N-(anthracen-2-yl)formamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: N-(anthracen-2-yl)formamide
• 英文别名: N-anthracen-2-ylformamide
• 化学式: C₁₅H₁₁NO
• 分子量: 221.258
• InChiKey: OLGSIQCBRXNNNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲酸 、 2-氨基蒽 生成 N-(anthracen-2-yl)formamide
  参考文献：
  名称：

  The Sociology of Organizations and the Organization of Sociology: Some Reflections on the Making of a Division of Labour

  摘要：

  本文探讨了 "组织研究"--一门主要在管理部门开展的学科--与 "组织社会学 "之间正在出现的分歧。以组织文化为例，我认为 "遗忘 "是构建一门学科的关键步骤。许多组织研究关于企业文化和象征意义的文章，都是基于对大量关于 "氛围"、"气候"、"个性 "和 "非正式结构 "的早期社会学著作的遗忘。这种学科构成是认识的结果，但也涉及到为遗忘划定界限。对这一领域当前的分工以及遗忘的代价进行批判性反思，可能会鼓励更具历史意义的认识形式。

  DOI：

  10.1111/1467-954x.00206

文献信息

• Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines
  作者：Jiawen Yin、Jingyu Zhang、Changqun Cai、Guo-Jun Deng、Hang Gong

  DOI：10.1021/acs.orglett.8b03542

  日期：2019.1.18

  A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this

  已经开发了一种简单的无催化剂和无助催化剂的方案，用于弱亲核芳香胺与甲酰胺衍生物的酰胺交换，以及低反应性叔酰胺与脂族胺的酰胺交换。该策略是有利的，因为不需要催化剂或助催化剂，不需要添加剂，分离和纯化容易，并且反应是可扩展的。重要的是，该策略被进一步应用于以克为单位合成几种药物分子，并获得了优异的收率。
• 一种无催化剂无促进剂条件下芳香胺与酰胺衍生物的转胺反应
  申请人：湘潭大学

  公开号：CN109456216A

  公开（公告）日：2019-03-12

  本发明公开了一种无催化剂无促进剂条件下弱亲核的芳胺与酰胺衍生物的转胺反应，高产率的合成N‑芳基酰胺衍生物的方法。该方法具有底物适用范围广，其原料及酰化试剂廉价易得，反应产率高、一步反应、成本低，反应选择性高，操作简单等优点。采用该方法可以克级规模高产率的实现几种药物分子的合成。因此，该方法在N‑芳基酰胺衍生物的合成应用领域具有很好的应用前景。该方法克服了现有技术如反应试剂毒性大，需要使用不同类型催化剂、合成方法成本较高、反应步骤多，副产物多等缺陷。
• The Sociology of Organizations and the Organization of Sociology: Some Reflections on the Making of a Division of Labour
  作者：Martin Parker

  DOI：10.1111/1467-954x.00206

  日期：2000.2

  This paper speculates on the emerging divide between ‘organization studies’ – a discipline largely practised in management departments – and the ‘sociology of organizations’. Using organizational culture as a case study, I argue that ‘forgetting’ is a key move in the construction of a discipline. Much organization studies' writing on corporate culture and symbolism is predicated on an amnesia about a wide body of older sociological work on ‘atmosphere’, ‘climate’, ‘personality’ and ‘informal structure’. This disciplinary constitution is productive of knowing, yet it also involves drawing boundaries that enable forgetting. Critically reflecting on the current division of labour in this area, as well as on the costs of amnesia, might encourage more historically informed forms of knowing.

  本文探讨了 "组织研究"--一门主要在管理部门开展的学科--与 "组织社会学 "之间正在出现的分歧。以组织文化为例，我认为 "遗忘 "是构建一门学科的关键步骤。许多组织研究关于企业文化和象征意义的文章，都是基于对大量关于 "氛围"、"气候"、"个性 "和 "非正式结构 "的早期社会学著作的遗忘。这种学科构成是认识的结果，但也涉及到为遗忘划定界限。对这一领域当前的分工以及遗忘的代价进行批判性反思，可能会鼓励更具历史意义的认识形式。
• Anticancer potential of aminomethylidene-diazinanes I. Synthesis of arylaminomethylidene of diazinetriones and its cytotoxic effects tested in glioblastoma cells
  作者：Nichole A. Pianovich、Mathew Dean、Adam Lassak、Krzysztof Reiss、Branko S. Jursic

  DOI：10.1016/j.bmc.2017.08.020

  日期：2017.10

  Diazinane and aryl moieties with vinylamine linkers were synthesized to investigate the importance of their structural variations as potential anti-glioblastoma agents. Structural variations incorporated on to the diazinane moiety included oxa and thio derivatives, each with a variety of nitrogen-bound substituents. The size and shape of the aromatic moiety was varied, with the final variation introducing two carbonyl groups, yielding a substituted anthraquinone. Readily available diazinanes and aryl amines were used as an advantageous foundation. Several parameters were calculated whilst engineering these compounds, including: Clog P, molecular polarizability, polar surface area, minimal molecular projected area, and pK(a). In addition, a simple and efficient procedure was developed to synthesize these compounds. It was demonstrated that a vinylamine with 1,3-diazinane-2,4,6-trione and 1-anthraquinone moiety is the most promising drug candidate causing almost 70% of LN229 tumor cell death at 1 mu g/ml. In addition, its molecular polarizability, polar surface area and minimal molecular projected area indicate a possible potential of this molecule for crossing BBB. (C) 2017 Published by Elsevier Ltd.
• [EN] BENZOYLUREA COMPOUND AND USE THEREOF<br/>[FR] COMPOSE BENZOYLUREE ET SON UTILISATION
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2007066496A1

  公开（公告）日：2007-06-14

  [EN] The present invention relates to a benzoylurea compound represented by the formula (1): wherein R² represents a lower alkylene group etc., and A represents a group represented by OR³, S(O) _nR⁴ or NR⁵R⁶, or a salt thereof, and use of the same for controlling pests.
  [FR] La présente invention concerne un composé benzoylurée représenté par la formule (1) : dans laquelle R² représente un groupe alkylène inférieur, etc. et A représente un groupe représenté par OR³, S(O)_nR⁴ ou NR⁵R⁶, ou un sel de celui-ci, et son utilisation pour lutter contre les parasites.