4'-chloro-3-aminobenzophenone | 62261-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-chloro-3-aminobenzophenone
• 英文别名: 4-cloro-3'-amminobenzofenone；4-ClC6H4C(O)C6H4NH2；3-amino-4'-chlorobenzophenone；3-amino-4'-chloro-benzophenone；3-Amino-4'-chlor-benzophenon；(3-Aminophenyl)(4-chlorophenyl)methanone；(3-aminophenyl)-(4-chlorophenyl)methanone
• CAS: 62261-26-1
• 化学式: C₁₃H₁₀ClNO
• 分子量: 231.681
• InChiKey: FYWDQCUUITYDGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  4'-chloro-3-aminobenzophenone 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 11.0h， 生成 1-[(E)-C-(4-chlorophenyl)-N-hydroxycarbonimidoyl]-3-(dimethylsulfamoylamino)benzene
  参考文献：
  名称：

  Synthesis and antiviral activity of sulfonamidobenzophenone oximes and sulfonamidobenzamides

  摘要：

  To find antiviral agents, various sulfonamidobenzophenone oximes (II) were synthesized from the appropriate m-sulfonamidobenzophenones by hydroxylamine reaction. The reaction products were generally obtained as syn/anti mixtures which were separable by fractional crystallization. The anti isomer had more potent antipoliovirus activity than the syn isomer. Various sulfonamidobenzamides (III) which were structurally related to II were synthesized by the reactions of amino-substituted benzamides with sulfuryl chloride or amines with (aminosulfonyl)benzoyl chloride. Antiviral activity was examined by the plaque-inhibition test. Compounds 5, 36, and 69 exhibited strong antipicornavirus activity. The structure-activity relationships are discussed.

  DOI：

  10.1021/jm00153a018
• 作为产物：
  描述：

  4-氯-3-硝基苯甲酮 在 盐酸 、 乙醇 、 tin(ll) chloride 作用下， 生成 4'-chloro-3-aminobenzophenone
  参考文献：
  名称：

  2.新的潜在化学治疗剂。第三部分 二苯胺和αα-二苯甲胺的衍生物

  摘要：

  DOI：

  10.1039/jr9460000005

文献信息

• Aromatic ether-ketone polyamines, intermediates and products, and
  申请人：American Cyanamid

  公开号：US05026872A1

  公开（公告）日：1991-06-25

  Novel aromatic ether ketone diamine compounds and methods for their preparation are disclosed which comprise from about 3 to 8 aromatic rings interspersed with ether and ketone linkages. The novel ether ketone diamine compounds are useful as monomeric starting materials for the preparation of useful intermediates and useful thermoplastic and high temperature resistant polymers. In preferred embodiments, the novel ether ketone diamines are useful as curing agents for epoxy resin compositions and composite materials.

  揭示了一种新型的芳香醚酮二胺化合物及其制备方法，其中包含大约3到8个芳香环，夹杂着醚和酮键。这种新型醚酮二胺化合物可用作制备有用中间体和有用的热塑性和耐高温聚合物的单体起始材料。在优选实施例中，这种新型醚酮二胺可用作环氧树脂组合物和复合材料的固化剂。
• 1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions
  申请人：Rhone-Poulenc Sante

  公开号：US04783472A1

  公开（公告）日：1988-11-08

  A compound of the general formula I; ##STR1## in which R is hydrogen or a halogen or an alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridylcarbamoyl, dipyridylcarbamoyl, benzyl, alkylcarbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, benzoyloxy, alkylcarbonylamino, benzamido, phenyl, phenoxy or phenylthio group, X is oxygen or sulphur or an imino, alkylimino, phenylimino, benzylimino, sulphinyl, sulphonyl, carbonyl, carbonylmethylene, methylenecarbonyl, carbonylvinylene or vinylenecarbonyl group, or X represents a valency bond or a straight-chain alkylene group containing 1 to 4 carbon atoms and Ar is a phenyl, naphthyl, pyridyl, quinolinyl, isoquinolinyl, thienyl, benzothienyl, thieno[3,2-b]thien-2-yl or thieno[2,3-b]thien-2-yl group, it being possible for the group Ar to be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridylcarbamoyl, dipyridylcarbamoyl, benzyl, alkylcarbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, benzoyloxy, alkylcarbonylamino or benzamido group; each alkyl moiety containing 1 to 4 straight- or branched-chain carbon atoms; the compound being in separate enantiomeric form or mixtures thereof or a pharmaceutically acceptable salt thereof is useful in the treatment of all the pathological conditions in which PAF-acether may be directly or indirectly implicated.

  通式为I的化合物；##STR1## 其中R是氢或卤素或烷基，烷氧基，烷硫基，三氟甲基，氨基，烷基氨基，二烷基氨基，羟基，氰基，羧基，烷基磺酰基，烷基磺酰基，磺酰胺基，烷基磺酰胺基，二烷基磺酰胺基，氨基甲酰基，烷基氨甲酰基，二烷基氨甲酰基，苯基氨甲酰基，二苯基氨甲酰基，吡啶基氨甲酰基，二吡啶基氨甲酰基，苄基，烷基羰基，苯甲酰基，烷氧羰酰基，苯氧羰酰基，烷基羰酰氧基，苯甲酰氧基，烷基羰基氨基，苯甲酰胺基，苯基，苯氧基或苯硫基，X是氧或硫或亚胺基，烷基亚胺基，苯基亚胺基，苄基亚胺基，磺酰基，磺酰基，羰基，羰基亚甲基，羰基乙烯基或乙烯基羰基基团，或X表示价键或含有1到4个碳原子的直链烷基基团，Ar是苯基，萘基，吡啶基，喹啉基，异喹啉基，噻吩基，苯并噻吩基，噻吩[3,2-b]噻吩-2-基或噻吩[2,3-b]噻吩-2-基团，其中Ar基团可能是未取代或取代一个或多个卤素或烷基，烷氧基，烷硫基，三氟甲基，氨基，烷基氨基，二烷基氨基，羟基，氰基，羧基，烷基磺酰基，烷基磺酰基，磺酰胺基，烷基磺酰胺基，二烷基磺酰胺基，氨基甲酰基，烷基氨甲酰基，二烷基氨甲酰基，苯基氨甲酰基，二苯基氨甲酰基，吡啶基氨甲酰基，二吡啶基氨甲酰基，苄基，烷基羰基，苯甲酰基，烷氧羰酰基，苯氧羰酰基，烷基羰酰氧基，苯甲酰氧基，烷基羰基氨基，苯甲酰胺基或苯基氨基基团；每个烷基含有1到4个直链或支链碳原子；该化合物以分离的对映异构体形式或其混合物或其药学上可接受的盐形式在PAF-acether可能直接或间接涉及的所有病理情况的治疗中有用。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.2, 1.3.1, page 76 - 99
  作者：

  DOI：——

  日期：——
• FR1579473
  申请人：——

  公开号：——

  公开（公告）日：——
• Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template
  作者：Jane Wang、David Limburg、Jeff Carter、Gabriel Mbalaviele、James Gierse、Michael Vazquez

  DOI：10.1016/j.bmcl.2010.01.060

  日期：2010.3

  Here we describe the SAR of a series of potent and selective mPGES-1 inhibitors based on an oxicam template. Compound 13j demonstrated low nanomolar mPGES-1 inhibition in an enzyme assay. In addition, it displayed PGE(2) inhibition in a cell-based assay (0.42 mu M) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF(1 alpha). (C) 2010 Elsevier Ltd. All rights reserved.