7-(methoxymethoxy)-N,N-dimethylnaphthalen-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-(methoxymethoxy)-N,N-dimethylnaphthalen-2-amine
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: ZLLAGPTYNGURMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-(methoxymethoxy)-N,N-dimethylnaphthalen-2-amine 在 叔丁基锂 、 五氯化铌 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 3.0h， 生成 6-(dimethylamino)-3-hydroxy-2-naphthaldehyde
  参考文献：
  名称：

  苯并[g]香豆素-苯并噻唑杂化物：用于检测β淀粉样蛋白聚集体的荧光探针

  摘要：

  在这里，我们公开了一种新的开启型荧光探针（命名为BCB-1），用于检测 Aβ 斑块，它是阿尔茨海默病 (AD) 的重要生物标志物。BCB-1具有苯并[ g ]香豆素和苯并噻唑的混合结构，在感应 Aβ 斑块时在近红外 (NIR) 区域显示出显着的发射增强。BCB-1还显示出对 Aβ 斑块的高选择性和敏感性，并且在 AD 小鼠 (5XFAD) 大脑中证实了其生物成像适用性。我们期待我们卓越的 AD 诊断荧光探针广泛应用于 Aβ 斑块相关的临床和生物学研究。

  DOI：

  10.1002/bkcs.12525
• 作为产物：
  描述：

  2,7-二羟基萘 在 sodium metabisulfite 、 sodium hydride 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 10.0h， 生成 7-(methoxymethoxy)-N,N-dimethylnaphthalen-2-amine
  参考文献：
  名称：

  苯并[g]香豆素-苯并噻唑杂化物：用于检测β淀粉样蛋白聚集体的荧光探针

  摘要：

  在这里，我们公开了一种新的开启型荧光探针（命名为BCB-1），用于检测 Aβ 斑块，它是阿尔茨海默病 (AD) 的重要生物标志物。BCB-1具有苯并[ g ]香豆素和苯并噻唑的混合结构，在感应 Aβ 斑块时在近红外 (NIR) 区域显示出显着的发射增强。BCB-1还显示出对 Aβ 斑块的高选择性和敏感性，并且在 AD 小鼠 (5XFAD) 大脑中证实了其生物成像适用性。我们期待我们卓越的 AD 诊断荧光探针广泛应用于 Aβ 斑块相关的临床和生物学研究。

  DOI：

  10.1002/bkcs.12525

文献信息

• NOVEL TWO-PHOTON ABSORBING FLUORESCENT SUBSTANCE, AND SUBSTRATE SENSING METHOD USING SAME
  申请人：POSTECH ACADEMY - INDUSTRY FOUNDATION

  公开号：US20140377791A1

  公开（公告）日：2014-12-25

  The present invention relates to a compound which is a novel two-photon absorbing fluorescent substance, a production method for the compound, a fluorescence sensor and molecular probe able to sense various substrates or enzyme activity or the like using the same, and a method of sensing enzyme activity or the like using the same. More specifically, the present invention relates to a novel two-photon absorbing fluorescent substance which has the high photo-stability and large two-photon absorption cross-section value of acedan which is a two-photon absorbing fluorescent substance, and has the high fluorescence efficiency of coumarin which is a one-photon absorbing fluorescent substance, while exhibiting absorption and emission characteristics at a longer wavelength than existing acedan and coumarin and so being advantageous in in-vivo imaging. The compound according to the present invention can be used as a fluorescence sensor which is highly sensitive and selective for various substrates, and more particularly, can be used in the study and treatment of diseases in which MAO enzymes are involved such as mood disorders using MAO enzyme activity and inhibitor screening.

