N-(9-oxo-9H-fluoren-2-yl)formamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-(9-oxo-9H-fluoren-2-yl)formamide
• 英文别名: 2-Formamido-9-fluorenone；N-(9-oxofluoren-2-yl)formamide
• 化学式: C₁₄H₉NO₂
• 分子量: 223.231
• InChiKey: VERIQMZSHJWSCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(9-oxo-9H-fluoren-2-yl)formamide 在 甲醇 、 sodium tetrahydroborate 作用下， 以66 %的产率得到N-(9-hydroxy-9H-fluoren-2-yl)formamide
  参考文献：
  名称：

  METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS

  摘要：

  本公开涉及的是从扩增的CD34+细胞来源中在培养中准备定义谱系的寡能和单能祖细胞的方法和系统，用于制备相应的培养基，以及包含相应的治疗化合物和组合物，用于治疗各种疾病，包括但不限于血液学疾病、免疫性疾病、癌症和传染性疾病。

  公开号：

  US20220315895A1
• 作为产物：
  描述：

  2-氨基芴 在 copper(l) iodide 、 2,2,6,6-四甲基哌啶氧化物 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 ytterbium(III) triflate 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 N-(9-oxo-9H-fluoren-2-yl)formamide
  参考文献：
  名称：

  Copper Promoted Aerobic Oxidative C(sp³)–C(sp³) Bond Cleavage of N-(2-(Pyridin-2-yl)-ethyl)anilines

  摘要：

  A strategy of aerobic oxidative C(sp³)-C(sp³) bond cleavage of N-ethylaniline derivatives bearing azaarenes for the synthesis of N-aryl formamides has been developed. This approach was carried out smoothly with the CuI/TEMPO/air system to give N-aryl formamides in yields of 50-90%. With this methodology, a mutagenically active compound was constructed in 90% yield. Moreover, the reaction also provided a one-pot synthetic tool for accessing a promoter of hematopoietic stem cells by difunctionalization in 61% yield.

  DOI：

  10.1021/acs.joc.9b02919

文献信息

• [EN] COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES EXPANSÉES METTANT EN OEUVRE DES DÉRIVÉS DE FLUORÈNE
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2019084452A1

  公开（公告）日：2019-05-02

  This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

  这项发明涉及一些内容，包括用于维持、增强和扩展来源于一个或多个CD34+细胞源的造血干细胞的化合物、方法、系统和组合物。CD34+细胞的来源包括骨髓、脐带血、动员的外周血和非动员的外周血。本文还提供了一些Formula I的化合物，这些化合物在维持、增强和扩展造血干细胞方面是有用的。
• US7265130B2
  申请人：——

  公开号：US7265130B2

  公开（公告）日：2007-09-04
• [EN] METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS<br/>[FR] PROCÉDÉS DE FABRICATION DE PRÉCURSEURS OLIGOPOTENTS ET UNIPOTENTS
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2020223517A1

  公开（公告）日：2020-11-05

  This disclosure is directed to, inter alia, methods and systems for preparing oligopotent and unipotent progenitor cells of defined lineages in culture from an expanded source of CD34+ cells, media for making the same, and therapeutic compounds and compositions comprising the same for treatment a variety of diseases included, but not limited to, hematologic disorders, immune diseases, cancers, and infectious diseases.
• Copper Promoted Aerobic Oxidative C(sp³)–C(sp³) Bond Cleavage of <i>N</i>-(2-(Pyridin-2-yl)-ethyl)anilines
  作者：Yang Yu、Yong Zhang、Chengyu Sun、Lei Shi、Wei Wang、Hao Li

  DOI：10.1021/acs.joc.9b02919

  日期：2020.2.21

  A strategy of aerobic oxidative C(sp³)-C(sp³) bond cleavage of N-ethylaniline derivatives bearing azaarenes for the synthesis of N-aryl formamides has been developed. This approach was carried out smoothly with the CuI/TEMPO/air system to give N-aryl formamides in yields of 50-90%. With this methodology, a mutagenically active compound was constructed in 90% yield. Moreover, the reaction also provided a one-pot synthetic tool for accessing a promoter of hematopoietic stem cells by difunctionalization in 61% yield.
• METHODS OF MAKING OLIGOPOTENT AND UNIPOTENT PRECURSORS
  申请人：Transfusion Health, LLC

  公开号：US20220315895A1

  公开（公告）日：2022-10-06

  This disclosure is directed to, inter alia, methods and systems for preparing oligopotent and unipotent progenitor cells of defined lineages in culture from an expanded source of CD34+ cells, media for making the same, and therapeutic compounds and compositions comprising the same for treatment a variety of diseases included, but not limited to, hematologic disorders, immune diseases, cancers, and infectious diseases.

  本公开涉及的是从扩增的CD34+细胞来源中在培养中准备定义谱系的寡能和单能祖细胞的方法和系统，用于制备相应的培养基，以及包含相应的治疗化合物和组合物，用于治疗各种疾病，包括但不限于血液学疾病、免疫性疾病、癌症和传染性疾病。