2-ethoxy-1-phenylprop-2-en-1-one | 85616-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethoxy-1-phenylprop-2-en-1-one
• 英文别名: Ethoxy phenyl prop-2-en-1-one
• CAS: 85616-23-5
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: JDTGHJPMPFQQRL-UHFFFAOYSA-N

物化性质

• 沸点：
  156-158 °C(Press: 28 Torr)
• 密度：
  1.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethoxy-1-phenylprop-2-en-1-one 在 二甲基硫 、 氧气 、 臭氧 作用下， 生成 苯甲酰甲酸乙酯
  参考文献：
  名称：

  Palladium-catalyzed coupling reactions of (.alpha.-ethoxyvinyl)trimethylstannane with vinyl and aryl triflates

  摘要：

  DOI：

  10.1021/jo00297a029
• 作为产物：
  描述：

  N,N-二甲基苯甲酰胺 以90%的产率得到
  参考文献：
  名称：

  Shimano Masanao, Meyers A. I., Tetrahedron Lett, 35 (1994) N 42, S 7727-7730

  摘要：

  DOI：

文献信息

• Enolate free α-alkoxyvinyllithium reagents: Improved preparation and reaction with N,N-dialkylcarboxamides
  作者：Masanao Shimano、A.I. Meyers

  DOI：10.1016/0040-4039(94)80103-7

  日期：1994.10

  The titled lithium reagents add to a variety of N,N-dialkylcarboxamides furnishing the enol ethers of α-dicarbonyl compounds.

  标题为锂的试剂添加到各种N，N-二烷基羧酰胺中，提供了α-二羰基化合物的烯醇醚。
• An Efficient Synthesis of α-Branched Enones
  作者：Stephen F. Martin、David A. Kummer、Jehrod B. Brenneman

  DOI：10.1055/s-2004-829095

  日期：——

  A new method for preparing α-branched enones from carboxylic acid derivatives is reported. The procedure commenced by the reaction of N,O-dimethylamides with a masked acyl anion equivalent, followed by the addition of (trimethylsilyl-methyl)cerium dichloride to give intermediates that undergo Lewis acid mediated olefination to produce enol ethers that are then hydrolyzed to afford simple α-branched

  报道了一种由羧酸衍生物制备α-支化烯酮的新方法。该过程开始于 N,O-二甲基酰胺与掩蔽的酰基阴离子等价物的反应，然后添加（三甲基甲硅烷基-甲基）二氯化铈得到中间体，该中间体经过路易斯酸介导的烯化生成烯醇醚，然后水解得到简单的α-支链烯酮，总产率高。
• Selective Synthesis of α‐Alkoxy Enones by α‐Addition of Alcohols to Alkynones Using 1,1,1,3,3,3‐Hexafluoroisopropanol and PPh ₃ as Co‐catalysts
  作者：Xiu‐Ming Li、Jing‐Kui Yang

  DOI：10.1002/ejoc.202201163

  日期：2022.12.19

  The α-addition of alcohols to alkynones was demonstrated. A series of α-alkoxy enones can directly be synthesized in moderate to high yields under mild conditions. Mechanism studies were carried out by various means.

  证明了醇与炔酮的 α-加成。一系列α-烷氧基烯酮可以在温和条件下以中等到高产率直接合成。通过各种方式进行了机理研究。
• Imidazole-based heterocyclic compounds
  申请人：Procomcure Biotech GmbH

  公开号：US10314820B2

  公开（公告）日：2019-06-11

  The present invention relates to novel compounds of formula (I) suitable e.g. as therapeutic agents for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. The present invention also relates to processes for making said agents.

  本发明涉及适用于治疗哺乳动物疾病的新型式（I）化合物，特别是适用于治疗哺乳动物微生物感染的新型治疗剂。本发明还涉及包含上述制剂的药物组合物在治疗哺乳动物疾病中的用途，特别是在治疗微生物感染中的用途。本发明的制剂和药物组合物在治疗与抗生素耐药微生物相关的疾病方面具有特别重要的意义。本发明还涉及上述制剂的制造工艺。
• Imidazole-based antimicrobial agents
  申请人：Procomcure Biotech GmbH

  公开号：US10456379B2

  公开（公告）日：2019-10-29

  The present invention relates to novel therapeutic agents suitable for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes.

  本发明涉及适用于治疗哺乳动物疾病的新型治疗剂，特别是适用于治疗哺乳动物微生物感染的新型治疗剂。本发明还涉及包含上述制剂的药物组合物在治疗哺乳动物疾病，特别是治疗微生物感染中的用途。本发明的制剂和药物组合物在治疗与抗生素耐药微生物相关的疾病方面具有特别重要的意义。