1,3-二甲氧基-1,3-二甲基脲 | 123707-26-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,3-二甲氧基-1,3-二甲基脲
• 英文名称: N,N'-dimethoxy-N,N'-dimethyl urea
• 英文别名: N,N'-dimethoxy-N,N'-dimethylurea；N,N'-dimethyl-N,N'-dimethoxyurea；1,3-Dimethoxy-1,3-dimethylurea
• CAS: 123707-26-6
• 化学式: C₅H₁₂N₂O₃
• 分子量: 148.162
• InChiKey: BXBKNWRSAAAPKG-UHFFFAOYSA-N

物化性质

• 沸点：
  42°C/0.1mmHg(lit.)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  3
• 储存条件：
  0-10°C；应避免加热。

反应信息

• 作为反应物：
  描述：

  1,3-二甲氧基-1,3-二甲基脲 、 phenylmagnesium bromide 以 四氢呋喃 为溶剂， 以77%的产率得到N-甲基-N-甲基苯甲酰胺
  参考文献：
  名称：

  Use of N,N'-dimethoxy-N,N'-dimethylurea as a carbonyl dication equivalent in organometallic addition reactions. Synthesis of unsymmetrical ketones

  摘要：

  DOI：

  10.1021/jo00008a057
• 作为产物：
  描述：

  三光气 、 二甲羟胺盐酸盐 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以78%的产率得到1,3-二甲氧基-1,3-二甲基脲
  参考文献：
  名称：

  Use of N,N'-dimethoxy-N,N'-dimethylurea as a carbonyl dication equivalent in organometallic addition reactions. Synthesis of unsymmetrical ketones

  摘要：

  DOI：

  10.1021/jo00008a057

文献信息

• Tandem organometallic addition reactions to N-methoxy-ureas and urethanes in the preparation of unsymmetrical and symmetrical ketones
  作者：Dennis J. Hlasta、John J. Court

  DOI：10.1016/s0040-4039(00)99576-5

  日期：——

  The use of the novel reagents 1a–c for the synthesis of ketones in a one pot reaction is described. An interesting leaving group effect was discovered in the fragmentation of the proposed complexes 2 to the intermediate N-methoxyamides 3.

  描述了在单罐反应中使用新型试剂1a-c合成酮的方法。在提议的复合物2裂解为中间体N-甲氧基酰胺3的过程中发现了一个有趣的离去基团效应。
• Practical routes to diacetylenic ketones and their application for the preparation of alkynyl substituted pyridines, pyrimidines and pyrazoles
  作者：Mauro F.A Adamo、Robert M Adlington、Jack E Baldwin、Gareth J Pritchard、Richard E Rathmell

  DOI：10.1016/s0040-4020(03)00244-8

  日期：2003.3

  Alkynyl substituted pyridines, pyrimidines and pyrazoles have been synthesised by cyclocondensations of diacetylenic ketones with enamines, amidines and hydrazines, respectively.

  炔基取代的吡啶，嘧啶和吡唑分别通过二炔酮与烯胺，am和肼的环缩合反应合成。
• 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents
  申请人：Berger Markus

  公开号：US20090137564A1

  公开（公告）日：2009-05-28

  The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.

  本发明涉及公式I的化合物，其生产过程以及作为抗炎药物的用途。
• Synthesis of a C1−C21 Subunit of the Protein Phosphatase Inhibitor Tautomycin:  A Formal Total Synthesis
  作者：James A. Marshall、Mathew M. Yanik

  DOI：10.1021/jo0056951

  日期：2001.2.1

  The synthesis of a C1-C21 subunit of tautomycin is described. The convergent route employs enantioenriched allenylstannane and zinc reagents derived from (S)-3-butyn-2-ol methanesulfonate. These reagents react with appropriate aldehyde segments to yield syn and anti adducts with high diastereoselectivity. The derived lithioalkynes are joined stepwise to a CO equivalent, (MeONMe)2C=O, to afford an intermediate

  描述了互变霉素C1-C21亚基的合成。收敛路线采用了对映体富集的烯丙基锡烷和衍生自（S）-3-butyn-2-ol甲磺酸盐的锌试剂。这些试剂与适当的醛链段反应，以高非对映选择性产生顺式和反加合物。将衍生的硫代炔烃逐步连接至CO当量（MeONMe）2 C ＝ O，以提供中间体酮，该中间体酮在酸处理后转化为互变异构体的核心螺缩酮部分。通过将上述烯丙基锌试剂另一种添加到螺酮醛中来进行链延长，以高非对映选择性进行，以安装剩余的立体中心。所得的炔丙醇加合物通过炔烃的分子内氢化硅烷化和衍生的五元硅氧烷的Tamoo氧化而转化为甲基酮。该酮被证明与张伯林在先前的互变异构全合成中使用的中间体相同。
• Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes
  申请人：Matsuoka Hiroharu

  公开号：US20080318874A1

  公开（公告）日：2008-12-25

  A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH 2 —, or —NH—; n is an integer selected between 0 and 1; R 6 and R 7 each independently is hydrogen or C 1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q 1 to Q 5 ; Ar 1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar 2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.

  一种环己烷衍生物，具有降低血糖水平的功能，并具有药物所需的优良特性，如持久的药物活性、代谢稳定性和安全性；以及用于预防或治疗与高血糖相关的疾病，如糖尿病，例如胰岛素依赖性糖尿病（1型糖尿病）或非胰岛素依赖性糖尿病（2型糖尿病），糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：（其中A是-O-、-CH2-或-NH-；n是在0和1之间选择的整数；R6和R7各自独立地是氢或C1-6烷基；m是在1-3之间选择的整数；Q在以下式Q1至Q5之间选择；Ar1是可选的取代芳基或可选的取代杂环芳基，但杂环芳基可以与芳香环或芳香杂环结合形成融合环；Ar2是可选的取代芳基或可选的取代杂环芳基），该化合物的前药物或任一药物学上可接受的盐。还提供了含有该化合物的药物、药物组合物等。