  本发明涉及一种新型的双光子吸收荧光物质，以及该化合物的生产方法、利用该化合物能够感知各种底物或酶活性的荧光传感器和分子探针，以及利用该化合物进行酶活性感知等的方法。更具体地，本发明涉及一种新型的双光子吸收荧光物质，具有高光稳定性和大的双光子吸收截面值，类似于双光子吸收荧光物质acedan，同时具有类似于单光子吸收荧光物质coumarin的高荧光效率，且在吸收和发射特性上比现有的acedan和coumarin具有更长的波长，因此在体内成像方面具有优势。根据本发明的化合物可用作高灵敏度和选择性的各种底物的荧光传感器，特别是可用于研究和治疗MAO酶参与的情绪障碍等疾病，利用MAO酶活性和抑制剂筛选。
• Two-photon absorbing compound with methods of synthesis and use
  申请人：Ahn Kyo Han

  公开号：US09353399B2

  公开（公告）日：2016-05-31

  Disclosed is a compound which is a two-photon absorbing fluorescent substance, a production method for the compound, a fluorescence sensor and molecular probe able to sense various substrates or enzyme activity or the like using the same, and a method of sensing enzyme activity or the like using the same. The disclosed compound can be used as a fluorescence sensor, and can be used in the study and treatment of diseases in which MAO enzymes are involved such as mood disorders using MAO enzyme activity and inhibitor screening.

  公开了一种两光子吸收荧光物质，该物质的生产方法，一种能够感知各种底物或酶活性等的荧光传感器和分子探针，以及使用该物质感知酶活性等的方法。公开的化合物可用作荧光传感器，并可用于研究和治疗涉及MAO酶的疾病，如利用MAO酶活性和抑制剂筛选来处理情绪障碍。
• FLUORESCENT PROBE SENSING TYROSINE KINASE AND USE THEREOF
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20160116455A1

  公开（公告）日：2016-04-28

  A fluorescent probe for detecting a tyrosine kinase using a compound having an ortho-hydroxy-benzaldehyde structure, and use thereof are provided. The fluorescent probe can show a change in fluorescence when the compound binds with a tyrosine kinase. The compound can be readily synthesized and has high stability and low cytotoxicity in vivo. The fluorescent probe can be used to image cells or tissues overexpressing the tyrosine kinase, the fluorescent probe can be effectively used in a composition for imaging the tissues and a method of imaging the tissues. Also, the fluorescent probe can be used to image cancer cells or tissues since the fluorescent probe can exhibit fluorescence when the fluorescent probe binds to the cancer cells or tissues overexpressing the tyrosine kinase.

  提供一种用具有邻羟基苯甲醛结构的化合物检测酪氨酸激酶的荧光探针，以及其使用方法。当该化合物与酪氨酸激酶结合时，荧光探针可以显示出荧光变化。该化合物可以容易合成，在体内具有高稳定性和低细胞毒性。荧光探针可用于成像过表达酪氨酸激酶的细胞或组织，可有效用于成像组织的组合物和成像组织的方法。此外，荧光探针可用于成像癌细胞或组织，因为当荧光探针与过表达酪氨酸激酶的癌细胞或组织结合时，荧光探针可以显示出荧光。
• 하이드라진 검출용 조성물 및 이를 이용한 하이드라진 검출방법
  申请人：경희대학교 산학협력단

  公开号：KR20220005871A

  公开（公告）日：2022-01-14

  본 발명은 하이드라진 검출용 조성물 및 하이드라진 검출 방법에 관한 것으로서, 더욱 자세하게는 화학식 1로 표시되는 화합물을 포함하는 하이드라진 검출용 조성물 및 상기 조성물을 이용한 하이드라진 검출 방법을 제공하는 것이다.

  本发明涉及一种用于检测羟基苯甲酸酯的组合物及其检测方法，更具体地提供了一种含有化学式1所示化合物的羟基苯甲酸酯检测组合物及利用该组合物进行羟基苯甲酸酯检测的方法。
• High Stability of a Donor–Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging
  作者：Heejo Moon、Yuna Jung、Youngseo Kim、Byeong Wook Kim、Jin Gyu Choi、Na Hee Kim、Myung Sook Oh、Sungnam Park、B. Moon Kim、Dokyoung Kim

  DOI：10.1021/acs.orglett.9b00784

  日期：2019.6.7

  A new donor (D)-acceptor (A) type naphthalene-based oxazepine-containing fluorophore, OXN-1, is reported, which shows unusually high stability in various environments. Its photophysical properties and structural stabilities under harsh conditions are thoroughly examined. The high stability of OXN-1 is explained by quantum chemical calculations. Its exceptional bioimaging capabilities for cells with low cytotoxicity are verified. In addition, its deep tissue imaging ability with two-photon microscopy (TPM) is evaluated.