2-(2'-hydroxyethyl)-4,5,6-triphenyl-2H-pyridazin-3-one | 75644-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2'-hydroxyethyl)-4,5,6-triphenyl-2H-pyridazin-3-one
• 英文别名: 2-(2-hydroxyethyl)-4,5,6-triphenylpyridazin-3-one
• CAS: 75644-19-8
• 化学式: C₂₄H₂₀N₂O₂
• 分子量: 368.435
• InChiKey: KMKGLRBPIDMTJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,5,6-triphenyl-3(2H)-pyridazinone 、 2-氯乙醇 在 sodium hydroxide 作用下， 以 N-甲基乙酰胺 、 甲醇 、 水 为溶剂， 以25%的产率得到2-(2'-hydroxyethyl)-4,5,6-triphenyl-2H-pyridazin-3-one
  参考文献：
  名称：

  Antihypertensive pyridazin(2H)-3-ones

  摘要：

  式为##STR1##的化合物是有用的降压剂。

  公开号：

  US04238490A1

文献信息

• Pyridazin (2H)-3-ones, process for their preparation and their use in antihypertensive agents
  申请人：DIAMOND SHAMROCK CORPORATION

  公开号：EP0018063A1

  公开（公告）日：1980-10-29

  Substituted keto-pyridazine compounds of the formula where R, and R7 are substituents selected from atoms and groups as listed in the disclosure and X and Y denote the same or different optional substituents also selected as listed in the disclosure, are new compounds which are useful antihypertensive agents. The methods of preparation and properties of examples of the compounds are given, together with their use as antihypertensive agents.

  式中的取代酮哒嗪化合物 其中 R 和 R7 是选自公开文献中所列原子和基团的取代基，X 和 Y 表示相同或不同的任选取代基，也选自公开文献中所列基团。本文给出了这些化合物的制备方法和性质实例，以及它们作为降压药的用途。
• Beta-lactam compound and a pharmaceutical composition containing the same
  申请人：KYOWA HAKKO KOGYO CO., LTD

  公开号：EP0075805A1

  公开（公告）日：1983-04-06

  β-Lactam compounds represented by the general formula: (wherein X represents CH2, S or O; Y represents a hydroxyl group, lower alkanoyloxy group, amino group or substituted amino group; A represents a phenyl group, naphthyl group, or monocyclic or dicyclic heterocyclic group, respectively substituted by (Y)n; R4 and R5 each represent a hydrogen atom, lower alkyl group or cycloalkylidene group together with the carbon atom combined therewith; represents an integer of 0,1,2 or 3; m represents an integer of 0 or 1; and n represents an integer of 1, 2, 3, 4 or 5; and R1, R2 and R3 are groups often used in the conventional β-lactam compounds) have strong antimicrobial activities against a wide range of Gram positive and negative bacteria; particularly Gram negative bacteria including Pseudomonas aeruginosa, Pseudomonas sepatia and various Enterobacters.

  由通式代表的β-内酰胺化合物： (其中 X 代表 CH2、S 或 O；Y 代表羟基、低级烷酰氧基、氨基或取代氨基；A 代表苯基、萘基或分别被 (Y)n 取代的单环或双环杂环基团；R4 和 R5 分别代表氢原子、低级烷基或环亚烷基及其结合的碳原子；代表 0、1、2 或 3 的整数；m 代表 0 或 1 的整数；n 代表 1、2、3、4 或 5 的整数；R1、R2 和 R3 是常规 β-内酰胺化合物中常用的基团）对多种革兰氏阳性和阴性细菌具有很强的抗菌活性，尤其是革兰氏阴性细菌，包括铜绿假单胞菌、败血假单胞菌和各种肠杆菌。
• Antihypertensive 5,6-diarylpyridazin-3-ones
  作者：Russell Buchman、James A. Scozzie、Zaven S. Ariyan、Richard D. Heilman、Donna J. Rippin、W. J. Pyne、Larry J. Powers、Richard J. Matthews

  DOI：10.1021/jm00186a021

  日期：1980.12

  The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent compounds in the series have halogen substituents on the 5,6-diphenyl rings, a beta-substituted alkyl group at the 2 position of the ring, and acetyl or cyano substituent at the 4 position.
• BUCHMAN R.; SCOZZIE J. A.; AKIYAN Z. S.; HEILMAN R. D.; RIPPIN D. J.; PYN+, J. MED. CHEM., 1980, 23, NO 12, 1398-1405
  作者：BUCHMAN R.、 SCOZZIE J. A.、 AKIYAN Z. S.、 HEILMAN R. D.、 RIPPIN D. J.、 PYN+

  DOI：——

  日期：——
• US4238490A
  申请人：——

  公开号：US4238490A

  公开（公告）日：1980-12-09