6-Bromo-2,3-dimethoxy-5-methylhydroquinone bis<2-methoxyethoxymethyl ether> | 73875-28-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-Bromo-2,3-dimethoxy-5-methylhydroquinone bis<2-methoxyethoxymethyl ether>
• 英文别名: 6-bromo-2,3-dimethoxy-5-methyl-1,4-hydroquinone bis(2-methoxyethoxymethyl ether)；1-Bromo-3,4-dimethoxy-2,5-bis[(2-methoxyethoxy)methoxy]-6-methylbenzene；1-bromo-3,4-dimethoxy-2,5-bis(2-methoxyethoxymethoxy)-6-methylbenzene
• CAS: 73875-28-2
• 化学式: C₁₇H₂₇BrO₈
• 分子量: 439.301
• InChiKey: XISQJFKLZIPAJR-UHFFFAOYSA-N

物化性质

• 沸点：
  478.7±45.0 °C(Predicted)
• 密度：
  1.283±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-Bromo-2,3-dimethoxy-5-methylhydroquinone bis<2-methoxyethoxymethyl ether> 在 碘 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 Grignard reagent 6-bromo-2,3-dimethoxy-5-methyl-1,4-hydroquinone bis(2-methoxyethoxymethyl ether)
  参考文献：
  名称：

  Novel Intermediates, Process for Their Preparation and Process for the Preparation of Coq10 Employing the Said Novel Intermediates

  摘要：

  本发明涉及一种改进的辅酶Q制备过程。辅酶Q10或CoQ10的化学名称为2-[(全反式)-3,7,11,15,19,23,27,31,35,39-十甲基-2,6,10,14,18,22,26,30,34,38-四十烷基]-5,6-二甲氧基-3-甲基-1,4-苯醌，化学式为I。该发明还提供了用于制备CoQ10的新中间体及其制备过程。

  公开号：

  US20080200702A1
• 作为产物：
  描述：

  2,3-二甲氧基-5-甲基-1,4-苯二酚 在 溴 、 sodium hydride 、 mineral oil 作用下， 以 氯仿 为溶剂， 反应 3.5h， 生成 6-Bromo-2,3-dimethoxy-5-methylhydroquinone bis<2-methoxyethoxymethyl ether>
  参考文献：
  名称：

  A New Efficient Method for the Preparation of Sulfone-Functionalized Prenylhydroquinones

  摘要：

  DOI：

  10.1055/s-1981-29490

文献信息

• Novel Intermediates Useful for the Preparation of Coenzymes, Process for the Preparation of Novel Intermediates and an Improved Process for the Preparation of Coenzymes
  申请人：Upare Abhay

  公开号：US20080200732A1

  公开（公告）日：2008-08-21

  The present invention relates to novel intermediates for the preparation of coenzymes, processes for the preparation of the intermediates and an improved process for the preparation of Coenzymes. The present invention particularly relates to an improved process for the preparation of Coenzyme Q, more particularly for Conenzyme Q 9 and Coenzyme Q 10 . Still more particularly this invention relates to regio and stereo controlled process for the preparation of Coenzyme Q 9 and Coenzyme Q 10 of the formula I where n=9 (Coenzyme CoQ 9 ), and where n=10. (Coenzyme CoQ 10 )

  本发明涉及用于制备辅酶的新型中间体，制备中间体的方法以及制备辅酶的改进方法。本发明特别涉及一种用于制备辅酶Q的改进方法，更具体地用于辅酶Q9和辅酶Q10。更具体地说，本发明涉及一种用于制备辅酶Q9和辅酶Q10的区域和立体控制方法，其化学式为n=9（辅酶CoQ9），n=10（辅酶CoQ10）。
• FUJITA YOSHIJI; ISHIGURO MICHIHIRO; ONISHI TAKASHI; NISHIDA TAKASHI, SYNTHESIS (BRD), 1981, NO 6, 469-471
  作者：FUJITA YOSHIJI、 ISHIGURO MICHIHIRO、 ONISHI TAKASHI、 NISHIDA TAKASHI

  DOI：——

  日期：——
• [EN] NOVEL INTERMEDIATES USEFUL FOR THE PREPARATION OF COENZYMES, PROCESS FOR THE PREPARATION OF NOVEL INTERMEDIATES AND AN IMPROVED PROCESS FOR THE PREPARATION OF COENZYMES<br/>[FR] NOUVEAUX INTERMEDIAIRES UTILISES DANS LA PREPARATION DE COENZYMES, PROCESSUS DE PREPARATION DE NOUVEAUX INTERMEDIAIRES ET PROCESSUS AMELIORE DESTINE A LA PREPARATION DE COENZYMES
  申请人：NICHOLAS PIRAMAL INDIA LTD

  公开号：WO2007004091A2

  公开（公告）日：2007-01-11

  [EN] The present invention relates to novel intermediates for the preparation of coenzymes, processes for the preparation of the intermediates and an improved process for the preparation of Coenzymes. The present invention particularly relates to an improved process for the preparation of Coenzyme Q , more particularly for Conenzyme Q₉ and Coenzyme Q₁₀. Still more particularly this invention relates to regio and stereo controlled process for the preparation of Coenzyme Q₉ and Coenzyme Q₁₀ of the formula (I), where n = 9 (Coenzyme CoQ₉) , and where n = 10. (Coenzyme CoQ₁₀).
  [FR] La présente invention concerne de nouveaux intermédiaires dans la préparation de coenzymes, des processus de préparation desdits intermédiaires et un processus amélioré destiné à la préparation de coenzymes. Cette invention a, notamment, pour objet un processus amélioré de préparation du coenzyme Q, plus spécifiquement, du conenzyme Q₉ et du coenzyme Q₁₀. Encore plus particulièrement, ladite invention concerne un processus régio- et stéréo-régulé pour la préparation du conenzyme Q₉ et du coenzyme Q₁₀ de formule (I), où n = 9 (coenzyme CoQ₉), et où n = 10 (coenzyme CoQ₁₀).
• Novel Intermediates, Process for Their Preparation and Process for the Preparation of Coq10 Employing the Said Novel Intermediates
  申请人：Gurumurthy Palanivelu

  公开号：US20080200702A1

  公开（公告）日：2008-08-21

  The present invention relates to an improved process for the preparation of Coenzyme Q. Coenzyme Q 10 or CoQ 10 has the chemical name 2-[(all-trans)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone and has the formula I. The invention also provides new intermediates useful for the preparation of CoQ 10 and processes for their preparation.

  本发明涉及一种改进的辅酶Q制备过程。辅酶Q10或CoQ10的化学名称为2-[(全反式)-3,7,11,15,19,23,27,31,35,39-十甲基-2,6,10,14,18,22,26,30,34,38-四十烷基]-5,6-二甲氧基-3-甲基-1,4-苯醌，化学式为I。该发明还提供了用于制备CoQ10的新中间体及其制备过程。
• A New Efficient Method for the Preparation of Sulfone-Functionalized Prenylhydroquinones
  作者：Yoshiji Fujita、Michihiro Ishiguro、Takashi Onishi、Takashi Nishida

  DOI：10.1055/s-1981-29490

  日期：——