3-chloro-1-isopropyl-pyrrolidine | 14398-84-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-chloro-1-isopropyl-pyrrolidine
• 英文别名: 1-isopropyl-3-chloropyrrolidine；1-Isopropyl-3-chlor-pyrrolidin；3-chloro-1-propan-2-ylpyrrolidine
• CAS: 14398-84-6
• 化学式: C₇H₁₄ClN
• 分子量: 147.648
• InChiKey: LNXOIVZJWDNICI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-chloro-1-isopropyl-pyrrolidine 、 二苯乙腈 以 水 、 甲苯 为溶剂， 生成 (1-isopropyl-pyrrolidin-3-yl)-diphenyl-acetonitrile
  参考文献：
  名称：

  Antiarrhythmia methods

  摘要：

  本发明涉及1-R-3-Pyrrolidinyl-.alpha.,.alpha.-diphenylacetamides, -acetonitriles和-methanes，其化学式如下：##STR1## 其中R代表氢、较低的烷基、较低的环烷基或苯基较低的烷基，R.sup.1代表氢或较低的烷基，Y代表氨基甲酰基、二较低的烷基氨基甲酰基、吡咯烷基甲酰基、吗啉基甲酰基、氰基或氢，具有抗心律失常活性。本发明还包括药学上可接受的酸盐作为发明的一部分。

  公开号：

  US04002766A1

文献信息

• A new class of histamine H3 receptor antagonists derived from ligand based design
  作者：Olivier Roche、Rosa María Rodríguez Sarmiento

  DOI：10.1016/j.bmcl.2007.04.056

  日期：2007.7

  Design and synthesis of highly potent and selective non-imidazole inverse agonists for the histamine H-3 receptor is described. The study validates a new pharmacophore model based on the merging of two previously described models. It also demonstrates that the removal of the basic center potentially interacting with ASP3.32 and common to both models leads to loss of activity, whereas the replacement of the second basic center by an acceptor retains the potency. 14 (c) 2007 Elsevier Ltd. All rights reserved.
• Inhibitors of post-proline cleaving proteases
  申请人：Evans David M.

  公开号：US20080255126A1

  公开（公告）日：2008-10-16

  Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R 1 is H or CN, X 1 is O, S, CH 2 , CHF, CF 2 , CH(CH 3 ), C(CH 3 ) 2 or CH(CN), and b is 1 or 2. G 1 is H or a group according to the formula —CH 2 —X 2 —(CH 2 ) a -G 3 and G 2 is H or a group according to the formula —CH 2 —(CH 2 9 a -G 3 , provided that one of G 1 and G 2 is H and the other is not H. X 2 is O, S, or CH 2 , and a is 0, 1 or 2, provided that when a is 1 then X 2 is CH 2 . G 3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.
• US3984557A
  申请人：——

  公开号：US3984557A

  公开（公告）日：1976-10-05
• US4002766A
  申请人：——

  公开号：US4002766A

  公开（公告）日：1977-01-11
• US5109013A
  申请人：——

  公开号：US5109013A

  公开（公告）日：1992-04-28