7-benzyloxy-2H-dibenzo[cd,g]indazol-6-one | 678970-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 7-benzyloxy-2H-dibenzo[cd,g]indazol-6-one
• 英文别名: 7-benzyloxyanthra[1,9cd]pyrazol-6(2H)-one；6-Phenylmethoxy-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one
• CAS: 678970-83-7
• 化学式: C₂₁H₁₄N₂O₂
• 分子量: 326.354
• InChiKey: BINVTANIRBHMGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-benzyloxy-2H-dibenzo[cd,g]indazol-6-one 、 2-甲氧基乙氧基甲基氯 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 3-(2-methoxyethoxymethyl)-7-benzyloxyanthra[1,9cd]pyrazol-6(2H)-one
  参考文献：
  名称：

  Methods for treating inflammatory conditions or inhibiting JNK

  摘要：

  本发明通常涉及治疗或预防炎症性疾病或紊乱的方法，包括向需要治疗的患者施用以下结构的吡唑酮衍生物的有效量：1或其药学上可接受的盐，其中R1和R2如此处所定义。

  公开号：

  US20040072888A1

文献信息

• Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
  申请人：——

  公开号：US20040087642A1

  公开（公告）日：2004-05-06

  The present invention relates to methods for treating, preventing, managing and/or modifying pain, comprising administering an effective amount of a JNK Inhibitor to a patient in need thereof. Specific embodiments encompass the administration of a JNK Inhibitor, alone or in combination with a second active agent and/or surgery or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

  本发明涉及治疗、预防、控制和/或改变疼痛的方法，包括向有需要的患者施用有效量的JNK抑制剂。具体的实施方案包括单独或与第二种活性剂和/或手术或物理疗法联合使用 JNK 抑制剂。本发明还公开了适用于本发明方法的药物组合物、单一单位剂型和试剂盒。
• Composition for collecting and preserving placental stem cells and methods of using the composition
  申请人：Edinger W. James

  公开号：US20070190042A1

  公开（公告）日：2007-08-16

  The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.
• Methods of Using and Compositions Comprising a Jnk Inhibitor for the Treatment and Management of Asbestos-Related Diseases and Disorders
  申请人：Zeldis B. Jerome

  公开号：US20070270448A1

  公开（公告）日：2007-11-22

  Methods for treating, preventing and/or managing an asbestos-related disease or disorder are disclosed. Specific embodiments encompass the administration of a JNK Inhibitor, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or chemotherapy, surgery, or radiation therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in the methods of the invention are also disclosed.
• COMPOSITION FOR COLLECTING AND PRESERVING PLACENTAL STEM CELLS AND METHODS OF USING THE COMPOSITION
  申请人：Edinger James W.

  公开号：US20100291679A1

  公开（公告）日：2010-11-18

  The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.
• US7335676B2
  申请人：——

  公开号：US7335676B2

  公开（公告）日：2008-02-26