2-Dimethylamino-5,6-benzo-1,3,2-dioxaphosphepine | 69813-53-2

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 2-Dimethylamino-5,6-benzo-1,3,2-dioxaphosphepine
• 英文别名: N,N-dimethyl-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amine
• CAS: 69813-53-2
• 化学式: C₁₀H₁₄NO₂P
• 分子量: 211.2
• InChiKey: YCQMIZJFTHXPDY-UHFFFAOYSA-N

物化性质

• 沸点：
  78-80 °C(Press: 0.03 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Dimethylamino-5,6-benzo-1,3,2-dioxaphosphepine 在 sulfur 作用下， 以 苯 为溶剂， 生成 sulfide of 2-dimethylamino-5,6-benzo-1,3,2-dioxaphosphepine
  参考文献：
  名称：

  Steric structure of phosphorus-containing heterocycles Communication 36. 2-dialkylamino-1,3,2-dioxaphosphepines with tetracoordinated phosphorus

  摘要：

  DOI：

  10.1007/bf00948045
• 作为产物：
  描述：

  邻苯二甲醇 、 三(二甲胺基)膦 以 乙酸乙酯 、 甲苯 为溶剂， 反应 3.0h， 以63%的产率得到2-Dimethylamino-5,6-benzo-1,3,2-dioxaphosphepine
  参考文献：
  名称：

  Spatial structure of phosphorus-containing heterocycles

  摘要：

  DOI：

  10.1007/bf00949773

文献信息

• The synthesis of homochiral inositol phosphates from myo-inositol
  作者：K.Michał Pietrusiewicz、Grzegorz M. Salamończyk、Karol S. Bruzik、Wanda Wieczorek

  DOI：10.1016/s0040-4020(01)88305-8

  日期：1992.1

  conversion of myo-inositol into homochiral inositol phosphates is presented, and is illustrated with total synthesis of myo-inositol 1-phosphate, 2-deoxy-myo-inositol 1-phosphate, myo-inositol 3-phosphate, myo-inositol 4-phosphate, myo-inositol 1,4-bisphosphate, myo-inositol 1,4,5-trisphosphate, and myo-inositol 3,4,5,6-tetrakisphosphate. The syntheses start with selfresolving myo-inositol camphanylidene

  高效转换的一个新的合成方法肌醇肌醇成纯手性肌醇磷酸被呈现，并且与全合成所示肌醇-1-磷酸，2-脱氧肌醇-1-磷酸，肌醇肌醇-3-磷酸，肌肌醇-4-磷酸，肌醇肌醇1,4-二磷酸，肌醇肌醇1,4,5-三磷酸和肌醇肌醇3,4,5,6-四磷酸盐。该合成开始selfresolving肌肌醇camphanylidene顺-monoacetals 2A和2A'分别从母体环糖醇和D-和L-樟脑二甲基缩醛一步获得，并通过沉淀驱动的平衡方便地收获。合成的关键步骤是2a和2a'的选择性单磷酸化，选择性双甲硅烷基化和选择性三酰基化，以及使用二氯磷酸二苄酯和2-二甲氨基-5,6-苯并-1,3,2-二氧杂磷杂环戊烷来实现单磷酸化和多磷酸化。为了支持立体化学分配，还提出了一种中间体完全保护的肌醇衍生物之一的X射线结构。
• Synthesis of enantiomerically pure D-myo-inositol 1,5,6-triphosphate
  作者：Grzegorz M. Salamończyk、K.Michał Pietrusiewicz

  DOI：10.1016/s0040-4039(00)73160-1

  日期：1994.6

  The synthesis of enantiomerically pure D-myo-inositol 1,5,6-triphosphate from myo-inositol involving two sequential regioselective protections of hydroxyl groups in the intermediate selfresolving myo-inositol camphor monoacetal has been accomplished

  对映体纯D-的合成肌肉肌醇1,5,6三磷酸从肌醇肌醇涉及羟基的两个连续的区域选择性的保护在中间selfresolving肌醇肌醇樟脑单缩醛已经完成
• NOVEL NK374186 ANALOGUES OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0866074A1

  公开（公告）日：1998-09-23

  NK374186 analogues such as NK374186A3 of formula (I). NK374186D3 and NK374186E3 can be obtained by culturing NK374186-producing bacteria. Other NK374186 analogues are obtained by chemically derivatizing NK374186B. These analogues and pharmacologically acceptable salts thereof are useful as the active ingredients of antitumor drugs and immunoregulators.

  NK374186 类似物，如式 (I) 的 NK374186A3、NK374186D3 和 NK374186E3。NK374186D3 和 NK374186E3 可通过培养产生 NK374186 的细菌获得。其他 NK374186 类似物可通过对 NK374186B 进行化学衍生获得。这些类似物及其药理学上可接受的盐类可用作抗肿瘤药物和免疫调节剂的活性成分。
• Synthesis and conformational analysis of torsionally constrained 1,3,2-dioxaphosphepanes
  作者：William N. Setzer、Milton L. Brown、Xiao Jing Yang、Melody A. Thompson、Kylen W. Whitaker

  DOI：10.1021/jo00036a011

  日期：1992.5

  A series of benzo-fused and norbornene-fused 1,3,2-dioxaphosphepanes have been synthesized and conformationally studied by proton and phosphorus-31 NMR, infrared spectroscopy, and X-ray crystallography. The NMR data are best interpreted in terms of chair-chair equilibria in which substituents on phosphorus (phenoxy, dimethylamino, and phenyl) show a remarkable preference for axial positions. Twist conformations cannot be completely ruled out, however. X-ray crystal structures have been determined for two of the norbornene-fused compounds, trans-5,6-(endo,endo-2',3'-bicyclo[2.2.1]hept-5'-eno)-2-oxo-2-phenoxy-1,3,2-dioxaphosphepane (trans-2a) and trans-5,6-(endo,endo-2',3'-bicyclo[2.2.l]hept-5'-eno)-2-oxo-2-phenyl-1,3,2-dioxaphosphepane (trans-2b), and one of the benzo-fused compounds, 5,6-benzo-2-oxo-2-phenyl-1,3,2-dioxaphosphepane (1b). The X-ray structures of the two norbornene-fused dioxaphosphepanes confirm the stereochemical assignments for these materials and show the seven-membered ring to adopt a chair conformation. A twist conformation is seen in the structure of the benzo-fused dioxaphosphepane, on the other hand.
• Five monophosphates of methyl l-glycero-α-d-manno-heptopyranoside: synthesis, hydrolysis and migrations
  作者：Barbara Grzeszczyk、Otto Holst、Sven Müller-Loennies、Aleksander Zamojski

  DOI：10.1016/s0008-6215(98)00037-8

  日期：1998.2

  From suitably protected methyl alpha-D-mannopyranosides five methyl L-glycero-alpha-D-manno-heptopyranosides were synthesized by the one-carbon-atom chain elongation at C-6 and converted to five monophosphates (1-5) having the PO(OH)(2) group at O-2, -3, -4, -6 and -7. Compounds 1-5 were exposed to acidic and basic hydrolytic conditions used in lipopolysaccharide analysis and the products and their proportion were determined. Under acidic conditions, besides hydrolysis of the glycoside, migrations and hydrolytic cleavage of the phosphate residue were found. Under basic conditions the phosphates were stable. (C) 1998 Elsevier Science Ltd. All rights reserved.