2-Amino-4-(trichlorethenyl)benzolsulfonamid | 63630-20-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-4-(trichlorethenyl)benzolsulfonamid
• 英文别名: 2-Amino-4-(1,2,2-trichloroethenyl)benzenesulfonamide
• CAS: 63630-20-6
• 化学式: C₈H₇Cl₃N₂O₂S
• 分子量: 301.581
• InChiKey: WKKMJSGKLXEPGD-UHFFFAOYSA-N

物化性质

• 熔点：
  128-129 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• 沸点：
  483.0±55.0 °C(Predicted)
• 密度：
  1.653±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Amino-4-(trichlorethenyl)benzolsulfonamid 生成 克洛索隆
  参考文献：
  名称：

  4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

  摘要：

  The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

  DOI：

  10.1021/jm00219a025
• 作为产物：
  描述：

  2-Nitro-4-(trichlorethenyl)benzoesulfonsaeureamid 在 盐酸 、 铁粉 作用下， 以 乙醇 为溶剂， 生成 2-Amino-4-(trichlorethenyl)benzolsulfonamid
  参考文献：
  名称：

  4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

  摘要：

  The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

  DOI：

  10.1021/jm00219a025

文献信息

• GATTO, GREGORY J.;MERTEL, HOLLY E., J. LABELL. COMPOUNDS AND RADIOPHARM., 28,(1990) N, C. 943-953
  作者：GATTO, GREGORY J.、MERTEL, HOLLY E.

  DOI：——

  日期：——
• MROZIK H.; BOCHIS R. J.; ESKOLA P., J. MED. CHEM., 1977, 20,
  作者：MROZIK H.、 BOCHIS R. J.、 ESKOLA P.

  DOI：——

  日期：——
• 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide
  作者：Helmut Mrozik、Richard J. Bochis、Philip Eskola、Alexander Matzuk、Frank S. Waksmunski、Leonard E. Olen、George Schwartzkopf、Alex Grodski、Bruce O. Linn

  DOI：10.1021/jm00219a025

  日期：1977.9

  The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.