1-[(4-氯苯基)-哌啶-1-基甲基]哌啶 | 55591-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[(4-氯苯基)-哌啶-1-基甲基]哌啶
• 英文名称: 1,1'-((4-chlorophenyl)methylene)dipiperidine
• 英文别名: 1,1'-(p-chlorobenzylidene)dipiperidine；choloro-1 dipiperidinomethyl-4 benzene；1,1'-(4-chloro-phenylmethanediyl)-bis-piperidine；Methane, (4-chlorophenyl)bis(1-piperidyl)-；1-[(4-chlorophenyl)-piperidin-1-ylmethyl]piperidine
• CAS: 55591-37-2
• 化学式: C₁₇H₂₅ClN₂
• 分子量: 292.852
• InChiKey: LQNVSTLCVWZTTL-UHFFFAOYSA-N

物化性质

• 沸点：
  370.2±32.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[(4-氯苯基)-哌啶-1-基甲基]哌啶 在 甲酸 作用下， 以 various solvent(s) 为溶剂， 生成 哌啶 、 1-[(4-氯苯基)甲基]哌啶
  参考文献：
  名称：

  Fukawa, Hidemichi; Suzuki, Kunio; Sekiya, Minoru, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 10, p. 2868 - 2873

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 4-氯苯甲醛 以 苯 为溶剂， 反应 16.0h， 以97%的产率得到1-[(4-氯苯基)-哌啶-1-基甲基]哌啶
  参考文献：
  名称：

  Copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals under atmosphere leading to α-aryl glycine derivatives and diarylmethylamine derivatives

  摘要：

  We demonstrated a copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals leading to the synthesis of alpha-aryl glycines and diarylmethylamines. Under an ambient atmosphere, this catalytic system could be applied to the activation of a C(sp(3))-O bond of N,O-acetals with an ester and an aryl group, or without a coordinating substituent, as well as to a C(sp(3))-N bond of N,N-aminals. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.05.068

文献信息

• Zinc-Mediated Allylation and Alkylation of Aminals in the Presence of TMSCl and Diisopropylamine
  作者：Bunpei Hatano、Keita Nagahashi、Tatsuro Kijima

  DOI：10.1021/jo8019797

  日期：2008.11.21

  An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, alpha-bromoacetate, and alpha-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.
• Aube, Philippe; Christot, Isabelle; Combret, Jean-Claude, Bulletin de la Societe Chimique de France, 1988, # 6, p. 1009 - 1014
  作者：Aube, Philippe、Christot, Isabelle、Combret, Jean-Claude、Klein, Jean-Louis

  DOI：——

  日期：——
• Allylation of N,N-Acetal Derivatives Using Allyl Tin Regent in the Presence of Aluminum Chloride
  作者：Bunpei Hatano、Xiaonan Sun、Takanori Obu、Tatsuro Kijima、Satoshi Murakami、Shigeru Matsuba

  DOI：10.3987/com-13-12845

  日期：——

  Allylation of N,N-acetal derivatives proceeded efficiently using allyl tin regent in the presence of aluminum chloride, giving homoallylamines in good yields. This allylation was applied for N,S-acetals to give the corresponding homoallylamines.
• Copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals under atmosphere leading to α-aryl glycine derivatives and diarylmethylamine derivatives
  作者：Norio Sakai、Hiroaki Hori、Yoshihiro Yoshida、Takeo Konakahara、Yohei Ogiwara

  DOI：10.1016/j.tet.2015.05.068

  日期：2015.7

  We demonstrated a copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals leading to the synthesis of alpha-aryl glycines and diarylmethylamines. Under an ambient atmosphere, this catalytic system could be applied to the activation of a C(sp(3))-O bond of N,O-acetals with an ester and an aryl group, or without a coordinating substituent, as well as to a C(sp(3))-N bond of N,N-aminals. (C) 2015 Elsevier Ltd. All rights reserved.
• Fukawa, Hidemichi; Suzuki, Kunio; Sekiya, Minoru, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 10, p. 2868 - 2873
  作者：Fukawa, Hidemichi、Suzuki, Kunio、Sekiya, Minoru

  DOI：——

  日期：——