
• 分子量: 604.47
• InChiKey: UUOLSGIFWSDQDZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  37.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  4-乙炔基苯甲醛 在 copper(l) iodide 、 lithium aluminium tetrahydride 、 nickel(II) chloride hexahydrate 、 四甲基乙二胺 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 27.25h， 生成 MitoBADY
  参考文献：
  名称：

  A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria

  摘要：

  We previously showed that bisarylbutadiyne (BADY), which has a conjugated diyne structure, exhibits an intense peak in the cellular Raman-silent region. Here, we synthesized a mitochondria-selective Raman probe by linking bisphenylbutadiyne with triphenylphosphonium, a well-known mitochondrial targeting moiety. This probe, named MitoBADY, has a Raman peak 27 times more intense than that of 5-ethynyl-2'-deoxyuridine. Raman microscopy using submicromolar extracellular probe concentrations successfully visualized mitochondria in living cells. A full Raman spectrum is acquired at each pixel of the scanned sample, and we showed that simultaneous Raman imaging of MitoBADY and endogenous cellular biomolecules can be achieved in a single scan. MitoBADY should be useful for the study of mitochondrial dynamics. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.11.080