4(trichloroethenyl) o-nitroaniline | 63630-18-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4(trichloroethenyl) o-nitroaniline
• 英文别名: 2-Nitro-4-(trichlorethenyl)anilin；2-Nitro-4-(trichloroethenyl)aniline；2-nitro-4-(1,2,2-trichloroethenyl)aniline
• CAS: 63630-18-2
• 化学式: C₈H₅Cl₃N₂O₂
• 分子量: 267.499
• InChiKey: KVMJXBITHVSDBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4(trichloroethenyl) o-nitroaniline 在 盐酸 、 铁粉 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 克洛索隆
  参考文献：
  名称：

  4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

  摘要：

  The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

  DOI：

  10.1021/jm00219a025
• 作为产物：
  描述：

  4-(Trichlorethenyl)anilin 生成 4(trichloroethenyl) o-nitroaniline
  参考文献：
  名称：

  4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

  摘要：

  The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

  DOI：

  10.1021/jm00219a025

文献信息

• Anthelmintic benzimidazoles
  申请人：Merck & Co., Inc.

  公开号：US04174400A1

  公开（公告）日：1979-11-13

  Benzimidazole compounds are disclosed which are substituted at the 2-position with a loweralkoxy carbonylamino group and at the 5-position with a halogenated loweralkenyl group or a halogenated loweralkoxy, loweralkylthio, loweralkylsulfinyl or loweralkylsulfonyl. Processes for the preparation of such compounds are disclosed. The compounds are active anthelmintic agents and compositions for such use are also disclosed.

  本文介绍了苯并咪唑化合物，其在2位上被低碳酰氨基烷氧基取代，在5位上被卤代低烯基基团或卤代低烷氧基、低烷基硫基、低烷基亚砜基或低烷基磺酰基取代。本文还介绍了制备这种化合物的方法。这些化合物是活性驱虫剂，还介绍了这种用途的组合物。
• MROZIK H.; BOCHIS R. J.; ESKOLA P., J. MED. CHEM., 1977, 20,
  作者：MROZIK H.、 BOCHIS R. J.、 ESKOLA P.

  DOI：——

  日期：——
• 2-Alkoxycarbonylamino benzimidazoles having a halogen-containing substituent, their preparation and their use as parasiticides
  申请人：Merck & Co., Inc.

  公开号：EP0009361B1

  公开（公告）日：1984-05-23
• US4174400A
  申请人：——

  公开号：US4174400A

  公开（公告）日：1979-11-13
• 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide
  作者：Helmut Mrozik、Richard J. Bochis、Philip Eskola、Alexander Matzuk、Frank S. Waksmunski、Leonard E. Olen、George Schwartzkopf、Alex Grodski、Bruce O. Linn

  DOI：10.1021/jm00219a025

  日期：1977.9

  The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.